Changes in higher order aberrations during use of orthokeratology lenses

Trine Møldrup Jakobsen, Anders Peter Søndergaard, Flemming Møller

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review


During overnight ortho-k lens usage corneal shape is altered. We aim to evaluate changes in total corneal higher order aberrations (HOA) during treatment with orthokeratology lenses.

An 18-month 1:1 randomized, controlled trial on 60 myopic children aged 6 to 12 years with the intervention being orthokeratology lenses (OKL) and the control-group receiving single-vision spectacles. Total corneal root mean square (RMS) HOA were measured with scheimpflug topography (Pentacam, Oculus, Wetzlar, Germany) at baseline, day 3, day 7, 1-, 3-, 6-, 9-, 12-, 15-, and 18-month follow-up for the intervention group. Data from right and left eyes were included in the analysis. Four consecutive measures per eye were obtained at baseline, 6-, 12-, and 18-month follow-up. For the remaining follow-up visits, two or three measurements were obtained. Only measurements with the status OK and Error 0 were included in the analysis. The measurements for each eye were averaged for examination. Statistically data were handled with a mixed model using Stata software (version 16.1; StataCorp, College Station, TX, USA). For subjects dropping out of the study, data were included in the analysis until dropout occurred. A p-value < 0.05 was considered statistically significant.

A total of thirty patients were included in the analysis. We found a significant increase in RMS HOA from 0.35 μm at baseline to 0.97 μm at day 3 (P < 0.001, 95% confidence interval (95% CI) 0.53 to 0.72, mixed model) and a significant decrease from day 3 to day 7 of 0.13 μm (P < 0.02, 95% CI –0.24 to –0.03). Hereafter there were no significant changes in RMS HOA (P ≥ 0.26).

OKL use increases HOA in children. The changes are stable seven days after treatment initiation.
StatusUdgivet - 2022
BegivenhedInternational Myopia Conference -
Varighed: 4. sep. 20227. sep. 2022


KonferenceInternational Myopia Conference