Changes in HbA1c and circulating and adipose tissue androgen levels in overweight-obese women with polycystic ovary syndrome in response to electroacupuncture

E. Stener-Victorin, M. Maliqueo, M Soligo, V Protto, L Manni, E Jerlhag, M. Kokosar, A. Sazonova, C J Behre, M. Lind, Claes Ohlsson, K Højlund, A. Benrick

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Resumé

AIM: Insulin sensitivity is ~40% lower in women with polycystic ovary syndrome (PCOS) than in controls. We tested the hypothesis that 5 weeks of electroacupuncture treatment improves glucose regulation and androgen levels in overweight/obese women with PCOS.

MATERIAL AND METHODS: Seventeen women with PCOS, aged 18 to 38 years, with a body mass index (BMI) ≥25 kg/m(2) and diagnosed with PCOS were included in this experimental and feasibility study and subjected to five weeks of electroacupuncture treatments three times/week. The primary outcome was changes in whole-body glucose homeostasis measured by euglycemic hyperinsulinemic clamp before and after the intervention. Secondary outcome were changes in HbA1c, circulating catecholamines, adipocyte size and adipose tissue expression of sex steroids and nerve growth factor (NGF).

RESULTS: No significant change in glucose homeostasis was observed, but HbA1c decreased by 9.5% (p = 0.004), circulating testosterone decreased by 22% (p = 0.0007) and dihydrotestosterone decreased by 12% (p = 0.007). The two vagal activity markers of plasma serotonin levels and the dopamine metabolite homovanillic acid decreased by 21% (p = 0.027) and 20% (p = 0.011), respectively. Adipose tissue concentrations of testosterone decreased by 18% (p = 0.049), and androstenedione decreased by 13% (p = 0.035), and mature NGF/proNGF ratio, a marker of sympathetic activity, increased (p = 0.04). These changes occurred without changes in anthropometrics.

CONCLUSION: Five weeks of electroacupuncture treatment improves HbA1c and circulating and adipose tissue androgens in women with PCOS. This effect is mediated, at least in part, via modulation of vagal activity and adipose tissue sympathetic activity. Based on these findings, we have recently initiated a randomized controlled study (NTC02647827).

OriginalsprogEngelsk
TidsskriftObesity Science & Practice
Vol/bind2
Udgave nummer4
Sider (fra-til)426-435
ISSN2055-2238
DOI
StatusUdgivet - 2016

Fingeraftryk

Electroacupuncture
Polycystic Ovary Syndrome
Adipose Tissue
Nerve Growth Factor
Homeostasis
Homovanillic Acid
Glucose Clamp Technique
Feasibility Studies
Adipocytes
Insulin Resistance
Body Mass Index

Citer dette

Stener-Victorin, E. ; Maliqueo, M. ; Soligo, M ; Protto, V ; Manni, L ; Jerlhag, E ; Kokosar, M. ; Sazonova, A. ; Behre, C J ; Lind, M. ; Ohlsson, Claes ; Højlund, K ; Benrick, A. / Changes in HbA1c and circulating and adipose tissue androgen levels in overweight-obese women with polycystic ovary syndrome in response to electroacupuncture. I: Obesity Science & Practice. 2016 ; Bind 2, Nr. 4. s. 426-435.
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title = "Changes in HbA1c and circulating and adipose tissue androgen levels in overweight-obese women with polycystic ovary syndrome in response to electroacupuncture",
abstract = "AIM: Insulin sensitivity is ~40{\%} lower in women with polycystic ovary syndrome (PCOS) than in controls. We tested the hypothesis that 5 weeks of electroacupuncture treatment improves glucose regulation and androgen levels in overweight/obese women with PCOS.MATERIAL AND METHODS: Seventeen women with PCOS, aged 18 to 38 years, with a body mass index (BMI) ≥25 kg/m(2) and diagnosed with PCOS were included in this experimental and feasibility study and subjected to five weeks of electroacupuncture treatments three times/week. The primary outcome was changes in whole-body glucose homeostasis measured by euglycemic hyperinsulinemic clamp before and after the intervention. Secondary outcome were changes in HbA1c, circulating catecholamines, adipocyte size and adipose tissue expression of sex steroids and nerve growth factor (NGF).RESULTS: No significant change in glucose homeostasis was observed, but HbA1c decreased by 9.5{\%} (p = 0.004), circulating testosterone decreased by 22{\%} (p = 0.0007) and dihydrotestosterone decreased by 12{\%} (p = 0.007). The two vagal activity markers of plasma serotonin levels and the dopamine metabolite homovanillic acid decreased by 21{\%} (p = 0.027) and 20{\%} (p = 0.011), respectively. Adipose tissue concentrations of testosterone decreased by 18{\%} (p = 0.049), and androstenedione decreased by 13{\%} (p = 0.035), and mature NGF/proNGF ratio, a marker of sympathetic activity, increased (p = 0.04). These changes occurred without changes in anthropometrics.CONCLUSION: Five weeks of electroacupuncture treatment improves HbA1c and circulating and adipose tissue androgens in women with PCOS. This effect is mediated, at least in part, via modulation of vagal activity and adipose tissue sympathetic activity. Based on these findings, we have recently initiated a randomized controlled study (NTC02647827).",
author = "E. Stener-Victorin and M. Maliqueo and M Soligo and V Protto and L Manni and E Jerlhag and M. Kokosar and A. Sazonova and Behre, {C J} and M. Lind and Claes Ohlsson and K H{\o}jlund and A. Benrick",
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doi = "10.1002/osp4.78",
language = "English",
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journal = "Obesity Science & Practice",
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Stener-Victorin, E, Maliqueo, M, Soligo, M, Protto, V, Manni, L, Jerlhag, E, Kokosar, M, Sazonova, A, Behre, CJ, Lind, M, Ohlsson, C, Højlund, K & Benrick, A 2016, 'Changes in HbA1c and circulating and adipose tissue androgen levels in overweight-obese women with polycystic ovary syndrome in response to electroacupuncture', Obesity Science & Practice, bind 2, nr. 4, s. 426-435. https://doi.org/10.1002/osp4.78

Changes in HbA1c and circulating and adipose tissue androgen levels in overweight-obese women with polycystic ovary syndrome in response to electroacupuncture. / Stener-Victorin, E.; Maliqueo, M.; Soligo, M; Protto, V; Manni, L; Jerlhag, E; Kokosar, M.; Sazonova, A.; Behre, C J; Lind, M.; Ohlsson, Claes; Højlund, K; Benrick, A.

I: Obesity Science & Practice, Bind 2, Nr. 4, 2016, s. 426-435.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Changes in HbA1c and circulating and adipose tissue androgen levels in overweight-obese women with polycystic ovary syndrome in response to electroacupuncture

AU - Stener-Victorin, E.

AU - Maliqueo, M.

AU - Soligo, M

AU - Protto, V

AU - Manni, L

AU - Jerlhag, E

AU - Kokosar, M.

AU - Sazonova, A.

AU - Behre, C J

AU - Lind, M.

AU - Ohlsson, Claes

AU - Højlund, K

AU - Benrick, A.

PY - 2016

Y1 - 2016

N2 - AIM: Insulin sensitivity is ~40% lower in women with polycystic ovary syndrome (PCOS) than in controls. We tested the hypothesis that 5 weeks of electroacupuncture treatment improves glucose regulation and androgen levels in overweight/obese women with PCOS.MATERIAL AND METHODS: Seventeen women with PCOS, aged 18 to 38 years, with a body mass index (BMI) ≥25 kg/m(2) and diagnosed with PCOS were included in this experimental and feasibility study and subjected to five weeks of electroacupuncture treatments three times/week. The primary outcome was changes in whole-body glucose homeostasis measured by euglycemic hyperinsulinemic clamp before and after the intervention. Secondary outcome were changes in HbA1c, circulating catecholamines, adipocyte size and adipose tissue expression of sex steroids and nerve growth factor (NGF).RESULTS: No significant change in glucose homeostasis was observed, but HbA1c decreased by 9.5% (p = 0.004), circulating testosterone decreased by 22% (p = 0.0007) and dihydrotestosterone decreased by 12% (p = 0.007). The two vagal activity markers of plasma serotonin levels and the dopamine metabolite homovanillic acid decreased by 21% (p = 0.027) and 20% (p = 0.011), respectively. Adipose tissue concentrations of testosterone decreased by 18% (p = 0.049), and androstenedione decreased by 13% (p = 0.035), and mature NGF/proNGF ratio, a marker of sympathetic activity, increased (p = 0.04). These changes occurred without changes in anthropometrics.CONCLUSION: Five weeks of electroacupuncture treatment improves HbA1c and circulating and adipose tissue androgens in women with PCOS. This effect is mediated, at least in part, via modulation of vagal activity and adipose tissue sympathetic activity. Based on these findings, we have recently initiated a randomized controlled study (NTC02647827).

AB - AIM: Insulin sensitivity is ~40% lower in women with polycystic ovary syndrome (PCOS) than in controls. We tested the hypothesis that 5 weeks of electroacupuncture treatment improves glucose regulation and androgen levels in overweight/obese women with PCOS.MATERIAL AND METHODS: Seventeen women with PCOS, aged 18 to 38 years, with a body mass index (BMI) ≥25 kg/m(2) and diagnosed with PCOS were included in this experimental and feasibility study and subjected to five weeks of electroacupuncture treatments three times/week. The primary outcome was changes in whole-body glucose homeostasis measured by euglycemic hyperinsulinemic clamp before and after the intervention. Secondary outcome were changes in HbA1c, circulating catecholamines, adipocyte size and adipose tissue expression of sex steroids and nerve growth factor (NGF).RESULTS: No significant change in glucose homeostasis was observed, but HbA1c decreased by 9.5% (p = 0.004), circulating testosterone decreased by 22% (p = 0.0007) and dihydrotestosterone decreased by 12% (p = 0.007). The two vagal activity markers of plasma serotonin levels and the dopamine metabolite homovanillic acid decreased by 21% (p = 0.027) and 20% (p = 0.011), respectively. Adipose tissue concentrations of testosterone decreased by 18% (p = 0.049), and androstenedione decreased by 13% (p = 0.035), and mature NGF/proNGF ratio, a marker of sympathetic activity, increased (p = 0.04). These changes occurred without changes in anthropometrics.CONCLUSION: Five weeks of electroacupuncture treatment improves HbA1c and circulating and adipose tissue androgens in women with PCOS. This effect is mediated, at least in part, via modulation of vagal activity and adipose tissue sympathetic activity. Based on these findings, we have recently initiated a randomized controlled study (NTC02647827).

U2 - 10.1002/osp4.78

DO - 10.1002/osp4.78

M3 - Journal article

C2 - 28090348

VL - 2

SP - 426

EP - 435

JO - Obesity Science & Practice

JF - Obesity Science & Practice

SN - 2055-2238

IS - 4

ER -