Changes in fibroblast growth factor 23 during treatment of secondary hyperparathyroidism with alfacalcidol or paricalcitol

Ditte Hansen, Knud Rasmussen, Susanne M Pedersen, Lars M Rasmussen, Lisbet Brandi

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

BACKGROUND: Fibroblast growth factor 23 (FGF23) increases renal phosphate excretion and decreases the formation of 1,25 dihydroxyvitamin D. In patients with chronic kidney disease, plasma FGF23 levels are markedly elevated by unknown mechanisms. We explored the changes in FGF23 during treatment of secondary hyperparathyroidism (SHPT) with alfacalcidol or paricalcitol in haemodialysis patients.METHODS: Intravenous alfacalcidol and paricalcitol were compared in haemodialysis patients with SHPT in a randomized 2 × 16-week cross-over study, with 6 weeks washout period preceding treatment and between treatment periods. In 57 of the enrolled patients, blood samples were frozen before and after each treatment period and available for measurement of FGF23.RESULTS: Treatment with both analogues increased FGF23 (P <0.05 in all treatment periods). The magnitude of increase was similar for alfacalcidol and paricalcitol (Period 1: 223 versus 314%; P = 0.384 and Period 2: 174 versus 227%; P = 0.510) and the levels returned to pre-treatment levels during the washout period. Independent predictors of rise in FGF23 were baseline levels of FGF23 (P <0.01), changes in ionized calcium (P <0.01) and phosphate (P <0.01) and cumulative dose of vitamin D analogues (P = 0.024).CONCLUSION: Alfacalcidol and paricalcitol increase the plasma levels of FGF23 equally and substantially in haemodialysis patients.
OriginalsprogEngelsk
TidsskriftNephrology, Dialysis, Transplantation
Vol/bind27
Udgave nummer6
Sider (fra-til)2263-9
Antal sider7
ISSN0931-0509
DOI
StatusUdgivet - 2011

Fingeraftryk Dyk ned i forskningsemnerne om 'Changes in fibroblast growth factor 23 during treatment of secondary hyperparathyroidism with alfacalcidol or paricalcitol'. Sammen danner de et unikt fingeraftryk.

Citationsformater