Cesarean section and disease associated with immune function

Kim Kristensen, Lonny Henriksen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Earlier studies have shown that delivery by cesarean section (CS) is associated with an increased risk of disease associated with immune function in the offspring, but these studies have generally not discriminated between the effect of acute and elective CS.

OBJECTIVE: We sought to further explore these associations using discrimination between the effects of acute versus elective CS.

METHODS: We performed a population- and national register-based cohort study including all children born in Denmark from January 1997 through December 2012. Hazard ratios for diseases associated with immune function in children delivered by acute and elective CS with vaginal delivery as the reference were calculated by using Cox regression. All analyses were adjusted for gestational age, sex, birth weight, maternal age, maternal smoking during pregnancy, and complications during pregnancy (preeclampsia, eclampsia, hemorrhage, and hyperemesis).

RESULTS: A total of 750,569 children aged 0 to 14 years were included. Children delivered by both acute and elective CS had an increased risk of asthma, laryngitis, and gastroenteritis. Children delivered by acute CS had an increased risk of ulcerative colitis and celiac disease, whereas children delivered by elective CS had an increased risk of lower respiratory tract infection and juvenile idiopathic arthritis. The effect of elective CS was higher than the effect of acute CS on the risk of asthma.

CONCLUSION: Children delivered by CS are at increased risk of disease associated with immune function. The effect is mainly on diseases involving the mucosal immune system.

OriginalsprogEngelsk
TidsskriftJournal of Allergy and Clinical Immunology
Vol/bind137
Udgave nummer2
Sider (fra-til)587-90
Antal sider4
ISSN0091-6749
DOI
StatusUdgivet - feb. 2016

Fingeraftryk

Eclampsia
Pregnancy Complications
Maternal Age
Gastroenteritis
Celiac Disease
Denmark
Pre-Eclampsia
Ulcerative Colitis
Gestational Age
Registries
Immune System
Cohort Studies
Smoking
Mothers

Bibliografisk note

Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Citer dette

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abstract = "BACKGROUND: Earlier studies have shown that delivery by cesarean section (CS) is associated with an increased risk of disease associated with immune function in the offspring, but these studies have generally not discriminated between the effect of acute and elective CS.OBJECTIVE: We sought to further explore these associations using discrimination between the effects of acute versus elective CS.METHODS: We performed a population- and national register-based cohort study including all children born in Denmark from January 1997 through December 2012. Hazard ratios for diseases associated with immune function in children delivered by acute and elective CS with vaginal delivery as the reference were calculated by using Cox regression. All analyses were adjusted for gestational age, sex, birth weight, maternal age, maternal smoking during pregnancy, and complications during pregnancy (preeclampsia, eclampsia, hemorrhage, and hyperemesis).RESULTS: A total of 750,569 children aged 0 to 14 years were included. Children delivered by both acute and elective CS had an increased risk of asthma, laryngitis, and gastroenteritis. Children delivered by acute CS had an increased risk of ulcerative colitis and celiac disease, whereas children delivered by elective CS had an increased risk of lower respiratory tract infection and juvenile idiopathic arthritis. The effect of elective CS was higher than the effect of acute CS on the risk of asthma.CONCLUSION: Children delivered by CS are at increased risk of disease associated with immune function. The effect is mainly on diseases involving the mucosal immune system.",
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Cesarean section and disease associated with immune function. / Kristensen, Kim; Henriksen, Lonny.

I: Journal of Allergy and Clinical Immunology, Bind 137, Nr. 2, 02.2016, s. 587-90.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Cesarean section and disease associated with immune function

AU - Kristensen, Kim

AU - Henriksen, Lonny

N1 - Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

PY - 2016/2

Y1 - 2016/2

N2 - BACKGROUND: Earlier studies have shown that delivery by cesarean section (CS) is associated with an increased risk of disease associated with immune function in the offspring, but these studies have generally not discriminated between the effect of acute and elective CS.OBJECTIVE: We sought to further explore these associations using discrimination between the effects of acute versus elective CS.METHODS: We performed a population- and national register-based cohort study including all children born in Denmark from January 1997 through December 2012. Hazard ratios for diseases associated with immune function in children delivered by acute and elective CS with vaginal delivery as the reference were calculated by using Cox regression. All analyses were adjusted for gestational age, sex, birth weight, maternal age, maternal smoking during pregnancy, and complications during pregnancy (preeclampsia, eclampsia, hemorrhage, and hyperemesis).RESULTS: A total of 750,569 children aged 0 to 14 years were included. Children delivered by both acute and elective CS had an increased risk of asthma, laryngitis, and gastroenteritis. Children delivered by acute CS had an increased risk of ulcerative colitis and celiac disease, whereas children delivered by elective CS had an increased risk of lower respiratory tract infection and juvenile idiopathic arthritis. The effect of elective CS was higher than the effect of acute CS on the risk of asthma.CONCLUSION: Children delivered by CS are at increased risk of disease associated with immune function. The effect is mainly on diseases involving the mucosal immune system.

AB - BACKGROUND: Earlier studies have shown that delivery by cesarean section (CS) is associated with an increased risk of disease associated with immune function in the offspring, but these studies have generally not discriminated between the effect of acute and elective CS.OBJECTIVE: We sought to further explore these associations using discrimination between the effects of acute versus elective CS.METHODS: We performed a population- and national register-based cohort study including all children born in Denmark from January 1997 through December 2012. Hazard ratios for diseases associated with immune function in children delivered by acute and elective CS with vaginal delivery as the reference were calculated by using Cox regression. All analyses were adjusted for gestational age, sex, birth weight, maternal age, maternal smoking during pregnancy, and complications during pregnancy (preeclampsia, eclampsia, hemorrhage, and hyperemesis).RESULTS: A total of 750,569 children aged 0 to 14 years were included. Children delivered by both acute and elective CS had an increased risk of asthma, laryngitis, and gastroenteritis. Children delivered by acute CS had an increased risk of ulcerative colitis and celiac disease, whereas children delivered by elective CS had an increased risk of lower respiratory tract infection and juvenile idiopathic arthritis. The effect of elective CS was higher than the effect of acute CS on the risk of asthma.CONCLUSION: Children delivered by CS are at increased risk of disease associated with immune function. The effect is mainly on diseases involving the mucosal immune system.

KW - Adolescent

KW - Cesarean Section/adverse effects

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Delivery, Obstetric

KW - Denmark

KW - Disease Susceptibility/immunology

KW - Female

KW - Humans

KW - Immunity

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Pregnancy

KW - Proportional Hazards Models

KW - Public Health Surveillance

KW - Registries

KW - Risk

U2 - 10.1016/j.jaci.2015.07.040

DO - 10.1016/j.jaci.2015.07.040

M3 - Journal article

C2 - 26371844

VL - 137

SP - 587

EP - 590

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 2

ER -