Cerebral palsy and congenital malformations

Ester Garne, Helen Dolk, Inge Krägeloh-Mann, Susanne Holst Ravn, Christine Cans, SCPE Collaborative Group

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: Sep-17
OriginalsprogEngelsk
TidsskriftEuropean Journal of Paediatric Neurology
Vol/bind12
Udgave nummer2
Sider (fra-til)82-88
ISSN1090-3798
DOI
StatusUdgivet - 17. sep. 2007

Fingeraftryk

Cerebral Palsy
Databases
Population
Microcephaly
Skeleton
Registries
Kidney

Citer dette

Garne, E., Dolk, H., Krägeloh-Mann, I., Holst Ravn, S., Cans, C., & Collaborative Group, SCPE. (2007). Cerebral palsy and congenital malformations. European Journal of Paediatric Neurology, 12(2), 82-88. https://doi.org/10.1016/j.ejpn.2007.07.001
Garne, Ester ; Dolk, Helen ; Krägeloh-Mann, Inge ; Holst Ravn, Susanne ; Cans, Christine ; Collaborative Group, SCPE. / Cerebral palsy and congenital malformations. I: European Journal of Paediatric Neurology. 2007 ; Bind 12, Nr. 2. s. 82-88.
@article{77560d60d0f711dcb2ba000ea68e967b,
title = "Cerebral palsy and congenital malformations",
abstract = "AIM: To determine the proportion of children with cerebral palsy (CP) who have cerebral and non-cerebral congenital malformations. METHODS: Data from 11 CP registries contributing to the European Cerebral Palsy Database (SCPE), for children born in the period 1976-1996. The malformations were classified as recognized syndromes, chromosomal anomalies, cerebral malformations or non-cerebral malformations. Prevalence of malformations was compared to published data on livebirths from a European database of congenital malformations (EUROCAT). RESULTS: Overall 547 out of 4584 children (11.9{\%}) with CP were reported to have a congenital malformation. The majority (8.6{\%} of all children) were diagnosed with a cerebral malformation. The most frequent types of cerebral malformations were microcephaly and hydrocephaly. Non-cerebral malformations were present in 97 CP children and in further 14 CP children with cerebral malformations. The most frequent groups of non-cerebral malformations were cardiac, facial clefts and limb and skeleton malformations. Children born at term had a significantly higher prevalence of cerebral malformations compared to children born before 32 weeks (12.1{\%} versus 2.1{\%}, p<0.001). CONCLUSION: Cerebral malformations were much more frequent among children with CP than among all livebirths in the population. Malformations in organ systems close to the brain (eye, facial clefts) were more frequent in the CP population while malformations in organ systems further from the brain (renal, genital) were more frequent in the general population.",
author = "Ester Garne and Helen Dolk and Inge Kr{\"a}geloh-Mann and {Holst Ravn}, Susanne and Christine Cans and {Collaborative Group}, SCPE",
year = "2007",
month = "9",
day = "17",
doi = "10.1016/j.ejpn.2007.07.001",
language = "English",
volume = "12",
pages = "82--88",
journal = "European Journal of Paediatric Neurology",
issn = "1090-3798",
publisher = "Elsevier",
number = "2",

}

Garne, E, Dolk, H, Krägeloh-Mann, I, Holst Ravn, S, Cans, C & Collaborative Group, SCPE 2007, 'Cerebral palsy and congenital malformations', European Journal of Paediatric Neurology, bind 12, nr. 2, s. 82-88. https://doi.org/10.1016/j.ejpn.2007.07.001

Cerebral palsy and congenital malformations. / Garne, Ester; Dolk, Helen; Krägeloh-Mann, Inge; Holst Ravn, Susanne; Cans, Christine; Collaborative Group, SCPE.

I: European Journal of Paediatric Neurology, Bind 12, Nr. 2, 17.09.2007, s. 82-88.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Cerebral palsy and congenital malformations

AU - Garne, Ester

AU - Dolk, Helen

AU - Krägeloh-Mann, Inge

AU - Holst Ravn, Susanne

AU - Cans, Christine

AU - Collaborative Group, SCPE

PY - 2007/9/17

Y1 - 2007/9/17

N2 - AIM: To determine the proportion of children with cerebral palsy (CP) who have cerebral and non-cerebral congenital malformations. METHODS: Data from 11 CP registries contributing to the European Cerebral Palsy Database (SCPE), for children born in the period 1976-1996. The malformations were classified as recognized syndromes, chromosomal anomalies, cerebral malformations or non-cerebral malformations. Prevalence of malformations was compared to published data on livebirths from a European database of congenital malformations (EUROCAT). RESULTS: Overall 547 out of 4584 children (11.9%) with CP were reported to have a congenital malformation. The majority (8.6% of all children) were diagnosed with a cerebral malformation. The most frequent types of cerebral malformations were microcephaly and hydrocephaly. Non-cerebral malformations were present in 97 CP children and in further 14 CP children with cerebral malformations. The most frequent groups of non-cerebral malformations were cardiac, facial clefts and limb and skeleton malformations. Children born at term had a significantly higher prevalence of cerebral malformations compared to children born before 32 weeks (12.1% versus 2.1%, p<0.001). CONCLUSION: Cerebral malformations were much more frequent among children with CP than among all livebirths in the population. Malformations in organ systems close to the brain (eye, facial clefts) were more frequent in the CP population while malformations in organ systems further from the brain (renal, genital) were more frequent in the general population.

AB - AIM: To determine the proportion of children with cerebral palsy (CP) who have cerebral and non-cerebral congenital malformations. METHODS: Data from 11 CP registries contributing to the European Cerebral Palsy Database (SCPE), for children born in the period 1976-1996. The malformations were classified as recognized syndromes, chromosomal anomalies, cerebral malformations or non-cerebral malformations. Prevalence of malformations was compared to published data on livebirths from a European database of congenital malformations (EUROCAT). RESULTS: Overall 547 out of 4584 children (11.9%) with CP were reported to have a congenital malformation. The majority (8.6% of all children) were diagnosed with a cerebral malformation. The most frequent types of cerebral malformations were microcephaly and hydrocephaly. Non-cerebral malformations were present in 97 CP children and in further 14 CP children with cerebral malformations. The most frequent groups of non-cerebral malformations were cardiac, facial clefts and limb and skeleton malformations. Children born at term had a significantly higher prevalence of cerebral malformations compared to children born before 32 weeks (12.1% versus 2.1%, p<0.001). CONCLUSION: Cerebral malformations were much more frequent among children with CP than among all livebirths in the population. Malformations in organ systems close to the brain (eye, facial clefts) were more frequent in the CP population while malformations in organ systems further from the brain (renal, genital) were more frequent in the general population.

U2 - 10.1016/j.ejpn.2007.07.001

DO - 10.1016/j.ejpn.2007.07.001

M3 - Journal article

VL - 12

SP - 82

EP - 88

JO - European Journal of Paediatric Neurology

JF - European Journal of Paediatric Neurology

SN - 1090-3798

IS - 2

ER -

Garne E, Dolk H, Krägeloh-Mann I, Holst Ravn S, Cans C, Collaborative Group SCPE. Cerebral palsy and congenital malformations. European Journal of Paediatric Neurology. 2007 sep 17;12(2):82-88. https://doi.org/10.1016/j.ejpn.2007.07.001