Cell class-specific modulation of attentional signals by acetylcholine in macaque frontal eye field

Miguel Dasilva, Christian Brandt, Sascha Gotthardt, Marc Alwin Gieselmann, Claudia Distler, Alexander Thiele*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Attention is critical to high-level cognition, and attentional deficits are a hallmark of cognitive dysfunction. A key transmitter for attentional control is acetylcholine, but its cellular actions in attention-controlling areas remain poorly understood. Here we delineate how muscarinic and nicotinic receptors affect basic neuronal excitability and attentional control signals in different cell types in macaque frontal eye field. We found that broad spiking and narrow spiking cells both require muscarinic and nicotinic receptors for normal excitability, thereby affecting ongoing or stimulus-driven activity. Attentional control signals depended on muscarinic, not nicotinic receptors in broad spiking cells, while they depended on both muscarinic and nicotinic receptors in narrow spiking cells. Cluster analysis revealed that muscarinic and nicotinic effects on attentional control signals were highly selective even for different subclasses of narrow spiking cells and of broad spiking cells. These results demonstrate that cholinergic receptors are critical to establish attentional control signals in the frontal eye field in a cell type-specific manner.

OriginalsprogEngelsk
TidsskriftProceedings of the National Academy of Sciences of the United States of America
Vol/bind116
Udgave nummer40
Sider (fra-til)20180-20189
ISSN0027-8424
DOI
StatusUdgivet - 1. okt. 2019
Udgivet eksterntJa

Fingeraftryk

Acetylcholine
Muscarinic Receptors
Cholinergic Agents
Cholinergic Receptors
Cognition
Cluster Analysis

Citer dette

Dasilva, Miguel ; Brandt, Christian ; Gotthardt, Sascha ; Gieselmann, Marc Alwin ; Distler, Claudia ; Thiele, Alexander. / Cell class-specific modulation of attentional signals by acetylcholine in macaque frontal eye field. I: Proceedings of the National Academy of Sciences of the United States of America. 2019 ; Bind 116, Nr. 40. s. 20180-20189.
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Cell class-specific modulation of attentional signals by acetylcholine in macaque frontal eye field. / Dasilva, Miguel; Brandt, Christian; Gotthardt, Sascha; Gieselmann, Marc Alwin; Distler, Claudia; Thiele, Alexander.

I: Proceedings of the National Academy of Sciences of the United States of America, Bind 116, Nr. 40, 01.10.2019, s. 20180-20189.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Cell class-specific modulation of attentional signals by acetylcholine in macaque frontal eye field

AU - Dasilva, Miguel

AU - Brandt, Christian

AU - Gotthardt, Sascha

AU - Gieselmann, Marc Alwin

AU - Distler, Claudia

AU - Thiele, Alexander

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Attention is critical to high-level cognition, and attentional deficits are a hallmark of cognitive dysfunction. A key transmitter for attentional control is acetylcholine, but its cellular actions in attention-controlling areas remain poorly understood. Here we delineate how muscarinic and nicotinic receptors affect basic neuronal excitability and attentional control signals in different cell types in macaque frontal eye field. We found that broad spiking and narrow spiking cells both require muscarinic and nicotinic receptors for normal excitability, thereby affecting ongoing or stimulus-driven activity. Attentional control signals depended on muscarinic, not nicotinic receptors in broad spiking cells, while they depended on both muscarinic and nicotinic receptors in narrow spiking cells. Cluster analysis revealed that muscarinic and nicotinic effects on attentional control signals were highly selective even for different subclasses of narrow spiking cells and of broad spiking cells. These results demonstrate that cholinergic receptors are critical to establish attentional control signals in the frontal eye field in a cell type-specific manner.

AB - Attention is critical to high-level cognition, and attentional deficits are a hallmark of cognitive dysfunction. A key transmitter for attentional control is acetylcholine, but its cellular actions in attention-controlling areas remain poorly understood. Here we delineate how muscarinic and nicotinic receptors affect basic neuronal excitability and attentional control signals in different cell types in macaque frontal eye field. We found that broad spiking and narrow spiking cells both require muscarinic and nicotinic receptors for normal excitability, thereby affecting ongoing or stimulus-driven activity. Attentional control signals depended on muscarinic, not nicotinic receptors in broad spiking cells, while they depended on both muscarinic and nicotinic receptors in narrow spiking cells. Cluster analysis revealed that muscarinic and nicotinic effects on attentional control signals were highly selective even for different subclasses of narrow spiking cells and of broad spiking cells. These results demonstrate that cholinergic receptors are critical to establish attentional control signals in the frontal eye field in a cell type-specific manner.

KW - Acetylcholine

KW - Attention

KW - Frontal cortex

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M3 - Journal article

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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