Catalytic Staudinger Reduction at Room Temperature

Danny C. Lenstra, Joris J. Wolf, Jasmin Mecinović*

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Abstrakt

We report an efficient catalytic Staudinger reduction at room temperature that enables the preparation of a structurally diverse set of amines from azides in excellent yields. The reaction is based on the use of catalytic amounts of triphenylphosphine as a phosphine source and diphenyldisiloxane as a reducing agent. Our catalytic Staudinger reduction exhibits a high chemoselectivity, as exemplified by reduction of azides over other common functionalities, including nitriles, alkenes, alkynes, esters, and ketones.
OriginalsprogEngelsk
TidsskriftThe Journal of Organic Chemistry
Vol/bind84
Udgave nummer10
Sider (fra-til)6536-6545
ISSN0022-3263
DOI
StatusUdgivet - 17. maj 2019

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