Caspofungin Etest susceptibility testing of Candida species: risk of misclassification of susceptible isolates of C. glabrata and C. krusei when adopting the revised CLSI caspofungin breakpoints

Maiken Cavling Arendrup, Michael A Pfaller, Danish Fungaemia Study Group, Flemming Schønning Rosenvinge

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

The purpose of this study was to evaluate the performance of caspofungin Etest and the recently revised CLSI breakpoints. A total of 497 blood isolates, of which 496 were wild-type isolates, were included. A total of 65/496 susceptible isolates (13.1%) were misclassified as intermediate (I) or resistant (R). Such misclassifications were most commonly observed for Candida krusei (73.1%) and Candida glabrata (33.1%). The revised breakpoints cannot be safely adopted for these two species.
OriginalsprogEngelsk
TidsskriftAntimicrobial Agents and Chemotherapy
Vol/bind56
Udgave nummer7
Sider (fra-til)3965-8
Antal sider4
ISSN0066-4804
DOI
StatusUdgivet - 2012

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