Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test

A P Gjesing, L L Kjems, Marie Aare Vestmar, Niels Grarup, Allan René Linneberg, C F Deacon, J J Holst, O Pedersen, T Hansen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele associates with type 2 diabetes in several populations, possibly mediated via decreased incretin secretion and/or action and altered beta and alpha cell function. We aimed to study circulating levels of glucose, proinsulin, insulin, C-peptide, glucagon, glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2) and gastric inhibitory polypeptide (GIP) among individuals carrying the high-risk rs7903146 TT genotype and low-risk CC genotype following a meal test.
OriginalsprogEngelsk
TidsskriftDiabetologia
Vol/bind54
Udgave nummer1
Sider (fra-til)103-10
Antal sider8
ISSN0012-186X
DOI
StatusUdgivet - 2011

Fingeraftryk

T Cell Transcription Factor 1
Gastric Inhibitory Polypeptide
Proinsulin
Meals
Glucagon-Like Peptide 2
Glucagon
Serum
Type 2 Diabetes Mellitus
Alleles
Insulin
Population

Citer dette

Gjesing, A P ; Kjems, L L ; Vestmar, Marie Aare ; Grarup, Niels ; Linneberg, Allan René ; Deacon, C F ; Holst, J J ; Pedersen, O ; Hansen, T. / Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test. I: Diabetologia. 2011 ; Bind 54, Nr. 1. s. 103-10.
@article{ac6d2dbe22db498a83fdc8408395f464,
title = "Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test",
abstract = "The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele associates with type 2 diabetes in several populations, possibly mediated via decreased incretin secretion and/or action and altered beta and alpha cell function. We aimed to study circulating levels of glucose, proinsulin, insulin, C-peptide, glucagon, glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2) and gastric inhibitory polypeptide (GIP) among individuals carrying the high-risk rs7903146 TT genotype and low-risk CC genotype following a meal test.",
keywords = "Alleles, Blood Glucose, Gastric Inhibitory Polypeptide, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Proinsulin, Transcription Factor 7-Like 2 Protein",
author = "Gjesing, {A P} and Kjems, {L L} and Vestmar, {Marie Aare} and Niels Grarup and Linneberg, {Allan Ren{\'e}} and Deacon, {C F} and Holst, {J J} and O Pedersen and T Hansen",
year = "2011",
doi = "10.1007/s00125-010-1940-4",
language = "English",
volume = "54",
pages = "103--10",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Heinemann",
number = "1",

}

Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test. / Gjesing, A P; Kjems, L L; Vestmar, Marie Aare; Grarup, Niels; Linneberg, Allan René; Deacon, C F; Holst, J J; Pedersen, O; Hansen, T.

I: Diabetologia, Bind 54, Nr. 1, 2011, s. 103-10.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test

AU - Gjesing, A P

AU - Kjems, L L

AU - Vestmar, Marie Aare

AU - Grarup, Niels

AU - Linneberg, Allan René

AU - Deacon, C F

AU - Holst, J J

AU - Pedersen, O

AU - Hansen, T

PY - 2011

Y1 - 2011

N2 - The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele associates with type 2 diabetes in several populations, possibly mediated via decreased incretin secretion and/or action and altered beta and alpha cell function. We aimed to study circulating levels of glucose, proinsulin, insulin, C-peptide, glucagon, glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2) and gastric inhibitory polypeptide (GIP) among individuals carrying the high-risk rs7903146 TT genotype and low-risk CC genotype following a meal test.

AB - The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele associates with type 2 diabetes in several populations, possibly mediated via decreased incretin secretion and/or action and altered beta and alpha cell function. We aimed to study circulating levels of glucose, proinsulin, insulin, C-peptide, glucagon, glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2) and gastric inhibitory polypeptide (GIP) among individuals carrying the high-risk rs7903146 TT genotype and low-risk CC genotype following a meal test.

KW - Alleles

KW - Blood Glucose

KW - Gastric Inhibitory Polypeptide

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Proinsulin

KW - Transcription Factor 7-Like 2 Protein

U2 - 10.1007/s00125-010-1940-4

DO - 10.1007/s00125-010-1940-4

M3 - Journal article

VL - 54

SP - 103

EP - 110

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 1

ER -