Cardiac troponin T and CK-MB mass release after visually successful percutaneous transluminal coronary angioplasty in stable angina pectoris

J Ravkilde, H Nissen, H Mickley, P E Andersen, P Thayssen, M Hørder

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 1994-Jan
OriginalsprogEngelsk
TidsskriftAmerican Heart Journal
Vol/bind127
Udgave nummer1
Sider (fra-til)13-20
Antal sider7
ISSN0002-8703
StatusUdgivet - 1. jan. 1994

Fingeraftryk

MB Form Creatine Kinase
Troponin T
Coronary Balloon Angioplasty
Stable Angina
Isoenzymes
Coronary Atherectomy
L-Lactate Dehydrogenase
Pathologic Constriction
Incidence

Citer dette

@article{f0cc069046fc11df937d000ea68e967b,
title = "Cardiac troponin T and CK-MB mass release after visually successful percutaneous transluminal coronary angioplasty in stable angina pectoris",
abstract = "The incidence of cardiac troponin T (Tn-T) and creatine kinase (CK) isoenzyme MB mass release was studied in 23 patients with stable angina pectoris undergoing visually successful percutaneous transluminal coronary angioplasty (PTCA). Serial blood samples were drawn for measurement of serum Tn-T, CK-MB mass, total CK activity, CK-MB activity, and lactate dehydrogenase isoenzyme (LD-1). ST segment monitoring was carried out during PTCA and for the following 24 hours. None of the patients showed electrocardiographic (ECG) evidence of myocardial infarction. However, Tn-T was elevated in three patients (0.23 to 1.32 micrograms/L), and in these three and an additional three patients CK-MB mass was also elevated (7.0 to 27.5 micrograms/L). Total CK activity and LD-1 were only elevated in one of these six patients. None had elevated CK-MB activity. ST segment depression on ECG recording was not predictive of Tn-T or CK-MB mass release. Patients with elevated Tn-T or CK-MB mass did not differ with respect to demographic data, stenosis characteristics, or in the PTCA procedure. We conclude that CK-MB mass uncovers clinically and ambulatory electrocardiographically inapparent severe myocardial ischemia/minor myocardial damage (microembolization) in 26{\%} (6 of 23) of patients after visually successful PTCA; 13{\%} (3 of 23) had elevated Tn-T, indicating minor myocardial damage. The application of these markers in the future could be of considerable value for determining the efficacy of coronary angioplasty and atherectomy, as well as for drug therapy in connection with such procedures.",
keywords = "Adult, Aged, Angina Pectoris, Angioplasty, Transluminal, Percutaneous Coronary, Biological Markers, Cardiomyopathies, Creatine Kinase, Electrocardiography, Female, Humans, Isoenzymes, Male, Middle Aged, Myocardial Ischemia, Troponin, Troponin T",
author = "J Ravkilde and H Nissen and H Mickley and Andersen, {P E} and P Thayssen and M H{\o}rder",
year = "1994",
month = "1",
day = "1",
language = "English",
volume = "127",
pages = "13--20",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby, Inc.",
number = "1",

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Cardiac troponin T and CK-MB mass release after visually successful percutaneous transluminal coronary angioplasty in stable angina pectoris. / Ravkilde, J; Nissen, H; Mickley, H; Andersen, P E; Thayssen, P; Hørder, M.

I: American Heart Journal, Bind 127, Nr. 1, 01.01.1994, s. 13-20.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Cardiac troponin T and CK-MB mass release after visually successful percutaneous transluminal coronary angioplasty in stable angina pectoris

AU - Ravkilde, J

AU - Nissen, H

AU - Mickley, H

AU - Andersen, P E

AU - Thayssen, P

AU - Hørder, M

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The incidence of cardiac troponin T (Tn-T) and creatine kinase (CK) isoenzyme MB mass release was studied in 23 patients with stable angina pectoris undergoing visually successful percutaneous transluminal coronary angioplasty (PTCA). Serial blood samples were drawn for measurement of serum Tn-T, CK-MB mass, total CK activity, CK-MB activity, and lactate dehydrogenase isoenzyme (LD-1). ST segment monitoring was carried out during PTCA and for the following 24 hours. None of the patients showed electrocardiographic (ECG) evidence of myocardial infarction. However, Tn-T was elevated in three patients (0.23 to 1.32 micrograms/L), and in these three and an additional three patients CK-MB mass was also elevated (7.0 to 27.5 micrograms/L). Total CK activity and LD-1 were only elevated in one of these six patients. None had elevated CK-MB activity. ST segment depression on ECG recording was not predictive of Tn-T or CK-MB mass release. Patients with elevated Tn-T or CK-MB mass did not differ with respect to demographic data, stenosis characteristics, or in the PTCA procedure. We conclude that CK-MB mass uncovers clinically and ambulatory electrocardiographically inapparent severe myocardial ischemia/minor myocardial damage (microembolization) in 26% (6 of 23) of patients after visually successful PTCA; 13% (3 of 23) had elevated Tn-T, indicating minor myocardial damage. The application of these markers in the future could be of considerable value for determining the efficacy of coronary angioplasty and atherectomy, as well as for drug therapy in connection with such procedures.

AB - The incidence of cardiac troponin T (Tn-T) and creatine kinase (CK) isoenzyme MB mass release was studied in 23 patients with stable angina pectoris undergoing visually successful percutaneous transluminal coronary angioplasty (PTCA). Serial blood samples were drawn for measurement of serum Tn-T, CK-MB mass, total CK activity, CK-MB activity, and lactate dehydrogenase isoenzyme (LD-1). ST segment monitoring was carried out during PTCA and for the following 24 hours. None of the patients showed electrocardiographic (ECG) evidence of myocardial infarction. However, Tn-T was elevated in three patients (0.23 to 1.32 micrograms/L), and in these three and an additional three patients CK-MB mass was also elevated (7.0 to 27.5 micrograms/L). Total CK activity and LD-1 were only elevated in one of these six patients. None had elevated CK-MB activity. ST segment depression on ECG recording was not predictive of Tn-T or CK-MB mass release. Patients with elevated Tn-T or CK-MB mass did not differ with respect to demographic data, stenosis characteristics, or in the PTCA procedure. We conclude that CK-MB mass uncovers clinically and ambulatory electrocardiographically inapparent severe myocardial ischemia/minor myocardial damage (microembolization) in 26% (6 of 23) of patients after visually successful PTCA; 13% (3 of 23) had elevated Tn-T, indicating minor myocardial damage. The application of these markers in the future could be of considerable value for determining the efficacy of coronary angioplasty and atherectomy, as well as for drug therapy in connection with such procedures.

KW - Adult

KW - Aged

KW - Angina Pectoris

KW - Angioplasty, Transluminal, Percutaneous Coronary

KW - Biological Markers

KW - Cardiomyopathies

KW - Creatine Kinase

KW - Electrocardiography

KW - Female

KW - Humans

KW - Isoenzymes

KW - Male

KW - Middle Aged

KW - Myocardial Ischemia

KW - Troponin

KW - Troponin T

M3 - Journal article

VL - 127

SP - 13

EP - 20

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

IS - 1

ER -