Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles

Refaat B. Hamed, Jasmin Mecinović, Christian Ducho, T. D W Claridge, Christopher J. Schofield

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Abstrakt

The utility of wild-type and variant carboxymethylproline synthases for biocatalysis was demonstrated by preparing functionalised 5-, 6- and 7-membered N-heterocycles from amino acid aldehydes and (alkylated) malonyl-coenzyme A derivatives; the N-heterocycles produced were converted to the corresponding bicyclic β-lactams by a carbapenem synthetase.

OriginalsprogEngelsk
TidsskriftChemical Communications
Vol/bind46
Udgave nummer9
Sider (fra-til)1413-1415
Antal sider3
ISSN1359-7345
DOI
StatusUdgivet - 24. feb. 2010
Udgivet eksterntJa

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