Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance

Filippo P D'Andrea; Akmal Safwat; Moustapha Kassem; Laurant Gautier; Jens Overgaard; Michael Robert Horsman

doi:10.1016/j.radonc.2011.05.086

Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance

Filippo P D'Andrea
, Akmal Safwat
, Moustapha Kassem
, Laurant Gautier
, Jens Overgaard
, Michael Robert Horsman

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Cancer stem cells are thought to be a radioresistant population and may be the seeds for recurrence after radiotherapy. Using tumorigenic clones of retroviral immortalized human mesenchymal stem cell with small differences in their phenotype, we investigated possible genetic expression that could explain cancer stem cell radiation resistance.

Originalsprog	Engelsk
Tidsskrift	Radiotherapy & Oncology
Vol/bind	99
Udgave nummer	3
Sider (fra-til)	373-8
Antal sider	6
ISSN	0167-8140
DOI	https://doi.org/10.1016/j.radonc.2011.05.086
Status	Udgivet - 1. jun. 2011

Dokumenter og links

10.1016/j.radonc.2011.05.086

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Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

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title = "Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance",

abstract = "Cancer stem cells are thought to be a radioresistant population and may be the seeds for recurrence after radiotherapy. Using tumorigenic clones of retroviral immortalized human mesenchymal stem cell with small differences in their phenotype, we investigated possible genetic expression that could explain cancer stem cell radiation resistance.",

keywords = "Cell Cycle, Chromosome Aberrations, Cytokines, Exons, Gene Expression, Humans, Mesenchymal Stem Cells, Neoplastic Stem Cells, Nicotinamide N-Methyltransferase, Nicotinamide Phosphoribosyltransferase, Phenotype, Radiation Tolerance, Real-Time Polymerase Chain Reaction, Up-Regulation",

author = "D'Andrea, \{Filippo P\} and Akmal Safwat and Moustapha Kassem and Laurant Gautier and Jens Overgaard and Horsman, \{Michael Robert\}",

year = "2011",

month = jun,

day = "1",

doi = "10.1016/j.radonc.2011.05.086",

language = "English",

volume = "99",

pages = "373--8",

journal = "Radiotherapy \& Oncology",

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TY - JOUR

T1 - Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance

AU - D'Andrea, Filippo P

AU - Safwat, Akmal

AU - Kassem, Moustapha

AU - Gautier, Laurant

AU - Overgaard, Jens

AU - Horsman, Michael Robert

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Cancer stem cells are thought to be a radioresistant population and may be the seeds for recurrence after radiotherapy. Using tumorigenic clones of retroviral immortalized human mesenchymal stem cell with small differences in their phenotype, we investigated possible genetic expression that could explain cancer stem cell radiation resistance.

AB - Cancer stem cells are thought to be a radioresistant population and may be the seeds for recurrence after radiotherapy. Using tumorigenic clones of retroviral immortalized human mesenchymal stem cell with small differences in their phenotype, we investigated possible genetic expression that could explain cancer stem cell radiation resistance.

KW - Cell Cycle

KW - Chromosome Aberrations

KW - Cytokines

KW - Exons

KW - Gene Expression

KW - Humans

KW - Mesenchymal Stem Cells

KW - Neoplastic Stem Cells

KW - Nicotinamide N-Methyltransferase

KW - Nicotinamide Phosphoribosyltransferase

KW - Phenotype

KW - Radiation Tolerance

KW - Real-Time Polymerase Chain Reaction

KW - Up-Regulation

U2 - 10.1016/j.radonc.2011.05.086

DO - 10.1016/j.radonc.2011.05.086

M3 - Journal article

C2 - 21719135

SN - 0167-8140

VL - 99

SP - 373

EP - 378

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

IS - 3

ER -

Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance

Abstract

Dokumenter og links

SDU link

Fingeraftryk

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