Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance

Filippo P D'Andrea, Akmal Safwat, Moustapha Kassem, Laurant Gautier, Jens Overgaard, Michael Robert Horsman

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Cancer stem cells are thought to be a radioresistant population and may be the seeds for recurrence after radiotherapy. Using tumorigenic clones of retroviral immortalized human mesenchymal stem cell with small differences in their phenotype, we investigated possible genetic expression that could explain cancer stem cell radiation resistance.
OriginalsprogEngelsk
TidsskriftRadiotherapy & Oncology
Vol/bind99
Udgave nummer3
Sider (fra-til)373-8
Antal sider6
ISSN0167-8140
DOI
StatusUdgivet - 1. jun. 2011

Fingeraftryk

Mesenchymal Stromal Cells
Seeds
Clone Cells
Population

Citer dette

D'Andrea, Filippo P ; Safwat, Akmal ; Kassem, Moustapha ; Gautier, Laurant ; Overgaard, Jens ; Horsman, Michael Robert. / Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance. I: Radiotherapy & Oncology. 2011 ; Bind 99, Nr. 3. s. 373-8.
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keywords = "Cell Cycle, Chromosome Aberrations, Cytokines, Exons, Gene Expression, Humans, Mesenchymal Stem Cells, Neoplastic Stem Cells, Nicotinamide N-Methyltransferase, Nicotinamide Phosphoribosyltransferase, Phenotype, Radiation Tolerance, Real-Time Polymerase Chain Reaction, Up-Regulation",
author = "D'Andrea, {Filippo P} and Akmal Safwat and Moustapha Kassem and Laurant Gautier and Jens Overgaard and Horsman, {Michael Robert}",
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Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance. / D'Andrea, Filippo P; Safwat, Akmal; Kassem, Moustapha; Gautier, Laurant; Overgaard, Jens; Horsman, Michael Robert.

I: Radiotherapy & Oncology, Bind 99, Nr. 3, 01.06.2011, s. 373-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance

AU - D'Andrea, Filippo P

AU - Safwat, Akmal

AU - Kassem, Moustapha

AU - Gautier, Laurant

AU - Overgaard, Jens

AU - Horsman, Michael Robert

N1 - Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Cancer stem cells are thought to be a radioresistant population and may be the seeds for recurrence after radiotherapy. Using tumorigenic clones of retroviral immortalized human mesenchymal stem cell with small differences in their phenotype, we investigated possible genetic expression that could explain cancer stem cell radiation resistance.

AB - Cancer stem cells are thought to be a radioresistant population and may be the seeds for recurrence after radiotherapy. Using tumorigenic clones of retroviral immortalized human mesenchymal stem cell with small differences in their phenotype, we investigated possible genetic expression that could explain cancer stem cell radiation resistance.

KW - Cell Cycle

KW - Chromosome Aberrations

KW - Cytokines

KW - Exons

KW - Gene Expression

KW - Humans

KW - Mesenchymal Stem Cells

KW - Neoplastic Stem Cells

KW - Nicotinamide N-Methyltransferase

KW - Nicotinamide Phosphoribosyltransferase

KW - Phenotype

KW - Radiation Tolerance

KW - Real-Time Polymerase Chain Reaction

KW - Up-Regulation

U2 - 10.1016/j.radonc.2011.05.086

DO - 10.1016/j.radonc.2011.05.086

M3 - Journal article

C2 - 21719135

VL - 99

SP - 373

EP - 378

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

SN - 0167-8140

IS - 3

ER -