Cancer Incidence and Mortality in 260,000 Nordic Twins With 30,000 Prospective Cancers

Axel Skytthe, Jennifer R Harris, Kamila Czene, Lorelei Mucci, Hans-Olov Adami, Kaare Christensen, Jacob Hjelmborg, Niels V Holm, Thomas S Nilsen, Jaakko Kaprio, Eero Pukkala

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The Nordic countries have comprehensive, population-based health and medical registries linkable on individually unique personal identity codes, enabling complete long-term follow-up. The aims of this study were to describe the NorTwinCan cohort established in 2010 and assess whether the cancer mortality and incidence rates among Nordic twins are similar to those in the general population. We analyzed approximately 260,000 same-sexed twins in the nationwide twin registers in Denmark, Finland, Norway and Sweden. Cancer incidence was determined using follow-up through the national cancer registries. We estimated standardized incidence (SIR) and mortality (SMR) ratios with 95% confidence intervals (CI) across country, age, period, follow-up time, sex and zygosity. More than 30,000 malignant neoplasms have occurred among the twins through 2010. Mortality rates among twins were slightly lower than in the general population (SMR 0.96; CI 95% [0.95, 0.97]), but this depends on information about zygosity. Twins have slightly lower cancer incidence rates than the general population, with SIRs of 0.97 (95% CI [0.96, 0.99]) in men and 0.96 (95% CI [0.94, 0.97]) in women. Testicular cancer occurs more often among male twins than singletons (SIR 1.15; 95% CI [1.02, 1.30]), while cancers of the kidney (SIR 0.82; 95% CI [0.76, 0.89]), lung (SIR 0.89; 95% CI [0.85, 0.92]) and colon (SIR 0.90; 95% CI [0.87, 0.94]) occur less often in twins than in the background population. Our findings indicate that the risk of cancer among twins is so similar to the general population that cancer risk factors and estimates of heritability derived from the Nordic twin registers are generalizable to the background populations.
OriginalsprogEngelsk
TidsskriftTwin Research and Human Genetics
Vol/bind22
Udgave nummer2
Sider (fra-til)99-107
ISSN1832-4274
DOI
StatusUdgivet - apr. 2019

Fingeraftryk

Confidence Intervals
Incidence
Neoplasms
Population
Registries
Scandinavian and Nordic Countries
Kidney Neoplasms
Denmark
Finland
Norway
Colon
Lung
Health

Emneord

  • Twins
  • cancer incidence
  • cohort study
  • record linkage
  • selection

Citer dette

Skytthe, Axel ; Harris, Jennifer R ; Czene, Kamila ; Mucci, Lorelei ; Adami, Hans-Olov ; Christensen, Kaare ; Hjelmborg, Jacob ; Holm, Niels V ; Nilsen, Thomas S ; Kaprio, Jaakko ; Pukkala, Eero. / Cancer Incidence and Mortality in 260,000 Nordic Twins With 30,000 Prospective Cancers. I: Twin Research and Human Genetics. 2019 ; Bind 22, Nr. 2. s. 99-107.
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abstract = "The Nordic countries have comprehensive, population-based health and medical registries linkable on individually unique personal identity codes, enabling complete long-term follow-up. The aims of this study were to describe the NorTwinCan cohort established in 2010 and assess whether the cancer mortality and incidence rates among Nordic twins are similar to those in the general population. We analyzed approximately 260,000 same-sexed twins in the nationwide twin registers in Denmark, Finland, Norway and Sweden. Cancer incidence was determined using follow-up through the national cancer registries. We estimated standardized incidence (SIR) and mortality (SMR) ratios with 95{\%} confidence intervals (CI) across country, age, period, follow-up time, sex and zygosity. More than 30,000 malignant neoplasms have occurred among the twins through 2010. Mortality rates among twins were slightly lower than in the general population (SMR 0.96; CI 95{\%} [0.95, 0.97]), but this depends on information about zygosity. Twins have slightly lower cancer incidence rates than the general population, with SIRs of 0.97 (95{\%} CI [0.96, 0.99]) in men and 0.96 (95{\%} CI [0.94, 0.97]) in women. Testicular cancer occurs more often among male twins than singletons (SIR 1.15; 95{\%} CI [1.02, 1.30]), while cancers of the kidney (SIR 0.82; 95{\%} CI [0.76, 0.89]), lung (SIR 0.89; 95{\%} CI [0.85, 0.92]) and colon (SIR 0.90; 95{\%} CI [0.87, 0.94]) occur less often in twins than in the background population. Our findings indicate that the risk of cancer among twins is so similar to the general population that cancer risk factors and estimates of heritability derived from the Nordic twin registers are generalizable to the background populations.",
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Cancer Incidence and Mortality in 260,000 Nordic Twins With 30,000 Prospective Cancers. / Skytthe, Axel; Harris, Jennifer R; Czene, Kamila; Mucci, Lorelei; Adami, Hans-Olov; Christensen, Kaare; Hjelmborg, Jacob; Holm, Niels V; Nilsen, Thomas S; Kaprio, Jaakko; Pukkala, Eero.

I: Twin Research and Human Genetics, Bind 22, Nr. 2, 04.2019, s. 99-107.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Cancer Incidence and Mortality in 260,000 Nordic Twins With 30,000 Prospective Cancers

AU - Skytthe, Axel

AU - Harris, Jennifer R

AU - Czene, Kamila

AU - Mucci, Lorelei

AU - Adami, Hans-Olov

AU - Christensen, Kaare

AU - Hjelmborg, Jacob

AU - Holm, Niels V

AU - Nilsen, Thomas S

AU - Kaprio, Jaakko

AU - Pukkala, Eero

PY - 2019/4

Y1 - 2019/4

N2 - The Nordic countries have comprehensive, population-based health and medical registries linkable on individually unique personal identity codes, enabling complete long-term follow-up. The aims of this study were to describe the NorTwinCan cohort established in 2010 and assess whether the cancer mortality and incidence rates among Nordic twins are similar to those in the general population. We analyzed approximately 260,000 same-sexed twins in the nationwide twin registers in Denmark, Finland, Norway and Sweden. Cancer incidence was determined using follow-up through the national cancer registries. We estimated standardized incidence (SIR) and mortality (SMR) ratios with 95% confidence intervals (CI) across country, age, period, follow-up time, sex and zygosity. More than 30,000 malignant neoplasms have occurred among the twins through 2010. Mortality rates among twins were slightly lower than in the general population (SMR 0.96; CI 95% [0.95, 0.97]), but this depends on information about zygosity. Twins have slightly lower cancer incidence rates than the general population, with SIRs of 0.97 (95% CI [0.96, 0.99]) in men and 0.96 (95% CI [0.94, 0.97]) in women. Testicular cancer occurs more often among male twins than singletons (SIR 1.15; 95% CI [1.02, 1.30]), while cancers of the kidney (SIR 0.82; 95% CI [0.76, 0.89]), lung (SIR 0.89; 95% CI [0.85, 0.92]) and colon (SIR 0.90; 95% CI [0.87, 0.94]) occur less often in twins than in the background population. Our findings indicate that the risk of cancer among twins is so similar to the general population that cancer risk factors and estimates of heritability derived from the Nordic twin registers are generalizable to the background populations.

AB - The Nordic countries have comprehensive, population-based health and medical registries linkable on individually unique personal identity codes, enabling complete long-term follow-up. The aims of this study were to describe the NorTwinCan cohort established in 2010 and assess whether the cancer mortality and incidence rates among Nordic twins are similar to those in the general population. We analyzed approximately 260,000 same-sexed twins in the nationwide twin registers in Denmark, Finland, Norway and Sweden. Cancer incidence was determined using follow-up through the national cancer registries. We estimated standardized incidence (SIR) and mortality (SMR) ratios with 95% confidence intervals (CI) across country, age, period, follow-up time, sex and zygosity. More than 30,000 malignant neoplasms have occurred among the twins through 2010. Mortality rates among twins were slightly lower than in the general population (SMR 0.96; CI 95% [0.95, 0.97]), but this depends on information about zygosity. Twins have slightly lower cancer incidence rates than the general population, with SIRs of 0.97 (95% CI [0.96, 0.99]) in men and 0.96 (95% CI [0.94, 0.97]) in women. Testicular cancer occurs more often among male twins than singletons (SIR 1.15; 95% CI [1.02, 1.30]), while cancers of the kidney (SIR 0.82; 95% CI [0.76, 0.89]), lung (SIR 0.89; 95% CI [0.85, 0.92]) and colon (SIR 0.90; 95% CI [0.87, 0.94]) occur less often in twins than in the background population. Our findings indicate that the risk of cancer among twins is so similar to the general population that cancer risk factors and estimates of heritability derived from the Nordic twin registers are generalizable to the background populations.

KW - Twins

KW - cancer incidence

KW - cohort study

KW - record linkage

KW - selection

KW - Twins

KW - cancer incidence

KW - cohort study

KW - record linkage

KW - selection

U2 - 10.1017/thg.2019.10

DO - 10.1017/thg.2019.10

M3 - Journal article

VL - 22

SP - 99

EP - 107

JO - Twin Research and Human Genetics

JF - Twin Research and Human Genetics

SN - 1832-4274

IS - 2

ER -