Can the Ni classification of vessels predict neoplasia?

A systematic review and meta-analysis

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Resumé

Objectives: The Ni classification of vascular change from 2011 is well documented for evaluating pharyngeal and laryngeal lesions, primarily focusing on cancer. In the planning of surgery it may be more relevant to differentiate neoplasia from non-neoplasia. We aimed to evaluate the ability of the Ni classification to predict laryngeal or hypopharyngeal neoplasia and to investigate if a changed cutoff value would support the recent European Laryngological Society (ELS) proposal of perpendicular vascular changes as indicative of neoplasia. Data Sources: PubMed, Embase, Cochrane, and Scopus databases. Review Methods: A systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. We systematically searched for publications from 2011 until 2016. All retrieved studies were reviewed and qualitatively assessed. The pooled sensitivity and specificity of the Ni classification with two different cutoffs were calculated, and bubble and summary receiver operating characteristics plots were created. Results: The combined sensitivity of five studies (n = 687) with Ni type IV-V defined as test-positive was 0.89 (95% confidence interval [CI]: 0.76-0.95), and specificity was 0.82 (95% CI: 0.72-0.89). The equivalent combined sensitivity of four studies (n = 624) with Ni type V defined as test-positive was 0.82 (95% CI: 0.75-0.87), and specificity was 0.93 (95% CI: 0.82-0.97). Conclusions: The diagnostic accuracy of the Ni classification in predicting neoplasia was high, without significant difference between the two analyzed cutoff values. Implementation of the proposed ELS classification of vascular changes seems reasonable from a clinical perspective, with comparable accuracy. Attention must be drawn to the accompanying risk of exposing patients to unnecessary surgery. Laryngoscope, 128:168–176, 2018.

OriginalsprogEngelsk
TidsskriftThe Laryngoscope
Vol/bind128
Udgave nummer1
Sider (fra-til)168–176
ISSN0023-852X
DOI
StatusUdgivet - jan. 2018

Fingeraftryk

Meta-Analysis
Confidence Intervals
Neoplasms
Unnecessary Procedures
Laryngoscopes
Information Storage and Retrieval
PubMed
ROC Curve
Publications
Databases

Citer dette

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title = "Can the Ni classification of vessels predict neoplasia?: A systematic review and meta-analysis",
abstract = "Objectives: The Ni classification of vascular change from 2011 is well documented for evaluating pharyngeal and laryngeal lesions, primarily focusing on cancer. In the planning of surgery it may be more relevant to differentiate neoplasia from non-neoplasia. We aimed to evaluate the ability of the Ni classification to predict laryngeal or hypopharyngeal neoplasia and to investigate if a changed cutoff value would support the recent European Laryngological Society (ELS) proposal of perpendicular vascular changes as indicative of neoplasia. Data Sources: PubMed, Embase, Cochrane, and Scopus databases. Review Methods: A systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. We systematically searched for publications from 2011 until 2016. All retrieved studies were reviewed and qualitatively assessed. The pooled sensitivity and specificity of the Ni classification with two different cutoffs were calculated, and bubble and summary receiver operating characteristics plots were created. Results: The combined sensitivity of five studies (n = 687) with Ni type IV-V defined as test-positive was 0.89 (95{\%} confidence interval [CI]: 0.76-0.95), and specificity was 0.82 (95{\%} CI: 0.72-0.89). The equivalent combined sensitivity of four studies (n = 624) with Ni type V defined as test-positive was 0.82 (95{\%} CI: 0.75-0.87), and specificity was 0.93 (95{\%} CI: 0.82-0.97). Conclusions: The diagnostic accuracy of the Ni classification in predicting neoplasia was high, without significant difference between the two analyzed cutoff values. Implementation of the proposed ELS classification of vascular changes seems reasonable from a clinical perspective, with comparable accuracy. Attention must be drawn to the accompanying risk of exposing patients to unnecessary surgery. Laryngoscope, 128:168–176, 2018.",
keywords = "Early Detection of Cancer, Humans, Hypopharyngeal Neoplasms/diagnostic imaging, Laryngeal Neoplasms/diagnostic imaging, Microvessels/diagnostic imaging, Narrow Band Imaging, Precancerous Conditions/diagnostic imaging, Predictive Value of Tests, Sensitivity and Specificity",
author = "Mehlum, {Camilla Slot} and Tine Rosenberg and Anne-Kirstine Dyrvig and Groentved, {Aagot Moeller} and Thomas Kj{\ae}rgaard and Christian Godballe",
note = "{\circledC} 2017 The American Laryngological, Rhinological and Otological Society, Inc.",
year = "2018",
month = "1",
doi = "10.1002/lary.26721",
language = "English",
volume = "128",
pages = "168–176",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "JohnWiley & Sons, Inc.",
number = "1",

}

TY - JOUR

T1 - Can the Ni classification of vessels predict neoplasia?

T2 - A systematic review and meta-analysis

AU - Mehlum, Camilla Slot

AU - Rosenberg, Tine

AU - Dyrvig, Anne-Kirstine

AU - Groentved, Aagot Moeller

AU - Kjærgaard, Thomas

AU - Godballe, Christian

N1 - © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

PY - 2018/1

Y1 - 2018/1

N2 - Objectives: The Ni classification of vascular change from 2011 is well documented for evaluating pharyngeal and laryngeal lesions, primarily focusing on cancer. In the planning of surgery it may be more relevant to differentiate neoplasia from non-neoplasia. We aimed to evaluate the ability of the Ni classification to predict laryngeal or hypopharyngeal neoplasia and to investigate if a changed cutoff value would support the recent European Laryngological Society (ELS) proposal of perpendicular vascular changes as indicative of neoplasia. Data Sources: PubMed, Embase, Cochrane, and Scopus databases. Review Methods: A systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. We systematically searched for publications from 2011 until 2016. All retrieved studies were reviewed and qualitatively assessed. The pooled sensitivity and specificity of the Ni classification with two different cutoffs were calculated, and bubble and summary receiver operating characteristics plots were created. Results: The combined sensitivity of five studies (n = 687) with Ni type IV-V defined as test-positive was 0.89 (95% confidence interval [CI]: 0.76-0.95), and specificity was 0.82 (95% CI: 0.72-0.89). The equivalent combined sensitivity of four studies (n = 624) with Ni type V defined as test-positive was 0.82 (95% CI: 0.75-0.87), and specificity was 0.93 (95% CI: 0.82-0.97). Conclusions: The diagnostic accuracy of the Ni classification in predicting neoplasia was high, without significant difference between the two analyzed cutoff values. Implementation of the proposed ELS classification of vascular changes seems reasonable from a clinical perspective, with comparable accuracy. Attention must be drawn to the accompanying risk of exposing patients to unnecessary surgery. Laryngoscope, 128:168–176, 2018.

AB - Objectives: The Ni classification of vascular change from 2011 is well documented for evaluating pharyngeal and laryngeal lesions, primarily focusing on cancer. In the planning of surgery it may be more relevant to differentiate neoplasia from non-neoplasia. We aimed to evaluate the ability of the Ni classification to predict laryngeal or hypopharyngeal neoplasia and to investigate if a changed cutoff value would support the recent European Laryngological Society (ELS) proposal of perpendicular vascular changes as indicative of neoplasia. Data Sources: PubMed, Embase, Cochrane, and Scopus databases. Review Methods: A systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. We systematically searched for publications from 2011 until 2016. All retrieved studies were reviewed and qualitatively assessed. The pooled sensitivity and specificity of the Ni classification with two different cutoffs were calculated, and bubble and summary receiver operating characteristics plots were created. Results: The combined sensitivity of five studies (n = 687) with Ni type IV-V defined as test-positive was 0.89 (95% confidence interval [CI]: 0.76-0.95), and specificity was 0.82 (95% CI: 0.72-0.89). The equivalent combined sensitivity of four studies (n = 624) with Ni type V defined as test-positive was 0.82 (95% CI: 0.75-0.87), and specificity was 0.93 (95% CI: 0.82-0.97). Conclusions: The diagnostic accuracy of the Ni classification in predicting neoplasia was high, without significant difference between the two analyzed cutoff values. Implementation of the proposed ELS classification of vascular changes seems reasonable from a clinical perspective, with comparable accuracy. Attention must be drawn to the accompanying risk of exposing patients to unnecessary surgery. Laryngoscope, 128:168–176, 2018.

KW - Early Detection of Cancer

KW - Humans

KW - Hypopharyngeal Neoplasms/diagnostic imaging

KW - Laryngeal Neoplasms/diagnostic imaging

KW - Microvessels/diagnostic imaging

KW - Narrow Band Imaging

KW - Precancerous Conditions/diagnostic imaging

KW - Predictive Value of Tests

KW - Sensitivity and Specificity

U2 - 10.1002/lary.26721

DO - 10.1002/lary.26721

M3 - Review

VL - 128

SP - 168

EP - 176

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 1

ER -