Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?

Tue Kjølhede, Susanne Siemonsen, Damian Wenzel, Jan-Patrick Stellmann, Steffen Ringgaard, Bodil Ginnerup Pedersen, Egon Stenager, Thor Petersen, Kristian Vissing, Christoph Heesen, Ulrik Dalgas

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Multiple sclerosis (MS) is characterised by accelerated brain atrophy, which relates to disease progression. Previous research shows that progressive resistance training (PRT) can counteract brain atrophy in other populations.

OBJECTIVE: To evaluate the effects of PRT by magnetic resonance imaging (MRI) and clinical measures of disease progression in people with MS.

METHODS: This study was a 24-week randomised controlled cross-over trial, including a Training ( n = 18, 24 weeks of PRT followed by self-guided physical activity) and Waitlist group ( n = 17, 24 weeks of habitual lifestyle followed by PRT). Assessments included disability measures and MRI (lesion load, global brain volume, percentage brain volume change (PBVC) and cortical thickness).

RESULTS: While the MS Functional Composite score improved, Expanded Disability Status Scale, lesion load and global brain volumes did not differ between groups. PBVC tended to differ between groups and higher absolute cortical thickness values were observed in 19 of 74 investigated cortical regions after PRT. Observed changes were confirmed and reproduced when comparing relative cortical thickness changes between groups for four areas: anterior cingulate gyrus, temporal pole, orbital sulcus and inferior temporal sulcus.

CONCLUSION: PRT seem to induce an increase in cortical thickness, indicating that PRT have a neuroprotective or even neuroregenerative effect in relapsing-remitting MS.

OriginalsprogEngelsk
TidsskriftMultiple Sclerosis Journal
Vol/bind24
Udgave nummer10
Sider (fra-til)1356-1365
ISSN1352-4585
DOI
StatusUdgivet - 1. sep. 2018

Fingeraftryk

Relapsing-Remitting Multiple Sclerosis
Resistance Training
Gyrus Cinguli
Cross-Over Studies
Research
Population

Citer dette

Kjølhede, T., Siemonsen, S., Wenzel, D., Stellmann, J-P., Ringgaard, S., Pedersen, B. G., ... Dalgas, U. (2018). Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis? Multiple Sclerosis Journal, 24(10), 1356-1365. https://doi.org/10.1177/1352458517722645
Kjølhede, Tue ; Siemonsen, Susanne ; Wenzel, Damian ; Stellmann, Jan-Patrick ; Ringgaard, Steffen ; Pedersen, Bodil Ginnerup ; Stenager, Egon ; Petersen, Thor ; Vissing, Kristian ; Heesen, Christoph ; Dalgas, Ulrik. / Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?. I: Multiple Sclerosis Journal. 2018 ; Bind 24, Nr. 10. s. 1356-1365.
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abstract = "BACKGROUND: Multiple sclerosis (MS) is characterised by accelerated brain atrophy, which relates to disease progression. Previous research shows that progressive resistance training (PRT) can counteract brain atrophy in other populations.OBJECTIVE: To evaluate the effects of PRT by magnetic resonance imaging (MRI) and clinical measures of disease progression in people with MS.METHODS: This study was a 24-week randomised controlled cross-over trial, including a Training ( n = 18, 24 weeks of PRT followed by self-guided physical activity) and Waitlist group ( n = 17, 24 weeks of habitual lifestyle followed by PRT). Assessments included disability measures and MRI (lesion load, global brain volume, percentage brain volume change (PBVC) and cortical thickness).RESULTS: While the MS Functional Composite score improved, Expanded Disability Status Scale, lesion load and global brain volumes did not differ between groups. PBVC tended to differ between groups and higher absolute cortical thickness values were observed in 19 of 74 investigated cortical regions after PRT. Observed changes were confirmed and reproduced when comparing relative cortical thickness changes between groups for four areas: anterior cingulate gyrus, temporal pole, orbital sulcus and inferior temporal sulcus.CONCLUSION: PRT seem to induce an increase in cortical thickness, indicating that PRT have a neuroprotective or even neuroregenerative effect in relapsing-remitting MS.",
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Kjølhede, T, Siemonsen, S, Wenzel, D, Stellmann, J-P, Ringgaard, S, Pedersen, BG, Stenager, E, Petersen, T, Vissing, K, Heesen, C & Dalgas, U 2018, 'Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?', Multiple Sclerosis Journal, bind 24, nr. 10, s. 1356-1365. https://doi.org/10.1177/1352458517722645

Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis? / Kjølhede, Tue; Siemonsen, Susanne; Wenzel, Damian; Stellmann, Jan-Patrick; Ringgaard, Steffen; Pedersen, Bodil Ginnerup; Stenager, Egon; Petersen, Thor; Vissing, Kristian; Heesen, Christoph; Dalgas, Ulrik.

I: Multiple Sclerosis Journal, Bind 24, Nr. 10, 01.09.2018, s. 1356-1365.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?

AU - Kjølhede, Tue

AU - Siemonsen, Susanne

AU - Wenzel, Damian

AU - Stellmann, Jan-Patrick

AU - Ringgaard, Steffen

AU - Pedersen, Bodil Ginnerup

AU - Stenager, Egon

AU - Petersen, Thor

AU - Vissing, Kristian

AU - Heesen, Christoph

AU - Dalgas, Ulrik

PY - 2018/9/1

Y1 - 2018/9/1

N2 - BACKGROUND: Multiple sclerosis (MS) is characterised by accelerated brain atrophy, which relates to disease progression. Previous research shows that progressive resistance training (PRT) can counteract brain atrophy in other populations.OBJECTIVE: To evaluate the effects of PRT by magnetic resonance imaging (MRI) and clinical measures of disease progression in people with MS.METHODS: This study was a 24-week randomised controlled cross-over trial, including a Training ( n = 18, 24 weeks of PRT followed by self-guided physical activity) and Waitlist group ( n = 17, 24 weeks of habitual lifestyle followed by PRT). Assessments included disability measures and MRI (lesion load, global brain volume, percentage brain volume change (PBVC) and cortical thickness).RESULTS: While the MS Functional Composite score improved, Expanded Disability Status Scale, lesion load and global brain volumes did not differ between groups. PBVC tended to differ between groups and higher absolute cortical thickness values were observed in 19 of 74 investigated cortical regions after PRT. Observed changes were confirmed and reproduced when comparing relative cortical thickness changes between groups for four areas: anterior cingulate gyrus, temporal pole, orbital sulcus and inferior temporal sulcus.CONCLUSION: PRT seem to induce an increase in cortical thickness, indicating that PRT have a neuroprotective or even neuroregenerative effect in relapsing-remitting MS.

AB - BACKGROUND: Multiple sclerosis (MS) is characterised by accelerated brain atrophy, which relates to disease progression. Previous research shows that progressive resistance training (PRT) can counteract brain atrophy in other populations.OBJECTIVE: To evaluate the effects of PRT by magnetic resonance imaging (MRI) and clinical measures of disease progression in people with MS.METHODS: This study was a 24-week randomised controlled cross-over trial, including a Training ( n = 18, 24 weeks of PRT followed by self-guided physical activity) and Waitlist group ( n = 17, 24 weeks of habitual lifestyle followed by PRT). Assessments included disability measures and MRI (lesion load, global brain volume, percentage brain volume change (PBVC) and cortical thickness).RESULTS: While the MS Functional Composite score improved, Expanded Disability Status Scale, lesion load and global brain volumes did not differ between groups. PBVC tended to differ between groups and higher absolute cortical thickness values were observed in 19 of 74 investigated cortical regions after PRT. Observed changes were confirmed and reproduced when comparing relative cortical thickness changes between groups for four areas: anterior cingulate gyrus, temporal pole, orbital sulcus and inferior temporal sulcus.CONCLUSION: PRT seem to induce an increase in cortical thickness, indicating that PRT have a neuroprotective or even neuroregenerative effect in relapsing-remitting MS.

KW - MRI

KW - Multiple sclerosis

KW - brain volume

KW - cortical thickness

KW - rehabilitation

KW - resistance training

U2 - 10.1177/1352458517722645

DO - 10.1177/1352458517722645

M3 - Journal article

VL - 24

SP - 1356

EP - 1365

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

IS - 10

ER -

Kjølhede T, Siemonsen S, Wenzel D, Stellmann J-P, Ringgaard S, Pedersen BG et al. Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis? Multiple Sclerosis Journal. 2018 sep 1;24(10):1356-1365. https://doi.org/10.1177/1352458517722645