C-reactive Protein As a Predictor of Prognosis in Chronic Obstructive Pulmonary Disease

M Dahl, J Vestbo, P Lange, SE Bojesen, A Tybjaerg-Hansen, BG. Nordestgaard

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Rationale: Patients with chronic obstructive pulmonary disease (COPD) have an ongoing systemic inflammation, which can be assessed by measuring serum C-reactive protein (CRP).Objective: To determine whether increased serum CRP in individuals with airway obstruction predicts future hospitalization and death from COPD.Methods: We performed a cohort study with a median of 8-yr follow-up of 1,302 individuals with airway obstruction selected from the ongoing Copenhagen City Heart Study.Measurements and Main Results: We measured serum CRP at baseline, and recorded COPD admissions and deaths as outcomes. During follow-up, 185 (14%) individuals were hospitalized due to COPD and 83 (6%) died of COPD. Incidences of COPD hospitalization and COPD death were increased in individuals with baseline CRP > 3 mg/L versus ⩽ 3 mg/L (log rank: p < 0.001). After adjusting for sex, age, FEV1% predicted, tobacco consumption, and ischemic heart disease, the hazard ratios for hospitalization and death due to COPD were increased at 1.4 (95% confidence interval, 1.0–2.0) and 2.2 (1.2–3.9) in individuals with baseline CRP > 3 mg/L versus ⩽ 3 mg/L. After close matching for FEV1% predicted and adjusting for potential confounders, baseline CRP was, on average, increased by 1.2 mg/L (analysis of variance: p = 0.002) and 4.1 mg/L (p = 0.001) in those who were subsequently hospitalized or died of COPD, respectively. The absolute 10-yr risks for COPD hospitalization and death in individuals with CRP above 3 mg/L were 54 and 57%, respectively, among those older than 70 yr with a tobacco consumption above 15 g/d and an FEV1% predicted of less than 50.Conclusions: CRP is a strong and independent predictor of future COPD outcomes in individuals with airway obstruction.
OriginalsprogEngelsk
TidsskriftAmerican Journal of Respiratory and Critical Care Medicine
Vol/bind175
Udgave nummer3
Sider (fra-til)250-255
Antal sider6
ISSN1073-449X
DOI
StatusUdgivet - 1. feb. 2007
Udgivet eksterntJa

Fingeraftryk

Chronic Obstructive Pulmonary Disease
Airway Obstruction
Tobacco Use
Cohort Studies
Incidence

Citer dette

Dahl, M ; Vestbo, J ; Lange, P ; Bojesen, SE ; Tybjaerg-Hansen, A ; Nordestgaard, BG. / C-reactive Protein As a Predictor of Prognosis in Chronic Obstructive Pulmonary Disease. I: American Journal of Respiratory and Critical Care Medicine. 2007 ; Bind 175, Nr. 3. s. 250-255.
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title = "C-reactive Protein As a Predictor of Prognosis in Chronic Obstructive Pulmonary Disease",
abstract = "Rationale: Patients with chronic obstructive pulmonary disease (COPD) have an ongoing systemic inflammation, which can be assessed by measuring serum C-reactive protein (CRP).Objective: To determine whether increased serum CRP in individuals with airway obstruction predicts future hospitalization and death from COPD.Methods: We performed a cohort study with a median of 8-yr follow-up of 1,302 individuals with airway obstruction selected from the ongoing Copenhagen City Heart Study.Measurements and Main Results: We measured serum CRP at baseline, and recorded COPD admissions and deaths as outcomes. During follow-up, 185 (14{\%}) individuals were hospitalized due to COPD and 83 (6{\%}) died of COPD. Incidences of COPD hospitalization and COPD death were increased in individuals with baseline CRP > 3 mg/L versus ⩽ 3 mg/L (log rank: p < 0.001). After adjusting for sex, age, FEV1{\%} predicted, tobacco consumption, and ischemic heart disease, the hazard ratios for hospitalization and death due to COPD were increased at 1.4 (95{\%} confidence interval, 1.0–2.0) and 2.2 (1.2–3.9) in individuals with baseline CRP > 3 mg/L versus ⩽ 3 mg/L. After close matching for FEV1{\%} predicted and adjusting for potential confounders, baseline CRP was, on average, increased by 1.2 mg/L (analysis of variance: p = 0.002) and 4.1 mg/L (p = 0.001) in those who were subsequently hospitalized or died of COPD, respectively. The absolute 10-yr risks for COPD hospitalization and death in individuals with CRP above 3 mg/L were 54 and 57{\%}, respectively, among those older than 70 yr with a tobacco consumption above 15 g/d and an FEV1{\%} predicted of less than 50.Conclusions: CRP is a strong and independent predictor of future COPD outcomes in individuals with airway obstruction.",
author = "M Dahl and J Vestbo and P Lange and SE Bojesen and A Tybjaerg-Hansen and BG. Nordestgaard",
year = "2007",
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doi = "10.1164/rccm.200605-713OC",
language = "English",
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C-reactive Protein As a Predictor of Prognosis in Chronic Obstructive Pulmonary Disease. / Dahl, M; Vestbo, J; Lange, P; Bojesen, SE; Tybjaerg-Hansen, A; Nordestgaard, BG.

I: American Journal of Respiratory and Critical Care Medicine, Bind 175, Nr. 3, 01.02.2007, s. 250-255.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - C-reactive Protein As a Predictor of Prognosis in Chronic Obstructive Pulmonary Disease

AU - Dahl, M

AU - Vestbo, J

AU - Lange, P

AU - Bojesen, SE

AU - Tybjaerg-Hansen, A

AU - Nordestgaard, BG.

PY - 2007/2/1

Y1 - 2007/2/1

N2 - Rationale: Patients with chronic obstructive pulmonary disease (COPD) have an ongoing systemic inflammation, which can be assessed by measuring serum C-reactive protein (CRP).Objective: To determine whether increased serum CRP in individuals with airway obstruction predicts future hospitalization and death from COPD.Methods: We performed a cohort study with a median of 8-yr follow-up of 1,302 individuals with airway obstruction selected from the ongoing Copenhagen City Heart Study.Measurements and Main Results: We measured serum CRP at baseline, and recorded COPD admissions and deaths as outcomes. During follow-up, 185 (14%) individuals were hospitalized due to COPD and 83 (6%) died of COPD. Incidences of COPD hospitalization and COPD death were increased in individuals with baseline CRP > 3 mg/L versus ⩽ 3 mg/L (log rank: p < 0.001). After adjusting for sex, age, FEV1% predicted, tobacco consumption, and ischemic heart disease, the hazard ratios for hospitalization and death due to COPD were increased at 1.4 (95% confidence interval, 1.0–2.0) and 2.2 (1.2–3.9) in individuals with baseline CRP > 3 mg/L versus ⩽ 3 mg/L. After close matching for FEV1% predicted and adjusting for potential confounders, baseline CRP was, on average, increased by 1.2 mg/L (analysis of variance: p = 0.002) and 4.1 mg/L (p = 0.001) in those who were subsequently hospitalized or died of COPD, respectively. The absolute 10-yr risks for COPD hospitalization and death in individuals with CRP above 3 mg/L were 54 and 57%, respectively, among those older than 70 yr with a tobacco consumption above 15 g/d and an FEV1% predicted of less than 50.Conclusions: CRP is a strong and independent predictor of future COPD outcomes in individuals with airway obstruction.

AB - Rationale: Patients with chronic obstructive pulmonary disease (COPD) have an ongoing systemic inflammation, which can be assessed by measuring serum C-reactive protein (CRP).Objective: To determine whether increased serum CRP in individuals with airway obstruction predicts future hospitalization and death from COPD.Methods: We performed a cohort study with a median of 8-yr follow-up of 1,302 individuals with airway obstruction selected from the ongoing Copenhagen City Heart Study.Measurements and Main Results: We measured serum CRP at baseline, and recorded COPD admissions and deaths as outcomes. During follow-up, 185 (14%) individuals were hospitalized due to COPD and 83 (6%) died of COPD. Incidences of COPD hospitalization and COPD death were increased in individuals with baseline CRP > 3 mg/L versus ⩽ 3 mg/L (log rank: p < 0.001). After adjusting for sex, age, FEV1% predicted, tobacco consumption, and ischemic heart disease, the hazard ratios for hospitalization and death due to COPD were increased at 1.4 (95% confidence interval, 1.0–2.0) and 2.2 (1.2–3.9) in individuals with baseline CRP > 3 mg/L versus ⩽ 3 mg/L. After close matching for FEV1% predicted and adjusting for potential confounders, baseline CRP was, on average, increased by 1.2 mg/L (analysis of variance: p = 0.002) and 4.1 mg/L (p = 0.001) in those who were subsequently hospitalized or died of COPD, respectively. The absolute 10-yr risks for COPD hospitalization and death in individuals with CRP above 3 mg/L were 54 and 57%, respectively, among those older than 70 yr with a tobacco consumption above 15 g/d and an FEV1% predicted of less than 50.Conclusions: CRP is a strong and independent predictor of future COPD outcomes in individuals with airway obstruction.

U2 - 10.1164/rccm.200605-713OC

DO - 10.1164/rccm.200605-713OC

M3 - Journal article

VL - 175

SP - 250

EP - 255

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 3

ER -