Breast conserving treatment in Denmark, 1989-1998. A nationwide population-based study of the Danish Breast Cancer Co-operative Group

Marianne Ewertz, Mette Moe Kempel, Maria Düring, Maj-Britt Jensen, Michael Andersson, Peer Christiansen, Niels Kroman, Birgitte Bruun Rasmussen, Marie Overgaard

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2008-null
OriginalsprogEngelsk
TidsskriftActa Oncologica
Vol/bind47
Udgave nummer4
Sider (fra-til)682-690
Antal sider8
ISSN0284-186X
DOI
StatusUdgivet - 1. jan. 2008

Fingeraftryk

Denmark
Segmental Mastectomy
Population
Adjuvant Radiotherapy
Randomized Controlled Trials
Databases
Incidence
Neoplasms

Citer dette

Ewertz, Marianne ; Kempel, Mette Moe ; Düring, Maria ; Jensen, Maj-Britt ; Andersson, Michael ; Christiansen, Peer ; Kroman, Niels ; Rasmussen, Birgitte Bruun ; Overgaard, Marie. / Breast conserving treatment in Denmark, 1989-1998. A nationwide population-based study of the Danish Breast Cancer Co-operative Group. I: Acta Oncologica. 2008 ; Bind 47, Nr. 4. s. 682-690.
@article{089f0980455511dd9fbe000ea68e967b,
title = "Breast conserving treatment in Denmark, 1989-1998. A nationwide population-based study of the Danish Breast Cancer Co-operative Group",
abstract = "BACKGROUND: Randomised studies have shown that breast conserving surgery followed by radiotherapy is associated with a prognosis similar to mastectomy alone. This formed the basis for recommending breast conserving surgery combined with radiotherapy as a standard treatment for suited breast cancer patients in Denmark. PATIENTS AND METHODS: To evaluate the results of this treatment, we performed a nationwide population-based follow-up study of patients aged less than 75 years treated in Denmark from 1989 to 1998 based on the database of Danish Breast Cancer Cooperative Group. RESULTS: At 15 years of follow-up, the Kaplan-Meier estimate of overall survival was 69{\%} among 3 758 patients who received the recommended treatment. Within the first 10 years of follow-up, the cumulative incidences of loco-regional recurrences, distant metastases or other malignant disease, or death as a first event were 9.0, 19.9, and 6.0{\%} respectively, when analysed in a competing risk setting. The risk of loco-regional recurrences was significantly decreased in patients aged 50 years or more and increased with increasing tumour size. There was a pronounced beneficial effect of adjuvant radiotherapy with those not receiving radiotherapy having a hazard ratio of 3.52 (95{\%} CI 2.21-5.61). The effect of resection margins was significant for loco-regional recurrences only in node negative patients. CONCLUSION: In conclusion, the present study shows that results similar to those from randomised clinical trials can be obtained when breast conserving treatment is applied as a standard treatment in an entire population.",
keywords = "Aged, Breast Neoplasms, Denmark, Female, Humans, Mastectomy, Segmental, Middle Aged, Neoplasm Recurrence, Local, Radiotherapy, Adjuvant, Randomized Controlled Trials as Topic, Risk Factors, Survival Rate",
author = "Marianne Ewertz and Kempel, {Mette Moe} and Maria D{\"u}ring and Maj-Britt Jensen and Michael Andersson and Peer Christiansen and Niels Kroman and Rasmussen, {Birgitte Bruun} and Marie Overgaard",
year = "2008",
month = "1",
day = "1",
doi = "10.1080/02841860802032769",
language = "English",
volume = "47",
pages = "682--690",
journal = "Acta Oncologica",
issn = "0284-186X",
publisher = "Taylor & Francis",
number = "4",

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Ewertz, M, Kempel, MM, Düring, M, Jensen, M-B, Andersson, M, Christiansen, P, Kroman, N, Rasmussen, BB & Overgaard, M 2008, 'Breast conserving treatment in Denmark, 1989-1998. A nationwide population-based study of the Danish Breast Cancer Co-operative Group', Acta Oncologica, bind 47, nr. 4, s. 682-690. https://doi.org/10.1080/02841860802032769

Breast conserving treatment in Denmark, 1989-1998. A nationwide population-based study of the Danish Breast Cancer Co-operative Group. / Ewertz, Marianne; Kempel, Mette Moe; Düring, Maria; Jensen, Maj-Britt; Andersson, Michael; Christiansen, Peer; Kroman, Niels; Rasmussen, Birgitte Bruun; Overgaard, Marie.

I: Acta Oncologica, Bind 47, Nr. 4, 01.01.2008, s. 682-690.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Breast conserving treatment in Denmark, 1989-1998. A nationwide population-based study of the Danish Breast Cancer Co-operative Group

AU - Ewertz, Marianne

AU - Kempel, Mette Moe

AU - Düring, Maria

AU - Jensen, Maj-Britt

AU - Andersson, Michael

AU - Christiansen, Peer

AU - Kroman, Niels

AU - Rasmussen, Birgitte Bruun

AU - Overgaard, Marie

PY - 2008/1/1

Y1 - 2008/1/1

N2 - BACKGROUND: Randomised studies have shown that breast conserving surgery followed by radiotherapy is associated with a prognosis similar to mastectomy alone. This formed the basis for recommending breast conserving surgery combined with radiotherapy as a standard treatment for suited breast cancer patients in Denmark. PATIENTS AND METHODS: To evaluate the results of this treatment, we performed a nationwide population-based follow-up study of patients aged less than 75 years treated in Denmark from 1989 to 1998 based on the database of Danish Breast Cancer Cooperative Group. RESULTS: At 15 years of follow-up, the Kaplan-Meier estimate of overall survival was 69% among 3 758 patients who received the recommended treatment. Within the first 10 years of follow-up, the cumulative incidences of loco-regional recurrences, distant metastases or other malignant disease, or death as a first event were 9.0, 19.9, and 6.0% respectively, when analysed in a competing risk setting. The risk of loco-regional recurrences was significantly decreased in patients aged 50 years or more and increased with increasing tumour size. There was a pronounced beneficial effect of adjuvant radiotherapy with those not receiving radiotherapy having a hazard ratio of 3.52 (95% CI 2.21-5.61). The effect of resection margins was significant for loco-regional recurrences only in node negative patients. CONCLUSION: In conclusion, the present study shows that results similar to those from randomised clinical trials can be obtained when breast conserving treatment is applied as a standard treatment in an entire population.

AB - BACKGROUND: Randomised studies have shown that breast conserving surgery followed by radiotherapy is associated with a prognosis similar to mastectomy alone. This formed the basis for recommending breast conserving surgery combined with radiotherapy as a standard treatment for suited breast cancer patients in Denmark. PATIENTS AND METHODS: To evaluate the results of this treatment, we performed a nationwide population-based follow-up study of patients aged less than 75 years treated in Denmark from 1989 to 1998 based on the database of Danish Breast Cancer Cooperative Group. RESULTS: At 15 years of follow-up, the Kaplan-Meier estimate of overall survival was 69% among 3 758 patients who received the recommended treatment. Within the first 10 years of follow-up, the cumulative incidences of loco-regional recurrences, distant metastases or other malignant disease, or death as a first event were 9.0, 19.9, and 6.0% respectively, when analysed in a competing risk setting. The risk of loco-regional recurrences was significantly decreased in patients aged 50 years or more and increased with increasing tumour size. There was a pronounced beneficial effect of adjuvant radiotherapy with those not receiving radiotherapy having a hazard ratio of 3.52 (95% CI 2.21-5.61). The effect of resection margins was significant for loco-regional recurrences only in node negative patients. CONCLUSION: In conclusion, the present study shows that results similar to those from randomised clinical trials can be obtained when breast conserving treatment is applied as a standard treatment in an entire population.

KW - Aged

KW - Breast Neoplasms

KW - Denmark

KW - Female

KW - Humans

KW - Mastectomy, Segmental

KW - Middle Aged

KW - Neoplasm Recurrence, Local

KW - Radiotherapy, Adjuvant

KW - Randomized Controlled Trials as Topic

KW - Risk Factors

KW - Survival Rate

U2 - 10.1080/02841860802032769

DO - 10.1080/02841860802032769

M3 - Journal article

VL - 47

SP - 682

EP - 690

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 4

ER -