Bovine Colostrum to Children With Short Bowel Syndrome: A Randomized, Double-Blind, Crossover Pilot Study

Bidragets oversatte titel: Bovine Colostrum to Children With Short Bowel Syndrome: A Randomized, Double-Blind, Crossover Pilot Study

L. Aunsholt, Palle Bekker Jeppesen, P. Lund, P. T. Sangild, I. B. R. Ifaoui, N. Qvist, S. Husby

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background: Management of short bowel syndrome (SBS) aims to achieve intestinal autonomy to prevent fluid, electrolyte, and nutrient deficiencies and maintain adequate development. Remnant intestinal adaptation is required to obtain autonomy. In the newborn pig, colostrum has been shown to support intestinal development and hence adaptive processes. Aim: The efficacy of bovine colostrum to improve intestinal function in children with SBS was evaluated by metabolic balance studies. Materials and Methods: Nine children with SBS were included in a randomized, double-blind, crossover study. Twenty percent of enteral fluid intake was replaced with bovine colostrum or a mixed milk diet for 4 weeks, separated by a 4-week washout period. Intestinal absorption of energy and wet weight was used to assess intestinal function and the efficacy of colostrum. Results: Colostrum did not improve energy or wet weight absorption compared with the mixed milk diet (P = 1.00 and P = .93, respectively). Growth as measured by weight and knemometry did not differ between diets (P = .93 and P = .28). In these patients,
OriginalsprogEngelsk
TidsskriftJournal of Parenteral and Enteral Nutrition
Vol/bind38
Udgave nummer1
Sider (fra-til)99-106
ISSN0148-6071
DOI
StatusUdgivet - 2014

Citer dette

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title = "Bovine Colostrum to Children With Short Bowel Syndrome: A Randomized, Double-Blind, Crossover Pilot Study",
abstract = "Background: Management of short bowel syndrome (SBS) aims to achieve intestinal autonomy to prevent fluid, electrolyte, and nutrient deficiencies and maintain adequate development. Remnant intestinal adaptation is required to obtain autonomy. In the newborn pig, colostrum has been shown to support intestinal development and hence adaptive processes. Aim: The efficacy of bovine colostrum to improve intestinal function in children with SBS was evaluated by metabolic balance studies. Materials and Methods: Nine children with SBS were included in a randomized, double-blind, crossover study. Twenty percent of enteral fluid intake was replaced with bovine colostrum or a mixed milk diet for 4 weeks, separated by a 4-week washout period. Intestinal absorption of energy and wet weight was used to assess intestinal function and the efficacy of colostrum. Results: Colostrum did not improve energy or wet weight absorption compared with the mixed milk diet (P = 1.00 and P = .93, respectively). Growth as measured by weight and knemometry did not differ between diets (P = .93 and P = .28). In these patients,",
keywords = "children short bowel syndrome colostrum energy absorption GROWTH-FACTOR-I INTESTINAL FAILURE NECROTIZING ENTEROCOLITIS PRETERM PIGS EXERCISE PERFORMANCE NEONATAL PIGLETS BODY-COMPOSITION CONTROLLED-TRIAL CYSTIC-FIBROSIS CLINICAL-TRIAL",
author = "L. Aunsholt and Jeppesen, {Palle Bekker} and P. Lund and Sangild, {P. T.} and Ifaoui, {I. B. R.} and N. Qvist and S. Husby",
note = "ISI Document Delivery No.: 285AV Times Cited: 3 Cited Reference Count: 47 Aunsholt, Lise Jeppesen, Palle Bekker Lund, Pernille Sangild, Per Torp Ifaoui, Inge Botker Rasmussen Qvist, Niels Husby, Steffen Novo Research Foundation, Copenhagen, Denmark; A. J. Andersen and Wife Foundation, Odense, Denmark; Danish Strategic Research Council for Health, Food and Welfare Supported by The Novo Research Foundation, Copenhagen, Denmark; A. J. Andersen and Wife Foundation, Odense, Denmark; and the Danish Strategic Research Council for Health, Food and Welfare. 3 SAGE PUBLICATIONS INC THOUSAND OAKS JPEN-PARENTER ENTER",
year = "2014",
doi = "10.1177/0148607112469630",
language = "English",
volume = "38",
pages = "99--106",
journal = "Journal of Parenteral and Enteral Nutrition",
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publisher = "SAGE Publications",
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Bovine Colostrum to Children With Short Bowel Syndrome: A Randomized, Double-Blind, Crossover Pilot Study. / Aunsholt, L.; Jeppesen, Palle Bekker; Lund, P.; Sangild, P. T.; Ifaoui, I. B. R.; Qvist, N.; Husby, S.

I: Journal of Parenteral and Enteral Nutrition, Bind 38, Nr. 1, 2014, s. 99-106.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Bovine Colostrum to Children With Short Bowel Syndrome: A Randomized, Double-Blind, Crossover Pilot Study

AU - Aunsholt, L.

AU - Jeppesen, Palle Bekker

AU - Lund, P.

AU - Sangild, P. T.

AU - Ifaoui, I. B. R.

AU - Qvist, N.

AU - Husby, S.

N1 - ISI Document Delivery No.: 285AV Times Cited: 3 Cited Reference Count: 47 Aunsholt, Lise Jeppesen, Palle Bekker Lund, Pernille Sangild, Per Torp Ifaoui, Inge Botker Rasmussen Qvist, Niels Husby, Steffen Novo Research Foundation, Copenhagen, Denmark; A. J. Andersen and Wife Foundation, Odense, Denmark; Danish Strategic Research Council for Health, Food and Welfare Supported by The Novo Research Foundation, Copenhagen, Denmark; A. J. Andersen and Wife Foundation, Odense, Denmark; and the Danish Strategic Research Council for Health, Food and Welfare. 3 SAGE PUBLICATIONS INC THOUSAND OAKS JPEN-PARENTER ENTER

PY - 2014

Y1 - 2014

N2 - Background: Management of short bowel syndrome (SBS) aims to achieve intestinal autonomy to prevent fluid, electrolyte, and nutrient deficiencies and maintain adequate development. Remnant intestinal adaptation is required to obtain autonomy. In the newborn pig, colostrum has been shown to support intestinal development and hence adaptive processes. Aim: The efficacy of bovine colostrum to improve intestinal function in children with SBS was evaluated by metabolic balance studies. Materials and Methods: Nine children with SBS were included in a randomized, double-blind, crossover study. Twenty percent of enteral fluid intake was replaced with bovine colostrum or a mixed milk diet for 4 weeks, separated by a 4-week washout period. Intestinal absorption of energy and wet weight was used to assess intestinal function and the efficacy of colostrum. Results: Colostrum did not improve energy or wet weight absorption compared with the mixed milk diet (P = 1.00 and P = .93, respectively). Growth as measured by weight and knemometry did not differ between diets (P = .93 and P = .28). In these patients,

AB - Background: Management of short bowel syndrome (SBS) aims to achieve intestinal autonomy to prevent fluid, electrolyte, and nutrient deficiencies and maintain adequate development. Remnant intestinal adaptation is required to obtain autonomy. In the newborn pig, colostrum has been shown to support intestinal development and hence adaptive processes. Aim: The efficacy of bovine colostrum to improve intestinal function in children with SBS was evaluated by metabolic balance studies. Materials and Methods: Nine children with SBS were included in a randomized, double-blind, crossover study. Twenty percent of enteral fluid intake was replaced with bovine colostrum or a mixed milk diet for 4 weeks, separated by a 4-week washout period. Intestinal absorption of energy and wet weight was used to assess intestinal function and the efficacy of colostrum. Results: Colostrum did not improve energy or wet weight absorption compared with the mixed milk diet (P = 1.00 and P = .93, respectively). Growth as measured by weight and knemometry did not differ between diets (P = .93 and P = .28). In these patients,

KW - children short bowel syndrome colostrum energy absorption GROWTH-FACTOR-I INTESTINAL FAILURE NECROTIZING ENTEROCOLITIS PRETERM PIGS EXERCISE PERFORMANCE NEONATAL PIGLETS BODY-COMPOSITION CONTROLLED-TRIAL CYSTIC-FIBROSIS CLINICAL-TRIAL

U2 - 10.1177/0148607112469630

DO - 10.1177/0148607112469630

M3 - Journal article

VL - 38

SP - 99

EP - 106

JO - Journal of Parenteral and Enteral Nutrition

JF - Journal of Parenteral and Enteral Nutrition

SN - 0148-6071

IS - 1

ER -