Bone mineral density is preserved in men with idiopathic infertility

L. Antonio, L. Priskorn, L. Nordkap, A. K. Bang, T. K. Jensen, N. E. Skakkebæk, J. H. Petersen, D. Vanderschueren, N. Jørgensen*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background: Lower semen quality is associated with increased mortality and morbidity, which may include osteoporosis. Objective: To assess whether infertile men have a lower bone mineral density (BMD) compared with fertile men at the time of fertility workup. Methods: A total of 146 men from infertile couples with unexplained impaired semen quality, characterized by sperm concentration < 20 million/mL, progressive motility < 50% or < 12% morphologically normal spermatozoa. Men with infertility due to a genetic etiology or a condition that could cause testicular damage were excluded. A total of 271 men from couples with an ongoing naturally conceived pregnancy served as a control group. Lumbar, femoral, and total body BMD were measured by dual X-ray absorptiometry. Results: Infertile men had similar BMD compared with fertile men (Beta coefficient (g/cm2) and 95% confidence interval for the difference between the two groups: −0.02 (−0.05; 0.01) for lumbar BMD, −0.02 (−0.05; 0.01) for femoral neck BMD, −0.01 (−0.04; 0.02) for total femur BMD, and −0.01 (−0.03; 0.01) for total body BMD). Semen parameters were not associated with BMD measurements. Furthermore, BMD did not differ between infertile men with the lowest semen quality vs. infertile men with better semen quality nor between infertile men with low testosterone vs. fertile men with normal testosterone levels. Conclusion: Bone mineral density is preserved in men with unexplained infertility at the time of fertility workup.

OriginalsprogEngelsk
TidsskriftAndrology
ISSN0196-3635
DOI
StatusUdgivet - 2019

Fingeraftryk

Bone Density
Infertility
Femur Neck
Photon Absorptiometry
Semen
Confidence Intervals
Control Groups

Citer dette

Antonio, L., Priskorn, L., Nordkap, L., Bang, A. K., Jensen, T. K., Skakkebæk, N. E., ... Jørgensen, N. (2019). Bone mineral density is preserved in men with idiopathic infertility. Andrology. https://doi.org/10.1111/andr.12688
Antonio, L. ; Priskorn, L. ; Nordkap, L. ; Bang, A. K. ; Jensen, T. K. ; Skakkebæk, N. E. ; Petersen, J. H. ; Vanderschueren, D. ; Jørgensen, N. / Bone mineral density is preserved in men with idiopathic infertility. I: Andrology. 2019.
@article{b496e650c5a44d15bb0d76a318d43a8e,
title = "Bone mineral density is preserved in men with idiopathic infertility",
abstract = "Background: Lower semen quality is associated with increased mortality and morbidity, which may include osteoporosis. Objective: To assess whether infertile men have a lower bone mineral density (BMD) compared with fertile men at the time of fertility workup. Methods: A total of 146 men from infertile couples with unexplained impaired semen quality, characterized by sperm concentration < 20 million/mL, progressive motility < 50{\%} or < 12{\%} morphologically normal spermatozoa. Men with infertility due to a genetic etiology or a condition that could cause testicular damage were excluded. A total of 271 men from couples with an ongoing naturally conceived pregnancy served as a control group. Lumbar, femoral, and total body BMD were measured by dual X-ray absorptiometry. Results: Infertile men had similar BMD compared with fertile men (Beta coefficient (g/cm2) and 95{\%} confidence interval for the difference between the two groups: −0.02 (−0.05; 0.01) for lumbar BMD, −0.02 (−0.05; 0.01) for femoral neck BMD, −0.01 (−0.04; 0.02) for total femur BMD, and −0.01 (−0.03; 0.01) for total body BMD). Semen parameters were not associated with BMD measurements. Furthermore, BMD did not differ between infertile men with the lowest semen quality vs. infertile men with better semen quality nor between infertile men with low testosterone vs. fertile men with normal testosterone levels. Conclusion: Bone mineral density is preserved in men with unexplained infertility at the time of fertility workup.",
keywords = "bone mineral density, male infertility, reproductive hormones, semen quality",
author = "L. Antonio and L. Priskorn and L. Nordkap and Bang, {A. K.} and Jensen, {T. K.} and Skakkeb{\ae}k, {N. E.} and Petersen, {J. H.} and D. Vanderschueren and N. J{\o}rgensen",
year = "2019",
doi = "10.1111/andr.12688",
language = "English",
journal = "Andrology",
issn = "2047-2919",
publisher = "Wiley-Blackwell",

}

Antonio, L, Priskorn, L, Nordkap, L, Bang, AK, Jensen, TK, Skakkebæk, NE, Petersen, JH, Vanderschueren, D & Jørgensen, N 2019, 'Bone mineral density is preserved in men with idiopathic infertility', Andrology. https://doi.org/10.1111/andr.12688

Bone mineral density is preserved in men with idiopathic infertility. / Antonio, L.; Priskorn, L.; Nordkap, L.; Bang, A. K.; Jensen, T. K.; Skakkebæk, N. E.; Petersen, J. H.; Vanderschueren, D.; Jørgensen, N.

I: Andrology, 2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Bone mineral density is preserved in men with idiopathic infertility

AU - Antonio, L.

AU - Priskorn, L.

AU - Nordkap, L.

AU - Bang, A. K.

AU - Jensen, T. K.

AU - Skakkebæk, N. E.

AU - Petersen, J. H.

AU - Vanderschueren, D.

AU - Jørgensen, N.

PY - 2019

Y1 - 2019

N2 - Background: Lower semen quality is associated with increased mortality and morbidity, which may include osteoporosis. Objective: To assess whether infertile men have a lower bone mineral density (BMD) compared with fertile men at the time of fertility workup. Methods: A total of 146 men from infertile couples with unexplained impaired semen quality, characterized by sperm concentration < 20 million/mL, progressive motility < 50% or < 12% morphologically normal spermatozoa. Men with infertility due to a genetic etiology or a condition that could cause testicular damage were excluded. A total of 271 men from couples with an ongoing naturally conceived pregnancy served as a control group. Lumbar, femoral, and total body BMD were measured by dual X-ray absorptiometry. Results: Infertile men had similar BMD compared with fertile men (Beta coefficient (g/cm2) and 95% confidence interval for the difference between the two groups: −0.02 (−0.05; 0.01) for lumbar BMD, −0.02 (−0.05; 0.01) for femoral neck BMD, −0.01 (−0.04; 0.02) for total femur BMD, and −0.01 (−0.03; 0.01) for total body BMD). Semen parameters were not associated with BMD measurements. Furthermore, BMD did not differ between infertile men with the lowest semen quality vs. infertile men with better semen quality nor between infertile men with low testosterone vs. fertile men with normal testosterone levels. Conclusion: Bone mineral density is preserved in men with unexplained infertility at the time of fertility workup.

AB - Background: Lower semen quality is associated with increased mortality and morbidity, which may include osteoporosis. Objective: To assess whether infertile men have a lower bone mineral density (BMD) compared with fertile men at the time of fertility workup. Methods: A total of 146 men from infertile couples with unexplained impaired semen quality, characterized by sperm concentration < 20 million/mL, progressive motility < 50% or < 12% morphologically normal spermatozoa. Men with infertility due to a genetic etiology or a condition that could cause testicular damage were excluded. A total of 271 men from couples with an ongoing naturally conceived pregnancy served as a control group. Lumbar, femoral, and total body BMD were measured by dual X-ray absorptiometry. Results: Infertile men had similar BMD compared with fertile men (Beta coefficient (g/cm2) and 95% confidence interval for the difference between the two groups: −0.02 (−0.05; 0.01) for lumbar BMD, −0.02 (−0.05; 0.01) for femoral neck BMD, −0.01 (−0.04; 0.02) for total femur BMD, and −0.01 (−0.03; 0.01) for total body BMD). Semen parameters were not associated with BMD measurements. Furthermore, BMD did not differ between infertile men with the lowest semen quality vs. infertile men with better semen quality nor between infertile men with low testosterone vs. fertile men with normal testosterone levels. Conclusion: Bone mineral density is preserved in men with unexplained infertility at the time of fertility workup.

KW - bone mineral density

KW - male infertility

KW - reproductive hormones

KW - semen quality

U2 - 10.1111/andr.12688

DO - 10.1111/andr.12688

M3 - Journal article

JO - Andrology

JF - Andrology

SN - 2047-2919

ER -