Body mass index trajectories in childhood and incidence rates of type 2 diabetes and coronary heart disease in adulthood: A cohort study

Kim Blond; Dorte Vistisen; Julie Aarestrup; Lise G. Bjerregaard; Mohammed T. Hudda; Anne Tjønneland; Kristine H. Allin; Marit E. Jørgensen; Britt W. Jensen; Jennifer L. Baker

doi:10.1016/j.diabres.2022.110055

Body mass index trajectories in childhood and incidence rates of type 2 diabetes and coronary heart disease in adulthood: A cohort study

Kim Blond, Dorte Vistisen, Julie Aarestrup, Lise G. Bjerregaard, Mohammed T. Hudda, Anne Tjønneland, Kristine H. Allin, Marit E. Jørgensen, Britt W. Jensen, Jennifer L. Baker^*

^*Kontaktforfatter

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Aims: We examined associations between five body mass index (BMI) trajectories from ages 6–15 years and register-based adult-onset type 2 diabetes mellitus (T2D) and coronary heart disease (CHD) with and without adjustment for adult BMI. Methods: Child and adult BMI came from two Danish cohorts and 13,205 and 13,438 individuals were included in T2D and CHD analyses, respectively. Trajectories were estimated by latent class modelling. Incidence rate ratios (IRRs) were estimated with Poisson regression. Results: In models without adult BMI, compared to the lowest trajectory, among men the T2D IRRs were 0.92 (95 %CI:0.77–1.09) for the second lowest trajectory and 1.51 (95 %CI:0.71–3.20) for the highest trajectory. The corresponding IRRs in women were 0.92 (95 %CI:0.74–1.16) and 3.58 (95 %CI:2.30–5.57). In models including adult BMI, compared to the lowest trajectory, T2D IRRs in men were 0.57 (95 %CI:0.47–0.68) for the second lowest trajectory and 0.26 (95 %CI:0.12–0.56) for the highest trajectory. The corresponding IRRs in women were 0.60 (95 %CI:0.48–0.75) and 0.59 (95 %CI:0.36–0.96). The associations were similar in direction, but not statistically significant, for CHD. Conclusions: Incidence rates of adult-onset T2D were greater for a high child BMI trajectory than a low child BMI trajectory, but not in models that included adult BMI.

Originalsprog	Engelsk
Artikelnummer	110055
Tidsskrift	Diabetes Research and Clinical Practice
Vol/bind	191
Antal sider	6
ISSN	0168-8227
DOI	https://doi.org/10.1016/j.diabres.2022.110055
Status	Udgivet - sep. 2022

Bibliografisk note

Funding Information:
This project received funding from The Novo Nordisk Foundation NNF17OC0028338. The funders had no role in the study design, data collection, data analyses, interpretation of results, preparation of the manuscript or the publication process.

Funding Information:
KB, JA, LGB, MTH, JLB, AT, BWJ and KHA report no conflicts of interest. DV reports shares in Novo Nordisk A/S and has received research grants from Bayer A/S, Sanofi Aventis, Novo Nordisk A/S and Boehringer Ingelheim. MEJ has received research grants from Astra Zeneca, AMGEN, Sanofi Aventis, Novo Nordisk A/S and Boehringer Ingelheim.

Dokumenter og links

10.1016/j.diabres.2022.110055Licens: CC BY

Open access versionForlagets udgivne version, 692 KBLicens: CC BY

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

Blond, K., Vistisen, D., Aarestrup, J., Bjerregaard, L. G., Hudda, M. T., Tjønneland, A., Allin, K. H., Jørgensen, M. E., Jensen, B. W., & Baker, J. L. (2022). Body mass index trajectories in childhood and incidence rates of type 2 diabetes and coronary heart disease in adulthood: A cohort study. Diabetes Research and Clinical Practice, 191, Artikel 110055. https://doi.org/10.1016/j.diabres.2022.110055

@article{2395679b79624876a37d104122f573e1,

title = "Body mass index trajectories in childhood and incidence rates of type 2 diabetes and coronary heart disease in adulthood: A cohort study",

abstract = "Aims: We examined associations between five body mass index (BMI) trajectories from ages 6–15 years and register-based adult-onset type 2 diabetes mellitus (T2D) and coronary heart disease (CHD) with and without adjustment for adult BMI. Methods: Child and adult BMI came from two Danish cohorts and 13,205 and 13,438 individuals were included in T2D and CHD analyses, respectively. Trajectories were estimated by latent class modelling. Incidence rate ratios (IRRs) were estimated with Poisson regression. Results: In models without adult BMI, compared to the lowest trajectory, among men the T2D IRRs were 0.92 (95 %CI:0.77–1.09) for the second lowest trajectory and 1.51 (95 %CI:0.71–3.20) for the highest trajectory. The corresponding IRRs in women were 0.92 (95 %CI:0.74–1.16) and 3.58 (95 %CI:2.30–5.57). In models including adult BMI, compared to the lowest trajectory, T2D IRRs in men were 0.57 (95 %CI:0.47–0.68) for the second lowest trajectory and 0.26 (95 %CI:0.12–0.56) for the highest trajectory. The corresponding IRRs in women were 0.60 (95 %CI:0.48–0.75) and 0.59 (95 %CI:0.36–0.96). The associations were similar in direction, but not statistically significant, for CHD. Conclusions: Incidence rates of adult-onset T2D were greater for a high child BMI trajectory than a low child BMI trajectory, but not in models that included adult BMI.",

keywords = "Body mass index, Cardiovascular diseases, Diabetes mellitus, Type 2",

author = "Kim Blond and Dorte Vistisen and Julie Aarestrup and Bjerregaard, {Lise G.} and Hudda, {Mohammed T.} and Anne Tj{\o}nneland and Allin, {Kristine H.} and J{\o}rgensen, {Marit E.} and Jensen, {Britt W.} and Baker, {Jennifer L.}",

note = "Funding Information: This project received funding from The Novo Nordisk Foundation NNF17OC0028338. The funders had no role in the study design, data collection, data analyses, interpretation of results, preparation of the manuscript or the publication process. Funding Information: KB, JA, LGB, MTH, JLB, AT, BWJ and KHA report no conflicts of interest. DV reports shares in Novo Nordisk A/S and has received research grants from Bayer A/S, Sanofi Aventis, Novo Nordisk A/S and Boehringer Ingelheim. MEJ has received research grants from Astra Zeneca, AMGEN, Sanofi Aventis, Novo Nordisk A/S and Boehringer Ingelheim. ",

year = "2022",

month = sep,

doi = "10.1016/j.diabres.2022.110055",

language = "English",

volume = "191",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier",

}

Blond, K, Vistisen, D, Aarestrup, J, Bjerregaard, LG, Hudda, MT, Tjønneland, A, Allin, KH, Jørgensen, ME, Jensen, BW & Baker, JL 2022, 'Body mass index trajectories in childhood and incidence rates of type 2 diabetes and coronary heart disease in adulthood: A cohort study', Diabetes Research and Clinical Practice, bind 191, 110055. https://doi.org/10.1016/j.diabres.2022.110055

TY - JOUR

T1 - Body mass index trajectories in childhood and incidence rates of type 2 diabetes and coronary heart disease in adulthood

T2 - A cohort study

AU - Blond, Kim

AU - Vistisen, Dorte

AU - Aarestrup, Julie

AU - Bjerregaard, Lise G.

AU - Hudda, Mohammed T.

AU - Tjønneland, Anne

AU - Allin, Kristine H.

AU - Jørgensen, Marit E.

AU - Jensen, Britt W.

AU - Baker, Jennifer L.

N1 - Funding Information: This project received funding from The Novo Nordisk Foundation NNF17OC0028338. The funders had no role in the study design, data collection, data analyses, interpretation of results, preparation of the manuscript or the publication process. Funding Information: KB, JA, LGB, MTH, JLB, AT, BWJ and KHA report no conflicts of interest. DV reports shares in Novo Nordisk A/S and has received research grants from Bayer A/S, Sanofi Aventis, Novo Nordisk A/S and Boehringer Ingelheim. MEJ has received research grants from Astra Zeneca, AMGEN, Sanofi Aventis, Novo Nordisk A/S and Boehringer Ingelheim.

PY - 2022/9

Y1 - 2022/9

N2 - Aims: We examined associations between five body mass index (BMI) trajectories from ages 6–15 years and register-based adult-onset type 2 diabetes mellitus (T2D) and coronary heart disease (CHD) with and without adjustment for adult BMI. Methods: Child and adult BMI came from two Danish cohorts and 13,205 and 13,438 individuals were included in T2D and CHD analyses, respectively. Trajectories were estimated by latent class modelling. Incidence rate ratios (IRRs) were estimated with Poisson regression. Results: In models without adult BMI, compared to the lowest trajectory, among men the T2D IRRs were 0.92 (95 %CI:0.77–1.09) for the second lowest trajectory and 1.51 (95 %CI:0.71–3.20) for the highest trajectory. The corresponding IRRs in women were 0.92 (95 %CI:0.74–1.16) and 3.58 (95 %CI:2.30–5.57). In models including adult BMI, compared to the lowest trajectory, T2D IRRs in men were 0.57 (95 %CI:0.47–0.68) for the second lowest trajectory and 0.26 (95 %CI:0.12–0.56) for the highest trajectory. The corresponding IRRs in women were 0.60 (95 %CI:0.48–0.75) and 0.59 (95 %CI:0.36–0.96). The associations were similar in direction, but not statistically significant, for CHD. Conclusions: Incidence rates of adult-onset T2D were greater for a high child BMI trajectory than a low child BMI trajectory, but not in models that included adult BMI.

AB - Aims: We examined associations between five body mass index (BMI) trajectories from ages 6–15 years and register-based adult-onset type 2 diabetes mellitus (T2D) and coronary heart disease (CHD) with and without adjustment for adult BMI. Methods: Child and adult BMI came from two Danish cohorts and 13,205 and 13,438 individuals were included in T2D and CHD analyses, respectively. Trajectories were estimated by latent class modelling. Incidence rate ratios (IRRs) were estimated with Poisson regression. Results: In models without adult BMI, compared to the lowest trajectory, among men the T2D IRRs were 0.92 (95 %CI:0.77–1.09) for the second lowest trajectory and 1.51 (95 %CI:0.71–3.20) for the highest trajectory. The corresponding IRRs in women were 0.92 (95 %CI:0.74–1.16) and 3.58 (95 %CI:2.30–5.57). In models including adult BMI, compared to the lowest trajectory, T2D IRRs in men were 0.57 (95 %CI:0.47–0.68) for the second lowest trajectory and 0.26 (95 %CI:0.12–0.56) for the highest trajectory. The corresponding IRRs in women were 0.60 (95 %CI:0.48–0.75) and 0.59 (95 %CI:0.36–0.96). The associations were similar in direction, but not statistically significant, for CHD. Conclusions: Incidence rates of adult-onset T2D were greater for a high child BMI trajectory than a low child BMI trajectory, but not in models that included adult BMI.

KW - Body mass index

KW - Cardiovascular diseases

KW - Diabetes mellitus

KW - Type 2

U2 - 10.1016/j.diabres.2022.110055

DO - 10.1016/j.diabres.2022.110055

M3 - Journal article

C2 - 36041552

AN - SCOPUS:85137276134

SN - 0168-8227

VL - 191

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

M1 - 110055

ER -

Body mass index trajectories in childhood and incidence rates of type 2 diabetes and coronary heart disease in adulthood: A cohort study

Abstract

Bibliografisk note

Dokumenter og links

SDU link

Fingeraftryk

Citationsformater