Body Mass Index and Risk of Infections Among Women in the Danish National Birth Cohort

Maria C Harpsøe, Nete M Nielsen, Nina Friis-Møller, Mikael Andersson, Jan Wohlfahrt, Allan Linneberg, Ellen A Nohr, Tine Jess

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

We investigated the possible association between body mass index (BMI; weight (kg)/height (m)(2)) and hospitalization or treatment for acute infection in a prospective cohort study. We linked 75,001 women enrolled in the Danish National Birth Cohort from 1996 to 2002, who had information on BMI and a broad range of confounders, to data on infectious diseases and use of antimicrobial agents from the National Patient Register and the Danish Prescription Register. Associations were tested using Cox proportional hazards models. During 12 years of follow-up, we observed a U-shaped association between baseline BMI and later hospitalization for 1) any infectious disease and 2) infections of the respiratory tract, whereas a dose-response relationship was seen for skin infections. The most pronounced associations were seen for acute upper respiratory infections at multiple and unspecified sites (underweight (BMI <18.5): hazard ratio (HR) = 4.26, 95% confidence interval (CI): 1.69, 10.7; obesity (BMI ≥30): HR = 3.64, 95% CI: 1.62, 8.18), erysipelas (obesity: HR = 5.19, 95% CI: 3.38, 7.95), and fungal infections (underweight: HR = 3.19, 95% CI: 1.53, 6.66). Slightly greater use of antimicrobials was observed among overweight (BMI 25-<30; HR = 1.08, 95% CI: 1.06, 1.10) and obese (HR = 1.21, 95% CI: 1.17, 1.24) women. Among Danish women, underweight and obesity were associated with increased risk of community-acquired infectious diseases, especially infections of the upper respiratory tract and skin.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Epidemiology
Vol/bind183
Udgave nummer11
Sider (fra-til)1008-1017
ISSN0002-9262
DOI
StatusUdgivet - 2016

Fingeraftryk

Body Mass Index
Confidence Intervals
Erysipelas
Skin
Proportional Hazards Models
Prescriptions
Cohort Studies
Prospective Studies
Weights and Measures

Citer dette

Harpsøe, M. C., Nielsen, N. M., Friis-Møller, N., Andersson, M., Wohlfahrt, J., Linneberg, A., ... Jess, T. (2016). Body Mass Index and Risk of Infections Among Women in the Danish National Birth Cohort. American Journal of Epidemiology, 183(11), 1008-1017. https://doi.org/10.1093/aje/kwv300
Harpsøe, Maria C ; Nielsen, Nete M ; Friis-Møller, Nina ; Andersson, Mikael ; Wohlfahrt, Jan ; Linneberg, Allan ; Nohr, Ellen A ; Jess, Tine. / Body Mass Index and Risk of Infections Among Women in the Danish National Birth Cohort. I: American Journal of Epidemiology. 2016 ; Bind 183, Nr. 11. s. 1008-1017.
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abstract = "We investigated the possible association between body mass index (BMI; weight (kg)/height (m)(2)) and hospitalization or treatment for acute infection in a prospective cohort study. We linked 75,001 women enrolled in the Danish National Birth Cohort from 1996 to 2002, who had information on BMI and a broad range of confounders, to data on infectious diseases and use of antimicrobial agents from the National Patient Register and the Danish Prescription Register. Associations were tested using Cox proportional hazards models. During 12 years of follow-up, we observed a U-shaped association between baseline BMI and later hospitalization for 1) any infectious disease and 2) infections of the respiratory tract, whereas a dose-response relationship was seen for skin infections. The most pronounced associations were seen for acute upper respiratory infections at multiple and unspecified sites (underweight (BMI <18.5): hazard ratio (HR) = 4.26, 95{\%} confidence interval (CI): 1.69, 10.7; obesity (BMI ≥30): HR = 3.64, 95{\%} CI: 1.62, 8.18), erysipelas (obesity: HR = 5.19, 95{\%} CI: 3.38, 7.95), and fungal infections (underweight: HR = 3.19, 95{\%} CI: 1.53, 6.66). Slightly greater use of antimicrobials was observed among overweight (BMI 25-<30; HR = 1.08, 95{\%} CI: 1.06, 1.10) and obese (HR = 1.21, 95{\%} CI: 1.17, 1.24) women. Among Danish women, underweight and obesity were associated with increased risk of community-acquired infectious diseases, especially infections of the upper respiratory tract and skin.",
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Harpsøe, MC, Nielsen, NM, Friis-Møller, N, Andersson, M, Wohlfahrt, J, Linneberg, A, Nohr, EA & Jess, T 2016, 'Body Mass Index and Risk of Infections Among Women in the Danish National Birth Cohort', American Journal of Epidemiology, bind 183, nr. 11, s. 1008-1017. https://doi.org/10.1093/aje/kwv300

Body Mass Index and Risk of Infections Among Women in the Danish National Birth Cohort. / Harpsøe, Maria C; Nielsen, Nete M; Friis-Møller, Nina; Andersson, Mikael; Wohlfahrt, Jan; Linneberg, Allan; Nohr, Ellen A; Jess, Tine.

I: American Journal of Epidemiology, Bind 183, Nr. 11, 2016, s. 1008-1017.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Body Mass Index and Risk of Infections Among Women in the Danish National Birth Cohort

AU - Harpsøe, Maria C

AU - Nielsen, Nete M

AU - Friis-Møller, Nina

AU - Andersson, Mikael

AU - Wohlfahrt, Jan

AU - Linneberg, Allan

AU - Nohr, Ellen A

AU - Jess, Tine

N1 - © The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2016

Y1 - 2016

N2 - We investigated the possible association between body mass index (BMI; weight (kg)/height (m)(2)) and hospitalization or treatment for acute infection in a prospective cohort study. We linked 75,001 women enrolled in the Danish National Birth Cohort from 1996 to 2002, who had information on BMI and a broad range of confounders, to data on infectious diseases and use of antimicrobial agents from the National Patient Register and the Danish Prescription Register. Associations were tested using Cox proportional hazards models. During 12 years of follow-up, we observed a U-shaped association between baseline BMI and later hospitalization for 1) any infectious disease and 2) infections of the respiratory tract, whereas a dose-response relationship was seen for skin infections. The most pronounced associations were seen for acute upper respiratory infections at multiple and unspecified sites (underweight (BMI <18.5): hazard ratio (HR) = 4.26, 95% confidence interval (CI): 1.69, 10.7; obesity (BMI ≥30): HR = 3.64, 95% CI: 1.62, 8.18), erysipelas (obesity: HR = 5.19, 95% CI: 3.38, 7.95), and fungal infections (underweight: HR = 3.19, 95% CI: 1.53, 6.66). Slightly greater use of antimicrobials was observed among overweight (BMI 25-<30; HR = 1.08, 95% CI: 1.06, 1.10) and obese (HR = 1.21, 95% CI: 1.17, 1.24) women. Among Danish women, underweight and obesity were associated with increased risk of community-acquired infectious diseases, especially infections of the upper respiratory tract and skin.

AB - We investigated the possible association between body mass index (BMI; weight (kg)/height (m)(2)) and hospitalization or treatment for acute infection in a prospective cohort study. We linked 75,001 women enrolled in the Danish National Birth Cohort from 1996 to 2002, who had information on BMI and a broad range of confounders, to data on infectious diseases and use of antimicrobial agents from the National Patient Register and the Danish Prescription Register. Associations were tested using Cox proportional hazards models. During 12 years of follow-up, we observed a U-shaped association between baseline BMI and later hospitalization for 1) any infectious disease and 2) infections of the respiratory tract, whereas a dose-response relationship was seen for skin infections. The most pronounced associations were seen for acute upper respiratory infections at multiple and unspecified sites (underweight (BMI <18.5): hazard ratio (HR) = 4.26, 95% confidence interval (CI): 1.69, 10.7; obesity (BMI ≥30): HR = 3.64, 95% CI: 1.62, 8.18), erysipelas (obesity: HR = 5.19, 95% CI: 3.38, 7.95), and fungal infections (underweight: HR = 3.19, 95% CI: 1.53, 6.66). Slightly greater use of antimicrobials was observed among overweight (BMI 25-<30; HR = 1.08, 95% CI: 1.06, 1.10) and obese (HR = 1.21, 95% CI: 1.17, 1.24) women. Among Danish women, underweight and obesity were associated with increased risk of community-acquired infectious diseases, especially infections of the upper respiratory tract and skin.

KW - Journal Article

U2 - 10.1093/aje/kwv300

DO - 10.1093/aje/kwv300

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VL - 183

SP - 1008

EP - 1017

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

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ER -

Harpsøe MC, Nielsen NM, Friis-Møller N, Andersson M, Wohlfahrt J, Linneberg A et al. Body Mass Index and Risk of Infections Among Women in the Danish National Birth Cohort. American Journal of Epidemiology. 2016;183(11):1008-1017. https://doi.org/10.1093/aje/kwv300