Blood-based biomarker in Parkinson’s disease: potential for future applications in clinical research and practice

Lars Tönges*, Carsten Buhmann, Stephan Klebe, Jochen Klucken, Eun Hae Kwon, Thomas Müller, David J. Pedrosa, Nils Schröter, Peter Riederer, Paul Lingor

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Abstract

The clinical presentation of Parkinson’s disease (PD) is both complex and heterogeneous, and its precise classification often requires an intensive work-up. The differential diagnosis, assessment of disease progression, evaluation of therapeutic responses, or identification of PD subtypes frequently remains uncertain from a clinical point of view. Various tissue- and fluid-based biomarkers are currently being investigated to improve the description of PD. From a clinician's perspective, signatures from blood that are relatively easy to obtain would have great potential for use in clinical practice if they fulfill the necessary requirements as PD biomarker. In this review article, we summarize the knowledge on blood-based PD biomarkers and present both a researcher’s and a clinician’s perspective on recent developments and potential future applications.

OriginalsprogEngelsk
TidsskriftJournal of Neural Transmission
Vol/bind129
Udgave nummer9
Sider (fra-til)1201-1217
ISSN0300-9564
DOI
StatusUdgivet - sep. 2022

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© 2022, The Author(s).

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