Biomolecular Recognition of Methylated Histones

Miriam Porzberg, Bas J.G.E. Pieters, Jasmin Mecinovic

Publikation: Kapitel i bog/rapport/konference-proceedingKapitel i bogForskningpeer review

Abstrakt

Lysineandargininemethylations areamongthemostabundantposttranslational modifications found on histone proteins. The recognition of methylated lysine and arginine residues by epigenetic reader proteins provides an important molecular requirement for regulation of human genes. Recent structural and mechanistic studies importantly advanced our basic understanding of biomolecular recognition of methylated histones by diverse classes of epigenetic readers. In this chapter, we describe chemical biological studies on the recognition of methylated histones by the aromatic cage-containing reader proteins.
OriginalsprogEngelsk
TitelThe DNA, RNA, and Histone Methylomes
Antal sider17
ForlagSpringer
Publikationsdato29. aug. 2019
Sider435-451
ISBN (Trykt)978-3-030-14791-4
ISBN (Elektronisk)978-3-030-14792-1
DOI
StatusUdgivet - 29. aug. 2019
NavnRNA Technologies (RNATECHN)
ISSN2197-9758

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