Biochemical characterization of early osteoarthritis in the ankle

Hagen Schmal, Gian M Salzmann, Elia R Langenmair, Ralf Henkelmann, Norbert P Südkamp, Philipp Niemeyer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

PURPOSE: Reliable data about in vivo regulation of cytokines in early ankle osteoarthritis (OA) are still missing.

METHODS: 49 patients with a mean age of 33 ± 14 years undergoing an arthroscopy of the ankle with different stages of chronic OA were prospectively included in a clinical trial. Lavage fluids were analyzed by ELISA. Additionally, clinical parameters and scores (FFI, CFSS, and AOFAS) were evaluated and supplemented by the Kellgren Lawrence Score (KLS) and the ankle osteoarthritis scoring system (AOSS).

RESULTS: ICRS grading of cartilage damage, previous operations, and duration of complains were strong indicators for OA progress and showed correlations to age, clinical scores, validated KLS, and AOSS (P < 0.04). Systemic and intraarticular inflammatory parameters were low in all patients. Biochemically, aggrecan and BMP-7 positively indicated OA with statistically significant associations with duration of symptoms, FFI, AOFAS, and KLS (P < 0.04). In contrast, BMP-2 levels showed statistically significant negative correlations to aggrecan or BMP-7 concentrations, which is in line with the negative association with ICRS score and KLS and the positive correlation with FFI (P < 0.03).

CONCLUSIONS: We were able to identify different key markers of OA in the ankle as aggrecan, BMP-7, and BMP-2, offering starting points for new ways in diagnostics and interventional strategies.

OriginalsprogEngelsk
Artikelnummer434802
TidsskriftThe Scientific World Journal
Vol/bind2014
Antal sider9
ISSN2356-6140
DOI
StatusUdgivet - 2014
Udgivet eksterntJa

Fingeraftryk

Bone Morphogenetic Protein 7
Aggrecans
Cartilage
Cytokines
damage
Fluids
fluid
Clinical Trials
parameter

Citer dette

Schmal, H., Salzmann, G. M., Langenmair, E. R., Henkelmann, R., Südkamp, N. P., & Niemeyer, P. (2014). Biochemical characterization of early osteoarthritis in the ankle. The Scientific World Journal, 2014, [434802]. https://doi.org/10.1155/2014/434802
Schmal, Hagen ; Salzmann, Gian M ; Langenmair, Elia R ; Henkelmann, Ralf ; Südkamp, Norbert P ; Niemeyer, Philipp. / Biochemical characterization of early osteoarthritis in the ankle. I: The Scientific World Journal. 2014 ; Bind 2014.
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abstract = "PURPOSE: Reliable data about in vivo regulation of cytokines in early ankle osteoarthritis (OA) are still missing.METHODS: 49 patients with a mean age of 33 ± 14 years undergoing an arthroscopy of the ankle with different stages of chronic OA were prospectively included in a clinical trial. Lavage fluids were analyzed by ELISA. Additionally, clinical parameters and scores (FFI, CFSS, and AOFAS) were evaluated and supplemented by the Kellgren Lawrence Score (KLS) and the ankle osteoarthritis scoring system (AOSS).RESULTS: ICRS grading of cartilage damage, previous operations, and duration of complains were strong indicators for OA progress and showed correlations to age, clinical scores, validated KLS, and AOSS (P < 0.04). Systemic and intraarticular inflammatory parameters were low in all patients. Biochemically, aggrecan and BMP-7 positively indicated OA with statistically significant associations with duration of symptoms, FFI, AOFAS, and KLS (P < 0.04). In contrast, BMP-2 levels showed statistically significant negative correlations to aggrecan or BMP-7 concentrations, which is in line with the negative association with ICRS score and KLS and the positive correlation with FFI (P < 0.03).CONCLUSIONS: We were able to identify different key markers of OA in the ankle as aggrecan, BMP-7, and BMP-2, offering starting points for new ways in diagnostics and interventional strategies.",
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Schmal, H, Salzmann, GM, Langenmair, ER, Henkelmann, R, Südkamp, NP & Niemeyer, P 2014, 'Biochemical characterization of early osteoarthritis in the ankle', The Scientific World Journal, bind 2014, 434802. https://doi.org/10.1155/2014/434802

Biochemical characterization of early osteoarthritis in the ankle. / Schmal, Hagen; Salzmann, Gian M; Langenmair, Elia R; Henkelmann, Ralf; Südkamp, Norbert P; Niemeyer, Philipp.

I: The Scientific World Journal, Bind 2014, 434802, 2014.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Biochemical characterization of early osteoarthritis in the ankle

AU - Schmal, Hagen

AU - Salzmann, Gian M

AU - Langenmair, Elia R

AU - Henkelmann, Ralf

AU - Südkamp, Norbert P

AU - Niemeyer, Philipp

PY - 2014

Y1 - 2014

N2 - PURPOSE: Reliable data about in vivo regulation of cytokines in early ankle osteoarthritis (OA) are still missing.METHODS: 49 patients with a mean age of 33 ± 14 years undergoing an arthroscopy of the ankle with different stages of chronic OA were prospectively included in a clinical trial. Lavage fluids were analyzed by ELISA. Additionally, clinical parameters and scores (FFI, CFSS, and AOFAS) were evaluated and supplemented by the Kellgren Lawrence Score (KLS) and the ankle osteoarthritis scoring system (AOSS).RESULTS: ICRS grading of cartilage damage, previous operations, and duration of complains were strong indicators for OA progress and showed correlations to age, clinical scores, validated KLS, and AOSS (P < 0.04). Systemic and intraarticular inflammatory parameters were low in all patients. Biochemically, aggrecan and BMP-7 positively indicated OA with statistically significant associations with duration of symptoms, FFI, AOFAS, and KLS (P < 0.04). In contrast, BMP-2 levels showed statistically significant negative correlations to aggrecan or BMP-7 concentrations, which is in line with the negative association with ICRS score and KLS and the positive correlation with FFI (P < 0.03).CONCLUSIONS: We were able to identify different key markers of OA in the ankle as aggrecan, BMP-7, and BMP-2, offering starting points for new ways in diagnostics and interventional strategies.

AB - PURPOSE: Reliable data about in vivo regulation of cytokines in early ankle osteoarthritis (OA) are still missing.METHODS: 49 patients with a mean age of 33 ± 14 years undergoing an arthroscopy of the ankle with different stages of chronic OA were prospectively included in a clinical trial. Lavage fluids were analyzed by ELISA. Additionally, clinical parameters and scores (FFI, CFSS, and AOFAS) were evaluated and supplemented by the Kellgren Lawrence Score (KLS) and the ankle osteoarthritis scoring system (AOSS).RESULTS: ICRS grading of cartilage damage, previous operations, and duration of complains were strong indicators for OA progress and showed correlations to age, clinical scores, validated KLS, and AOSS (P < 0.04). Systemic and intraarticular inflammatory parameters were low in all patients. Biochemically, aggrecan and BMP-7 positively indicated OA with statistically significant associations with duration of symptoms, FFI, AOFAS, and KLS (P < 0.04). In contrast, BMP-2 levels showed statistically significant negative correlations to aggrecan or BMP-7 concentrations, which is in line with the negative association with ICRS score and KLS and the positive correlation with FFI (P < 0.03).CONCLUSIONS: We were able to identify different key markers of OA in the ankle as aggrecan, BMP-7, and BMP-2, offering starting points for new ways in diagnostics and interventional strategies.

KW - Adult

KW - Aggrecans

KW - Ankle Joint

KW - Biomarkers

KW - Bone Morphogenetic Protein 2

KW - Bone Morphogenetic Protein 7

KW - Early Diagnosis

KW - Female

KW - Humans

KW - Osteoarthritis

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Synovial Fluid

KW - Clinical Trial

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1155/2014/434802

DO - 10.1155/2014/434802

M3 - Journal article

VL - 2014

JO - Scientific World Journal

JF - Scientific World Journal

SN - 2356-6140

M1 - 434802

ER -

Schmal H, Salzmann GM, Langenmair ER, Henkelmann R, Südkamp NP, Niemeyer P. Biochemical characterization of early osteoarthritis in the ankle. The Scientific World Journal. 2014;2014. 434802. https://doi.org/10.1155/2014/434802