Beta-cell function is associated with carotid intima-media thickness independently of insulin resistance in healthy individuals

Ronan Roussel*, Andrea Natali, Beverley Balkau, Kurt Højlund, Gabriel Sánchez, John Nolan, Andrea Mari, Michaela Kozakova, Fabrice Bonnet

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Objective: It is a common belief that early atherosclerosis in prediabetes is causally linked to endothelial insulin resistance. Another condition, a low insulin secretion, may be associated with insufficient insulin action on the vascular wall and consequently favor atherosclerosis. Our aim was to test this hypothesis in people without diabetes, taking into account the gold-standard measurement of insulin sensitivity, a major confounder in the relationship between insulin secretion and atherosclerosis. Methods: We studied the European Relationship between Insulin Sensitivity and Cardiovascular Risk cohort of 451 men and 593 women (44±8 years, mean±SD) who were free of diabetes, hypertension, dyslipidemia, and other known chronic or acute conditions. All underwent an oral glucose tolerance test, a euglycemic-hyperinsulinemic clamp (M/I measured insulin sensitivity), and B-mode carotid ultrasound. Results: Intima-media thickness (IMT) in the common carotid artery was negatively associated with insulin secretion indexes, with Spearman partial correlation coefficients: -0.09, -0.08, -0.06 for respectively, the disposition index, the early insulin response and the beta cell glucose sensitivity, after adjusting for established factors, including clamp-measured insulin sensitivity (all P<0.05). For quartiles 1 (lowest) to 4 of the disposition index, the covariate-adjusted geometric means of IMT (mm) were 0.605 (95% confidence interval: 0.596-0.614), 0.596 (0.587-0.605), 0.597 (0.587-0.606), and 0.586 (0.577-0.596) (P trend =0.004). Similar results were found for the two other surrogate measures of insulin secretion. No interaction with sex was observed. Conclusion: Insulin secretion was associated with early carotid atherosclerosis in nondiabetic individuals, independently of other risk factors, including insulin sensitivity measured by the gold-standard method.

OriginalsprogEngelsk
TidsskriftJournal of Hypertension
Vol/bind34
Udgave nummer4
Sider (fra-til)685-691
ISSN0263-6352
DOI
StatusUdgivet - 2016

Fingeraftryk

Insulin Resistance
Insulin
Gold
Prediabetic State
Glucose Clamp Technique
Glucose Tolerance Test
Dyslipidemias
Confidence Intervals

Citer dette

Roussel, Ronan ; Natali, Andrea ; Balkau, Beverley ; Højlund, Kurt ; Sánchez, Gabriel ; Nolan, John ; Mari, Andrea ; Kozakova, Michaela ; Bonnet, Fabrice. / Beta-cell function is associated with carotid intima-media thickness independently of insulin resistance in healthy individuals. I: Journal of Hypertension. 2016 ; Bind 34, Nr. 4. s. 685-691.
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title = "Beta-cell function is associated with carotid intima-media thickness independently of insulin resistance in healthy individuals",
abstract = "Objective: It is a common belief that early atherosclerosis in prediabetes is causally linked to endothelial insulin resistance. Another condition, a low insulin secretion, may be associated with insufficient insulin action on the vascular wall and consequently favor atherosclerosis. Our aim was to test this hypothesis in people without diabetes, taking into account the gold-standard measurement of insulin sensitivity, a major confounder in the relationship between insulin secretion and atherosclerosis. Methods: We studied the European Relationship between Insulin Sensitivity and Cardiovascular Risk cohort of 451 men and 593 women (44±8 years, mean±SD) who were free of diabetes, hypertension, dyslipidemia, and other known chronic or acute conditions. All underwent an oral glucose tolerance test, a euglycemic-hyperinsulinemic clamp (M/I measured insulin sensitivity), and B-mode carotid ultrasound. Results: Intima-media thickness (IMT) in the common carotid artery was negatively associated with insulin secretion indexes, with Spearman partial correlation coefficients: -0.09, -0.08, -0.06 for respectively, the disposition index, the early insulin response and the beta cell glucose sensitivity, after adjusting for established factors, including clamp-measured insulin sensitivity (all P<0.05). For quartiles 1 (lowest) to 4 of the disposition index, the covariate-adjusted geometric means of IMT (mm) were 0.605 (95{\%} confidence interval: 0.596-0.614), 0.596 (0.587-0.605), 0.597 (0.587-0.606), and 0.586 (0.577-0.596) (P trend =0.004). Similar results were found for the two other surrogate measures of insulin secretion. No interaction with sex was observed. Conclusion: Insulin secretion was associated with early carotid atherosclerosis in nondiabetic individuals, independently of other risk factors, including insulin sensitivity measured by the gold-standard method.",
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author = "Ronan Roussel and Andrea Natali and Beverley Balkau and Kurt H{\o}jlund and Gabriel S{\'a}nchez and John Nolan and Andrea Mari and Michaela Kozakova and Fabrice Bonnet",
year = "2016",
doi = "10.1097/HJH.0000000000000842",
language = "English",
volume = "34",
pages = "685--691",
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Beta-cell function is associated with carotid intima-media thickness independently of insulin resistance in healthy individuals. / Roussel, Ronan; Natali, Andrea; Balkau, Beverley; Højlund, Kurt; Sánchez, Gabriel; Nolan, John; Mari, Andrea; Kozakova, Michaela; Bonnet, Fabrice.

I: Journal of Hypertension, Bind 34, Nr. 4, 2016, s. 685-691.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Beta-cell function is associated with carotid intima-media thickness independently of insulin resistance in healthy individuals

AU - Roussel, Ronan

AU - Natali, Andrea

AU - Balkau, Beverley

AU - Højlund, Kurt

AU - Sánchez, Gabriel

AU - Nolan, John

AU - Mari, Andrea

AU - Kozakova, Michaela

AU - Bonnet, Fabrice

PY - 2016

Y1 - 2016

N2 - Objective: It is a common belief that early atherosclerosis in prediabetes is causally linked to endothelial insulin resistance. Another condition, a low insulin secretion, may be associated with insufficient insulin action on the vascular wall and consequently favor atherosclerosis. Our aim was to test this hypothesis in people without diabetes, taking into account the gold-standard measurement of insulin sensitivity, a major confounder in the relationship between insulin secretion and atherosclerosis. Methods: We studied the European Relationship between Insulin Sensitivity and Cardiovascular Risk cohort of 451 men and 593 women (44±8 years, mean±SD) who were free of diabetes, hypertension, dyslipidemia, and other known chronic or acute conditions. All underwent an oral glucose tolerance test, a euglycemic-hyperinsulinemic clamp (M/I measured insulin sensitivity), and B-mode carotid ultrasound. Results: Intima-media thickness (IMT) in the common carotid artery was negatively associated with insulin secretion indexes, with Spearman partial correlation coefficients: -0.09, -0.08, -0.06 for respectively, the disposition index, the early insulin response and the beta cell glucose sensitivity, after adjusting for established factors, including clamp-measured insulin sensitivity (all P<0.05). For quartiles 1 (lowest) to 4 of the disposition index, the covariate-adjusted geometric means of IMT (mm) were 0.605 (95% confidence interval: 0.596-0.614), 0.596 (0.587-0.605), 0.597 (0.587-0.606), and 0.586 (0.577-0.596) (P trend =0.004). Similar results were found for the two other surrogate measures of insulin secretion. No interaction with sex was observed. Conclusion: Insulin secretion was associated with early carotid atherosclerosis in nondiabetic individuals, independently of other risk factors, including insulin sensitivity measured by the gold-standard method.

AB - Objective: It is a common belief that early atherosclerosis in prediabetes is causally linked to endothelial insulin resistance. Another condition, a low insulin secretion, may be associated with insufficient insulin action on the vascular wall and consequently favor atherosclerosis. Our aim was to test this hypothesis in people without diabetes, taking into account the gold-standard measurement of insulin sensitivity, a major confounder in the relationship between insulin secretion and atherosclerosis. Methods: We studied the European Relationship between Insulin Sensitivity and Cardiovascular Risk cohort of 451 men and 593 women (44±8 years, mean±SD) who were free of diabetes, hypertension, dyslipidemia, and other known chronic or acute conditions. All underwent an oral glucose tolerance test, a euglycemic-hyperinsulinemic clamp (M/I measured insulin sensitivity), and B-mode carotid ultrasound. Results: Intima-media thickness (IMT) in the common carotid artery was negatively associated with insulin secretion indexes, with Spearman partial correlation coefficients: -0.09, -0.08, -0.06 for respectively, the disposition index, the early insulin response and the beta cell glucose sensitivity, after adjusting for established factors, including clamp-measured insulin sensitivity (all P<0.05). For quartiles 1 (lowest) to 4 of the disposition index, the covariate-adjusted geometric means of IMT (mm) were 0.605 (95% confidence interval: 0.596-0.614), 0.596 (0.587-0.605), 0.597 (0.587-0.606), and 0.586 (0.577-0.596) (P trend =0.004). Similar results were found for the two other surrogate measures of insulin secretion. No interaction with sex was observed. Conclusion: Insulin secretion was associated with early carotid atherosclerosis in nondiabetic individuals, independently of other risk factors, including insulin sensitivity measured by the gold-standard method.

KW - atherosclerosis

KW - diabetes mellitus

KW - epidemiology

KW - insulin resistance

KW - insulin secretion

U2 - 10.1097/HJH.0000000000000842

DO - 10.1097/HJH.0000000000000842

M3 - Journal article

VL - 34

SP - 685

EP - 691

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 4

ER -