Belief about nicotine Modulates subjective craving and insula activity in Deprived smokers

X. S. Gu, Terry Lohrenz, Ramiro Salas, P. R. Baldwin, Alireza Soltani, U. Kirk, Paul M Cinciripini, P Read Montague

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Resumé

Little is known about the specific neural mechanisms through which cognitive factors influence craving and associated brain responses, despite the initial success of cognitive therapies in treating drug addiction. In this study, we investigated how cognitive factors such as beliefs influence subjective craving and neural activities in nicotine-addicted individuals using model-based functional magnetic resonance imaging (fMRI) and neuropharmacology. Deprived smokers (N = 24) participated in a two-by-two balanced placebo design, which crossed beliefs about nicotine (told "nicotine" vs. told "no nicotine") with the nicotine content in a cigarette (nicotine vs. placebo) which participants smoked immediately before performing a fMRI task involving reward learning. Subjects' reported craving was measured both before smoking and after the fMRI session. We found that first, in the presence of nicotine, smokers demonstrated significantly reduced craving after smoking when told "nicotine in cigarette" but showed no change in craving when told "no nicotine." Second, neural activity in the insular cortex related to craving was only significant when smokers were told "nicotine" but not when told "no nicotine." Both effects were absent in the placebo condition. Third, insula activation related to computational learning signals was modulated by belief about nicotine regardless of nicotine's presence. These results suggest that belief about nicotine has a strong impact on subjective craving and insula responses related to both craving and learning in deprived smokers, providing insights into the complex nature of belief-drug interactions.
OriginalsprogEngelsk
Artikelnummer126
TidsskriftFrontiers in Psychiatry
Vol/bind7
Antal sider11
ISSN1664-0640
DOI
StatusUdgivet - 2016

Fingeraftryk

Nicotine
Placebos
Craving
Smoking
Neuropharmacology
Drug Interactions

Bibliografisk note

This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission

Citer dette

Gu, X. S. ; Lohrenz, Terry ; Salas, Ramiro ; Baldwin, P. R. ; Soltani, Alireza ; Kirk, U. ; Cinciripini, Paul M ; Montague, P Read. / Belief about nicotine Modulates subjective craving and insula activity in Deprived smokers. I: Frontiers in Psychiatry. 2016 ; Bind 7.
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abstract = "Little is known about the specific neural mechanisms through which cognitive factors influence craving and associated brain responses, despite the initial success of cognitive therapies in treating drug addiction. In this study, we investigated how cognitive factors such as beliefs influence subjective craving and neural activities in nicotine-addicted individuals using model-based functional magnetic resonance imaging (fMRI) and neuropharmacology. Deprived smokers (N = 24) participated in a two-by-two balanced placebo design, which crossed beliefs about nicotine (told {"}nicotine{"} vs. told {"}no nicotine{"}) with the nicotine content in a cigarette (nicotine vs. placebo) which participants smoked immediately before performing a fMRI task involving reward learning. Subjects' reported craving was measured both before smoking and after the fMRI session. We found that first, in the presence of nicotine, smokers demonstrated significantly reduced craving after smoking when told {"}nicotine in cigarette{"} but showed no change in craving when told {"}no nicotine.{"} Second, neural activity in the insular cortex related to craving was only significant when smokers were told {"}nicotine{"} but not when told {"}no nicotine.{"} Both effects were absent in the placebo condition. Third, insula activation related to computational learning signals was modulated by belief about nicotine regardless of nicotine's presence. These results suggest that belief about nicotine has a strong impact on subjective craving and insula responses related to both craving and learning in deprived smokers, providing insights into the complex nature of belief-drug interactions.",
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year = "2016",
doi = "10.3389/fpsyt.2016.00126",
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Gu, XS, Lohrenz, T, Salas, R, Baldwin, PR, Soltani, A, Kirk, U, Cinciripini, PM & Montague, PR 2016, 'Belief about nicotine Modulates subjective craving and insula activity in Deprived smokers', Frontiers in Psychiatry, bind 7, 126. https://doi.org/10.3389/fpsyt.2016.00126

Belief about nicotine Modulates subjective craving and insula activity in Deprived smokers. / Gu, X. S.; Lohrenz, Terry ; Salas, Ramiro; Baldwin, P. R.; Soltani, Alireza; Kirk, U.; Cinciripini, Paul M; Montague, P Read.

I: Frontiers in Psychiatry, Bind 7, 126, 2016.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Belief about nicotine Modulates subjective craving and insula activity in Deprived smokers

AU - Gu, X. S.

AU - Lohrenz, Terry

AU - Salas, Ramiro

AU - Baldwin, P. R.

AU - Soltani, Alireza

AU - Kirk, U.

AU - Cinciripini, Paul M

AU - Montague, P Read

N1 - This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission

PY - 2016

Y1 - 2016

N2 - Little is known about the specific neural mechanisms through which cognitive factors influence craving and associated brain responses, despite the initial success of cognitive therapies in treating drug addiction. In this study, we investigated how cognitive factors such as beliefs influence subjective craving and neural activities in nicotine-addicted individuals using model-based functional magnetic resonance imaging (fMRI) and neuropharmacology. Deprived smokers (N = 24) participated in a two-by-two balanced placebo design, which crossed beliefs about nicotine (told "nicotine" vs. told "no nicotine") with the nicotine content in a cigarette (nicotine vs. placebo) which participants smoked immediately before performing a fMRI task involving reward learning. Subjects' reported craving was measured both before smoking and after the fMRI session. We found that first, in the presence of nicotine, smokers demonstrated significantly reduced craving after smoking when told "nicotine in cigarette" but showed no change in craving when told "no nicotine." Second, neural activity in the insular cortex related to craving was only significant when smokers were told "nicotine" but not when told "no nicotine." Both effects were absent in the placebo condition. Third, insula activation related to computational learning signals was modulated by belief about nicotine regardless of nicotine's presence. These results suggest that belief about nicotine has a strong impact on subjective craving and insula responses related to both craving and learning in deprived smokers, providing insights into the complex nature of belief-drug interactions.

AB - Little is known about the specific neural mechanisms through which cognitive factors influence craving and associated brain responses, despite the initial success of cognitive therapies in treating drug addiction. In this study, we investigated how cognitive factors such as beliefs influence subjective craving and neural activities in nicotine-addicted individuals using model-based functional magnetic resonance imaging (fMRI) and neuropharmacology. Deprived smokers (N = 24) participated in a two-by-two balanced placebo design, which crossed beliefs about nicotine (told "nicotine" vs. told "no nicotine") with the nicotine content in a cigarette (nicotine vs. placebo) which participants smoked immediately before performing a fMRI task involving reward learning. Subjects' reported craving was measured both before smoking and after the fMRI session. We found that first, in the presence of nicotine, smokers demonstrated significantly reduced craving after smoking when told "nicotine in cigarette" but showed no change in craving when told "no nicotine." Second, neural activity in the insular cortex related to craving was only significant when smokers were told "nicotine" but not when told "no nicotine." Both effects were absent in the placebo condition. Third, insula activation related to computational learning signals was modulated by belief about nicotine regardless of nicotine's presence. These results suggest that belief about nicotine has a strong impact on subjective craving and insula responses related to both craving and learning in deprived smokers, providing insights into the complex nature of belief-drug interactions.

KW - nicotine addiction belief craving interoception insula fMRI sequential investment task prediction error signals decision-making brain responses interoceptive inference prefrontal cortex cigarette smokers neural substrate drug-addiction tobacco use Psychia

U2 - 10.3389/fpsyt.2016.00126

DO - 10.3389/fpsyt.2016.00126

M3 - Journal article

C2 - 27468271

VL - 7

JO - Frontiers in Psychiatry

JF - Frontiers in Psychiatry

SN - 1664-0640

M1 - 126

ER -