Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent

Ragna Berthelsen, Carsten Uhd Nielsen, Birger Brodin

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Transepithelial di/tripeptide transport in enterocytes occurs via the apical proton-coupled peptide transporter, hPEPT1 (SLC15A1) and a basolateral peptide transporter, which has only been characterized functionally. In this study we examined the pH dependency, substrate uptake kinetics and substrate specificity of the transporter.
OriginalsprogEngelsk
TidsskriftJournal of Pharmacy and Pharmacology
Vol/bind65
Udgave nummer7
Sider (fra-til)970-9
Antal sider10
ISSN0022-3573
DOI
StatusUdgivet - jul. 2013
Udgivet eksterntJa

Fingeraftryk

Caco-2 Cells
Enterocytes
Protons
peptide permease

Citer dette

@article{2593a50b0ab746618e7ba42a1c9768cb,
title = "Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent",
abstract = "Transepithelial di/tripeptide transport in enterocytes occurs via the apical proton-coupled peptide transporter, hPEPT1 (SLC15A1) and a basolateral peptide transporter, which has only been characterized functionally. In this study we examined the pH dependency, substrate uptake kinetics and substrate specificity of the transporter.",
author = "Ragna Berthelsen and Nielsen, {Carsten Uhd} and Birger Brodin",
note = "{\circledC} 2013 Royal Pharmaceutical Society.",
year = "2013",
month = "7",
doi = "10.1111/jphp.12061",
language = "English",
volume = "65",
pages = "970--9",
journal = "Journal of Pharmacy and Pharmacology",
issn = "0022-3573",
publisher = "JohnWiley & Sons Ltd.",
number = "7",

}

Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent. / Berthelsen, Ragna; Nielsen, Carsten Uhd; Brodin, Birger.

I: Journal of Pharmacy and Pharmacology, Bind 65, Nr. 7, 07.2013, s. 970-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent

AU - Berthelsen, Ragna

AU - Nielsen, Carsten Uhd

AU - Brodin, Birger

N1 - © 2013 Royal Pharmaceutical Society.

PY - 2013/7

Y1 - 2013/7

N2 - Transepithelial di/tripeptide transport in enterocytes occurs via the apical proton-coupled peptide transporter, hPEPT1 (SLC15A1) and a basolateral peptide transporter, which has only been characterized functionally. In this study we examined the pH dependency, substrate uptake kinetics and substrate specificity of the transporter.

AB - Transepithelial di/tripeptide transport in enterocytes occurs via the apical proton-coupled peptide transporter, hPEPT1 (SLC15A1) and a basolateral peptide transporter, which has only been characterized functionally. In this study we examined the pH dependency, substrate uptake kinetics and substrate specificity of the transporter.

U2 - 10.1111/jphp.12061

DO - 10.1111/jphp.12061

M3 - Journal article

C2 - 23738724

VL - 65

SP - 970

EP - 979

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - 7

ER -