Bakteriel meningitis i Danmark 2002 og 2003: Landsdækkende registrering baseret på laboratoriedata

Christian N. Meyer*, Henrik C. Schønheyder, Jette Bangsborg, Xiaohui C. Nielsen, Jens K. Møller, Kåre Mølbak, André Korshin, Elisabeth Rønneberg, Rasmus Køster-Rasmussen, Niels Høiby, Esad Dzajic, Jens J. Christensen, Christian Østergaard, Brita Bruun, Henrik Friis, Ram Dessau, Hanne Holt, Poul Kjældgaard, Steffen Strøbæk, Peter K. SørensenJørgen Prag, Helga Schumacher, Johan Kjærgaard

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Abstrakt

Notification of bacterial meningitis (BM) is likely to be incomplete, and a recent Danish study indicated that unbalanced notification may bias expected aetiology of BM. Therefore the Danish Bacterial Meningitis Group initiated a national registration of culture-positive BM. Methods: Laboratory data on all bacterial isolates from cerebrospinal fluid deemed to be clinically relevant were identified on a national basis during 2002 and 2003. Bacterial findings were compared to cases notified during the same period. Results: A total of 404 BM cases were identified. The distribution of bacterial species differed from the national notification data during the same period especially with respect to Staphylococcus aureus (6.7% vs. 0.6%), Eschericha coli (3.5% vs. 0%) and non-Streptococcus pneumoniae streptococci (10% vs. 1.9%). The overall notification-rate was 66%, and was below 20% for S. aureus, E. coli, Enterococcus faecalis, non- S. pneumoniae streptococci and for 13 cases of "other bacteria". Sensitivity to antibiotics in the BM cases was as expected for Northern Europe. Reduced sensitivity to penicillin was found in 2/202 S. pneumoniae, in 2/10 Listeria monocytogenes, and 21/27 S. aureus were penicillin resistant. E. coli was resistant to ampicillin in 5 of 13 cases and to gentamicin in 1 of 11 cases. Discussion: A suboptimal notification rate with an unbalanced species distribution was found. Laboratory based data thus constitute an improved basis for future recommendations for empirical treatment of BM. A continued national collaboration may promote the development of quality indicators for diagnosis and initial treatment of BM.

OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind169
Udgave nummer6
Sider (fra-til)503-506
Antal sider4
ISSN0041-5782
StatusUdgivet - 5. feb. 2007

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Citationsformater

Meyer, C. N., Schønheyder, H. C., Bangsborg, J., Nielsen, X. C., Møller, J. K., Mølbak, K., Korshin, A., Rønneberg, E., Køster-Rasmussen, R., Høiby, N., Dzajic, E., Christensen, J. J., Østergaard, C., Bruun, B., Friis, H., Dessau, R., Holt, H., Kjældgaard, P., Strøbæk, S., ... Kjærgaard, J. (2007). Bakteriel meningitis i Danmark 2002 og 2003: Landsdækkende registrering baseret på laboratoriedata. Ugeskrift for Laeger, 169(6), 503-506.