Bacteremia is associated with excess long-term mortality: A 12-year population-based cohort study

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Resumé

OBJECTIVES: Little is known about long-term outcomes following bacteremia. We investigated long-term mortality and causes of death among bacteremia patients compared with population controls.

METHODS: Population-based cohort study of bacteremia patients and population controls matched on sex, year of birth, residency and calendar time, in Denmark during 2000-2008. We calculated absolute mortality and adjusted mortality rate ratios (MRRs) in predefined follow-up periods.

RESULTS: The absolute mortality for bacteremia patients (n = 7783) and population controls (n = 38,906) was 22.0% vs. 0.2% (30 days), 41.4% vs. 2.6% (1 year) and 75.8% vs. 36.6% (10 years). For bacteremia patients, the MRR was 115.3 (95% CI, 88.2-150.9) 0-30 days after bacteremia and 2.1 (95% CI, 1.8-2.3) from 5 years to end of follow-up. The most common causes of death were cancer and cardiovascular diseases. Within one year of bacteremia, the relative risk of death was highest for genitourinary diseases and infectious diseases. Among one-year survivors of bacteremia, the relative risk of death was increased for all major causes of death.

CONCLUSIONS: Bacteremia is associated with a poor prognosis and considerable excess long-term mortality compared with the general population. The most common causes of death after bacteremia are cancer and cardiovascular diseases.

SUMMARY: This population-based cohort study reports an excess long-term mortality among 7783 bacteremia patients compared with matched population controls during 12 years of follow-up. We identified patients in particular risk of death and reported novel information on causes of death.

OriginalsprogEngelsk
TidsskriftJournal of Infection
Vol/bind70
Udgave nummer2
Sider (fra-til)111–126
ISSN0163-4453
DOI
StatusUdgivet - 2015

Fingeraftryk

compound A 12
Cohort Studies
Population
Population Control
Cause of Death
Denmark
Internship and Residency
Survivors
Neoplasms

Citer dette

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title = "Bacteremia is associated with excess long-term mortality: A 12-year population-based cohort study",
abstract = "OBJECTIVES: Little is known about long-term outcomes following bacteremia. We investigated long-term mortality and causes of death among bacteremia patients compared with population controls.METHODS: Population-based cohort study of bacteremia patients and population controls matched on sex, year of birth, residency and calendar time, in Denmark during 2000-2008. We calculated absolute mortality and adjusted mortality rate ratios (MRRs) in predefined follow-up periods.RESULTS: The absolute mortality for bacteremia patients (n = 7783) and population controls (n = 38,906) was 22.0{\%} vs. 0.2{\%} (30 days), 41.4{\%} vs. 2.6{\%} (1 year) and 75.8{\%} vs. 36.6{\%} (10 years). For bacteremia patients, the MRR was 115.3 (95{\%} CI, 88.2-150.9) 0-30 days after bacteremia and 2.1 (95{\%} CI, 1.8-2.3) from 5 years to end of follow-up. The most common causes of death were cancer and cardiovascular diseases. Within one year of bacteremia, the relative risk of death was highest for genitourinary diseases and infectious diseases. Among one-year survivors of bacteremia, the relative risk of death was increased for all major causes of death.CONCLUSIONS: Bacteremia is associated with a poor prognosis and considerable excess long-term mortality compared with the general population. The most common causes of death after bacteremia are cancer and cardiovascular diseases.SUMMARY: This population-based cohort study reports an excess long-term mortality among 7783 bacteremia patients compared with matched population controls during 12 years of follow-up. We identified patients in particular risk of death and reported novel information on causes of death.",
author = "Nielsen, {Stig L{\o}nberg} and Lassen, {Annmarie Touborg} and Gradel, {Kim Oren} and Jensen, {Th{\o}ger Gorm} and Kolmos, {Hans J{\o}rn} and Jesper Hallas and Court Pedersen",
note = "Copyright {\circledC} 2014. Published by Elsevier Ltd.",
year = "2015",
doi = "10.1016/j.jinf.2014.08.012",
language = "English",
volume = "70",
pages = "111–126",
journal = "Journal of Infection",
issn = "0163-4453",
publisher = "W.B.Saunders Co. Ltd.",
number = "2",

}

TY - JOUR

T1 - Bacteremia is associated with excess long-term mortality

T2 - A 12-year population-based cohort study

AU - Nielsen, Stig Lønberg

AU - Lassen, Annmarie Touborg

AU - Gradel, Kim Oren

AU - Jensen, Thøger Gorm

AU - Kolmos, Hans Jørn

AU - Hallas, Jesper

AU - Pedersen, Court

N1 - Copyright © 2014. Published by Elsevier Ltd.

PY - 2015

Y1 - 2015

N2 - OBJECTIVES: Little is known about long-term outcomes following bacteremia. We investigated long-term mortality and causes of death among bacteremia patients compared with population controls.METHODS: Population-based cohort study of bacteremia patients and population controls matched on sex, year of birth, residency and calendar time, in Denmark during 2000-2008. We calculated absolute mortality and adjusted mortality rate ratios (MRRs) in predefined follow-up periods.RESULTS: The absolute mortality for bacteremia patients (n = 7783) and population controls (n = 38,906) was 22.0% vs. 0.2% (30 days), 41.4% vs. 2.6% (1 year) and 75.8% vs. 36.6% (10 years). For bacteremia patients, the MRR was 115.3 (95% CI, 88.2-150.9) 0-30 days after bacteremia and 2.1 (95% CI, 1.8-2.3) from 5 years to end of follow-up. The most common causes of death were cancer and cardiovascular diseases. Within one year of bacteremia, the relative risk of death was highest for genitourinary diseases and infectious diseases. Among one-year survivors of bacteremia, the relative risk of death was increased for all major causes of death.CONCLUSIONS: Bacteremia is associated with a poor prognosis and considerable excess long-term mortality compared with the general population. The most common causes of death after bacteremia are cancer and cardiovascular diseases.SUMMARY: This population-based cohort study reports an excess long-term mortality among 7783 bacteremia patients compared with matched population controls during 12 years of follow-up. We identified patients in particular risk of death and reported novel information on causes of death.

AB - OBJECTIVES: Little is known about long-term outcomes following bacteremia. We investigated long-term mortality and causes of death among bacteremia patients compared with population controls.METHODS: Population-based cohort study of bacteremia patients and population controls matched on sex, year of birth, residency and calendar time, in Denmark during 2000-2008. We calculated absolute mortality and adjusted mortality rate ratios (MRRs) in predefined follow-up periods.RESULTS: The absolute mortality for bacteremia patients (n = 7783) and population controls (n = 38,906) was 22.0% vs. 0.2% (30 days), 41.4% vs. 2.6% (1 year) and 75.8% vs. 36.6% (10 years). For bacteremia patients, the MRR was 115.3 (95% CI, 88.2-150.9) 0-30 days after bacteremia and 2.1 (95% CI, 1.8-2.3) from 5 years to end of follow-up. The most common causes of death were cancer and cardiovascular diseases. Within one year of bacteremia, the relative risk of death was highest for genitourinary diseases and infectious diseases. Among one-year survivors of bacteremia, the relative risk of death was increased for all major causes of death.CONCLUSIONS: Bacteremia is associated with a poor prognosis and considerable excess long-term mortality compared with the general population. The most common causes of death after bacteremia are cancer and cardiovascular diseases.SUMMARY: This population-based cohort study reports an excess long-term mortality among 7783 bacteremia patients compared with matched population controls during 12 years of follow-up. We identified patients in particular risk of death and reported novel information on causes of death.

U2 - 10.1016/j.jinf.2014.08.012

DO - 10.1016/j.jinf.2014.08.012

M3 - Journal article

C2 - 25218427

VL - 70

SP - 111

EP - 126

JO - Journal of Infection

JF - Journal of Infection

SN - 0163-4453

IS - 2

ER -