Axon-Dependent Patterning and Maintenance of Somatosensory Dendritic Arbors

Nelson J. Ramirez-Suarez, Helen M. Belalcazar, Christopher J. Salazar, Burcu Beyaz, Benjamin Raja, Ken C.Q. Nguyen, Kevin Celestrin, Julius Fredens, Nils J. Færgeman, David H. Hall, Hannes E. Bülow*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The mechanisms that pattern and maintain dendritic arbors are key to understanding the principles that govern nervous system assembly. The activity of presynaptic axons has long been known to shape dendrites, but activity-independent functions of axons in this process have remained elusive. Here, we show that in Caenorhabditis elegans, the axons of the ALA neuron control guidance and extension of the 1° dendrites of PVD somatosensory neurons independently of ALA activity. PVD 1° dendrites mimic ALA axon guidance defects in loss-of-function mutants for the extracellular matrix molecule MIG-6/Papilin or the UNC-6/Netrin pathway, suggesting that axon-dendrite adhesion is important for dendrite formation. We found that the SAX-7/L1CAM cell adhesion molecule engages in distinct molecular mechanisms to mediate extensions of PVD 1° dendrites and maintain the ALA-PVD axon-dendritic fascicle, respectively. Thus, axons can serve as critical scaffolds to pattern and maintain dendrites through contact-dependent but activity-independent mechanisms.

OriginalsprogEngelsk
TidsskriftDevelopmental Cell
Vol/bind48
Udgave nummer2
Sider (fra-til)229-244.e4
ISSN1534-5807
DOI
StatusUdgivet - 28. jan. 2019

Fingeraftryk

Dendrites
Maintenance
Physical vapor deposition
Neurons
Neural Cell Adhesion Molecule L1
Caenorhabditis elegans
Cell Adhesion Molecules
Neurology
Axons
Scaffolds
Nervous System
Adhesion
Defects
Molecules

Citer dette

Ramirez-Suarez, N. J., Belalcazar, H. M., Salazar, C. J., Beyaz, B., Raja, B., Nguyen, K. C. Q., ... Bülow, H. E. (2019). Axon-Dependent Patterning and Maintenance of Somatosensory Dendritic Arbors. Developmental Cell, 48(2), 229-244.e4. https://doi.org/10.1016/j.devcel.2018.12.015
Ramirez-Suarez, Nelson J. ; Belalcazar, Helen M. ; Salazar, Christopher J. ; Beyaz, Burcu ; Raja, Benjamin ; Nguyen, Ken C.Q. ; Celestrin, Kevin ; Fredens, Julius ; Færgeman, Nils J. ; Hall, David H. ; Bülow, Hannes E. / Axon-Dependent Patterning and Maintenance of Somatosensory Dendritic Arbors. I: Developmental Cell. 2019 ; Bind 48, Nr. 2. s. 229-244.e4.
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abstract = "The mechanisms that pattern and maintain dendritic arbors are key to understanding the principles that govern nervous system assembly. The activity of presynaptic axons has long been known to shape dendrites, but activity-independent functions of axons in this process have remained elusive. Here, we show that in Caenorhabditis elegans, the axons of the ALA neuron control guidance and extension of the 1° dendrites of PVD somatosensory neurons independently of ALA activity. PVD 1° dendrites mimic ALA axon guidance defects in loss-of-function mutants for the extracellular matrix molecule MIG-6/Papilin or the UNC-6/Netrin pathway, suggesting that axon-dendrite adhesion is important for dendrite formation. We found that the SAX-7/L1CAM cell adhesion molecule engages in distinct molecular mechanisms to mediate extensions of PVD 1° dendrites and maintain the ALA-PVD axon-dendritic fascicle, respectively. Thus, axons can serve as critical scaffolds to pattern and maintain dendrites through contact-dependent but activity-independent mechanisms.",
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Ramirez-Suarez, NJ, Belalcazar, HM, Salazar, CJ, Beyaz, B, Raja, B, Nguyen, KCQ, Celestrin, K, Fredens, J, Færgeman, NJ, Hall, DH & Bülow, HE 2019, 'Axon-Dependent Patterning and Maintenance of Somatosensory Dendritic Arbors', Developmental Cell, bind 48, nr. 2, s. 229-244.e4. https://doi.org/10.1016/j.devcel.2018.12.015

Axon-Dependent Patterning and Maintenance of Somatosensory Dendritic Arbors. / Ramirez-Suarez, Nelson J.; Belalcazar, Helen M.; Salazar, Christopher J.; Beyaz, Burcu; Raja, Benjamin; Nguyen, Ken C.Q.; Celestrin, Kevin; Fredens, Julius; Færgeman, Nils J.; Hall, David H.; Bülow, Hannes E.

I: Developmental Cell, Bind 48, Nr. 2, 28.01.2019, s. 229-244.e4.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Axon-Dependent Patterning and Maintenance of Somatosensory Dendritic Arbors

AU - Ramirez-Suarez, Nelson J.

AU - Belalcazar, Helen M.

AU - Salazar, Christopher J.

AU - Beyaz, Burcu

AU - Raja, Benjamin

AU - Nguyen, Ken C.Q.

AU - Celestrin, Kevin

AU - Fredens, Julius

AU - Færgeman, Nils J.

AU - Hall, David H.

AU - Bülow, Hannes E.

PY - 2019/1/28

Y1 - 2019/1/28

N2 - The mechanisms that pattern and maintain dendritic arbors are key to understanding the principles that govern nervous system assembly. The activity of presynaptic axons has long been known to shape dendrites, but activity-independent functions of axons in this process have remained elusive. Here, we show that in Caenorhabditis elegans, the axons of the ALA neuron control guidance and extension of the 1° dendrites of PVD somatosensory neurons independently of ALA activity. PVD 1° dendrites mimic ALA axon guidance defects in loss-of-function mutants for the extracellular matrix molecule MIG-6/Papilin or the UNC-6/Netrin pathway, suggesting that axon-dendrite adhesion is important for dendrite formation. We found that the SAX-7/L1CAM cell adhesion molecule engages in distinct molecular mechanisms to mediate extensions of PVD 1° dendrites and maintain the ALA-PVD axon-dendritic fascicle, respectively. Thus, axons can serve as critical scaffolds to pattern and maintain dendrites through contact-dependent but activity-independent mechanisms.

AB - The mechanisms that pattern and maintain dendritic arbors are key to understanding the principles that govern nervous system assembly. The activity of presynaptic axons has long been known to shape dendrites, but activity-independent functions of axons in this process have remained elusive. Here, we show that in Caenorhabditis elegans, the axons of the ALA neuron control guidance and extension of the 1° dendrites of PVD somatosensory neurons independently of ALA activity. PVD 1° dendrites mimic ALA axon guidance defects in loss-of-function mutants for the extracellular matrix molecule MIG-6/Papilin or the UNC-6/Netrin pathway, suggesting that axon-dendrite adhesion is important for dendrite formation. We found that the SAX-7/L1CAM cell adhesion molecule engages in distinct molecular mechanisms to mediate extensions of PVD 1° dendrites and maintain the ALA-PVD axon-dendritic fascicle, respectively. Thus, axons can serve as critical scaffolds to pattern and maintain dendrites through contact-dependent but activity-independent mechanisms.

KW - activity-dependent

KW - activity-independent

KW - axon

KW - dendrite

KW - L1CAM

KW - maintenance

KW - Menorin

KW - Netrin

KW - Papilin

KW - self-assembly

U2 - 10.1016/j.devcel.2018.12.015

DO - 10.1016/j.devcel.2018.12.015

M3 - Journal article

VL - 48

SP - 229-244.e4

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 2

ER -

Ramirez-Suarez NJ, Belalcazar HM, Salazar CJ, Beyaz B, Raja B, Nguyen KCQ et al. Axon-Dependent Patterning and Maintenance of Somatosensory Dendritic Arbors. Developmental Cell. 2019 jan 28;48(2):229-244.e4. https://doi.org/10.1016/j.devcel.2018.12.015