Avoiding steroids in pediatric renal transplantation: long-term experience from a single centre

Erik Bo Pedersen, Mohamad El-Faramawi, Nils Foged, Karl Egon Larsen, Bente Jespersen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

 
Udgivelsesdato: 2007-Nov
OriginalsprogEngelsk
TidsskriftPediatric Transplantation
Vol/bind11
Udgave nummer7
Sider (fra-til)730-735
Antal sider5
ISSN1397-3142
DOI
StatusUdgivet - 1. nov. 2007

Fingeraftryk

Kidney Transplantation
Pediatrics
Graft Rejection
Graft Survival

Citer dette

Pedersen, Erik Bo ; El-Faramawi, Mohamad ; Foged, Nils ; Larsen, Karl Egon ; Jespersen, Bente. / Avoiding steroids in pediatric renal transplantation: long-term experience from a single centre. I: Pediatric Transplantation. 2007 ; Bind 11, Nr. 7. s. 730-735.
@article{1079d090cd8711dc8674000ea68e967b,
title = "Avoiding steroids in pediatric renal transplantation: long-term experience from a single centre",
abstract = "We report our experience in pediatric renal transplantation avoiding steroids whenever possible. Immunosuppression consisted of an initial induction with antithymocyte globulin followed by maintenance therapy with a calcineurin inhibitor and MMF. Steroids were only given to selected patients because of the primary disease, recurrence, rejection, or PTLD. Thirty-four transplants grafted into 32 recipients between 1995 and 2005 were followed for a median of 3.5 yr (range 1-9.8). All patients survived. Graft rejection occurred in 10 cases during the first year post-transplantation and graft survival at one, five, and seven yr was 97, 88 and 88{\%}, respectively. Steroids were given to half of the patients (n = 16); in nine cases due to rejection. Only four patients (13{\%}) were continuously on steroids. Calculated GFR at one to five yr post-transplant were 73, 74, 68, 64, and 70 mL/min/1.73 m(2). Unfortunately PTLD occurred in three patients, but all survived with functioning grafts. Accordingly, our findings indicate that steroid avoidance in pediatric renal transplantation is possible with good results with respect to acute graft rejection as well as long-term graft survival.",
author = "Pedersen, {Erik Bo} and Mohamad El-Faramawi and Nils Foged and Larsen, {Karl Egon} and Bente Jespersen",
year = "2007",
month = "11",
day = "1",
doi = "10.1111/j.1399-3046.2007.00731.x",
language = "English",
volume = "11",
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journal = "Pediatric Transplantation",
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Avoiding steroids in pediatric renal transplantation: long-term experience from a single centre. / Pedersen, Erik Bo; El-Faramawi, Mohamad; Foged, Nils; Larsen, Karl Egon; Jespersen, Bente.

I: Pediatric Transplantation, Bind 11, Nr. 7, 01.11.2007, s. 730-735.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Avoiding steroids in pediatric renal transplantation: long-term experience from a single centre

AU - Pedersen, Erik Bo

AU - El-Faramawi, Mohamad

AU - Foged, Nils

AU - Larsen, Karl Egon

AU - Jespersen, Bente

PY - 2007/11/1

Y1 - 2007/11/1

N2 - We report our experience in pediatric renal transplantation avoiding steroids whenever possible. Immunosuppression consisted of an initial induction with antithymocyte globulin followed by maintenance therapy with a calcineurin inhibitor and MMF. Steroids were only given to selected patients because of the primary disease, recurrence, rejection, or PTLD. Thirty-four transplants grafted into 32 recipients between 1995 and 2005 were followed for a median of 3.5 yr (range 1-9.8). All patients survived. Graft rejection occurred in 10 cases during the first year post-transplantation and graft survival at one, five, and seven yr was 97, 88 and 88%, respectively. Steroids were given to half of the patients (n = 16); in nine cases due to rejection. Only four patients (13%) were continuously on steroids. Calculated GFR at one to five yr post-transplant were 73, 74, 68, 64, and 70 mL/min/1.73 m(2). Unfortunately PTLD occurred in three patients, but all survived with functioning grafts. Accordingly, our findings indicate that steroid avoidance in pediatric renal transplantation is possible with good results with respect to acute graft rejection as well as long-term graft survival.

AB - We report our experience in pediatric renal transplantation avoiding steroids whenever possible. Immunosuppression consisted of an initial induction with antithymocyte globulin followed by maintenance therapy with a calcineurin inhibitor and MMF. Steroids were only given to selected patients because of the primary disease, recurrence, rejection, or PTLD. Thirty-four transplants grafted into 32 recipients between 1995 and 2005 were followed for a median of 3.5 yr (range 1-9.8). All patients survived. Graft rejection occurred in 10 cases during the first year post-transplantation and graft survival at one, five, and seven yr was 97, 88 and 88%, respectively. Steroids were given to half of the patients (n = 16); in nine cases due to rejection. Only four patients (13%) were continuously on steroids. Calculated GFR at one to five yr post-transplant were 73, 74, 68, 64, and 70 mL/min/1.73 m(2). Unfortunately PTLD occurred in three patients, but all survived with functioning grafts. Accordingly, our findings indicate that steroid avoidance in pediatric renal transplantation is possible with good results with respect to acute graft rejection as well as long-term graft survival.

U2 - 10.1111/j.1399-3046.2007.00731.x

DO - 10.1111/j.1399-3046.2007.00731.x

M3 - Journal article

C2 - 17910649

VL - 11

SP - 730

EP - 735

JO - Pediatric Transplantation

JF - Pediatric Transplantation

SN - 1397-3142

IS - 7

ER -