Automated, parallel mass spectrometry imaging and structural identification of lipids

Shane R. Ellis, Martin R.L. Paine, Gert B. Eijkel, Josch K. Pauling, Peter Husen, Mark W. Jervelund, Martin Hermansson, Christer S. Ejsing*, Ron M.A. Heeren

*Kontaktforfatter for dette arbejde

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Abstrakt

We report a method that enables automated data-dependent acquisition of lipid tandem mass spectrometry data in parallel with a high-resolution mass spectrometry imaging experiment. The method does not increase the total image acquisition time and is combined with automatic structural assignments. This lipidome-per-pixel approach automatically identified and validated 104 unique molecular lipids and their spatial locations from rat cerebellar tissue.

OriginalsprogEngelsk
TidsskriftNature Methods
Vol/bind15
Udgave nummer7
Sider (fra-til)515-518
ISSN1548-7091
DOI
StatusUdgivet - 2018

Bibliografisk note

Published: 21 May 2018

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