Autoantibodies as diagnostic tools

Gunnar Houen*

*Kontaktforfatter for dette arbejde

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Abstrakt

Autoimmune diseases are very diverse and include many common diseases of unknown etiology. Diagnosis can be challenging but can be facilitated by the identification of characteristic autoantibodies (AuAbs), which are present in varying frequencies. Identification of such AuAbs requires a range of different techniques, depending on the autoantigens in question. Each individual AuAb assay is characterized by analytical sensitivity and specificity, which in turn determines clinical sensitivity and specificity in relation to diseases. Clinical sensitivities and specificities vary much, but many AuAb analyses can be of significant help in establishing correct diagnoses. It remains unsettled whether AuAbs are generally pathogenic, but it is generally agreed that autoimmune diseases are caused by a combination of genetic and environmental factors, and that early and correct diagnosis facilitates treatment.

OriginalsprogEngelsk
TitelAutoantibodies : Methods and Protocols
RedaktørerGunnar Houen
Vol/bind1901
ForlagHumana Press
Publikationsdato1. jan. 2019
Sider1-11
ISBN (Trykt)978-1-4939-8948-5
ISBN (Elektronisk)978-1-4939-8949-2
DOI
StatusUdgivet - 1. jan. 2019
NavnMethods in Molecular Biology
Vol/bind1901
ISSN1064-3745

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Citationsformater

Houen, G. (2019). Autoantibodies as diagnostic tools. I G. Houen (red.), Autoantibodies: Methods and Protocols (Bind 1901, s. 1-11). Humana Press. Methods in Molecular Biology, Bind. 1901 https://doi.org/10.1007/978-1-4939-8949-2_1