Attention and executive functions computer training for attention-deficit/hyperactivity disorder (ADHD): results from a randomized, controlled trial

Aida Bikic, James F Leckman, Torben Ø Christensen, Niels Bilenberg, Søren Dalsgaard

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Resumé

Multicenter randomized clinical superiority single-blind trial investigated the effect of a computer training program targeting multiple cognitive functions. Seventy children with ADHD, aged 6-13, were randomized to intervention or control group. The intervention group used ACTIVATE™ for 8 weeks and both groups received treatment as usual and were assessed in regard to cognitive functions, symptoms, behavioral and functional outcome measures after 8, 12 and 24 weeks. There was no significant effect on the primary outcome, sustained attention (β = - 0.047; CI - 0.247 to 0.153) or the secondary outcomes [parent-rated ADHD-RS, β = - 0.037; CI (- 0.224 to 0.150); teacher-rated-ADHD-RS, β = 0.093; CI (- 0.107 to 0.294); parent-rated-BRIEF, β = - 0.119; CI (- 0.307 to 0.069); and teacher-rated-BRIEF, β = 0.136; CI (- 0.048 to 0.322)]. This multicenter randomized clinical trial found no significant beneficial effects of cognitive training using the computer program ACTIVATE on the primary or secondary outcome measures in children with ADHD. Nevertheless, our study was likely underpowered to detect small to moderate changes.Trial registration ClinicalTrials.gov: NCT01752530, date of registration: December 10, 2012.

OriginalsprogEngelsk
TidsskriftEuropean Child & Adolescent Psychiatry
Vol/bind27
Udgave nummer12
Sider (fra-til)1563-1574
ISSN1018-8827
DOI
StatusUdgivet - dec. 2018

Fingeraftryk

Executive Function
Randomized Controlled Trials
Cognition
Outcome Assessment (Health Care)
Education
Control Groups

Citer dette

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title = "Attention and executive functions computer training for attention-deficit/hyperactivity disorder (ADHD): results from a randomized, controlled trial",
abstract = "Multicenter randomized clinical superiority single-blind trial investigated the effect of a computer training program targeting multiple cognitive functions. Seventy children with ADHD, aged 6-13, were randomized to intervention or control group. The intervention group used ACTIVATE™ for 8 weeks and both groups received treatment as usual and were assessed in regard to cognitive functions, symptoms, behavioral and functional outcome measures after 8, 12 and 24 weeks. There was no significant effect on the primary outcome, sustained attention (β = - 0.047; CI - 0.247 to 0.153) or the secondary outcomes [parent-rated ADHD-RS, β = - 0.037; CI (- 0.224 to 0.150); teacher-rated-ADHD-RS, β = 0.093; CI (- 0.107 to 0.294); parent-rated-BRIEF, β = - 0.119; CI (- 0.307 to 0.069); and teacher-rated-BRIEF, β = 0.136; CI (- 0.048 to 0.322)]. This multicenter randomized clinical trial found no significant beneficial effects of cognitive training using the computer program ACTIVATE on the primary or secondary outcome measures in children with ADHD. Nevertheless, our study was likely underpowered to detect small to moderate changes.Trial registration ClinicalTrials.gov: NCT01752530, date of registration: December 10, 2012.",
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Attention and executive functions computer training for attention-deficit/hyperactivity disorder (ADHD) : results from a randomized, controlled trial. / Bikic, Aida; Leckman, James F; Christensen, Torben Ø; Bilenberg, Niels; Dalsgaard, Søren.

I: European Child & Adolescent Psychiatry, Bind 27, Nr. 12, 12.2018, s. 1563-1574.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Attention and executive functions computer training for attention-deficit/hyperactivity disorder (ADHD)

T2 - results from a randomized, controlled trial

AU - Bikic, Aida

AU - Leckman, James F

AU - Christensen, Torben Ø

AU - Bilenberg, Niels

AU - Dalsgaard, Søren

PY - 2018/12

Y1 - 2018/12

N2 - Multicenter randomized clinical superiority single-blind trial investigated the effect of a computer training program targeting multiple cognitive functions. Seventy children with ADHD, aged 6-13, were randomized to intervention or control group. The intervention group used ACTIVATE™ for 8 weeks and both groups received treatment as usual and were assessed in regard to cognitive functions, symptoms, behavioral and functional outcome measures after 8, 12 and 24 weeks. There was no significant effect on the primary outcome, sustained attention (β = - 0.047; CI - 0.247 to 0.153) or the secondary outcomes [parent-rated ADHD-RS, β = - 0.037; CI (- 0.224 to 0.150); teacher-rated-ADHD-RS, β = 0.093; CI (- 0.107 to 0.294); parent-rated-BRIEF, β = - 0.119; CI (- 0.307 to 0.069); and teacher-rated-BRIEF, β = 0.136; CI (- 0.048 to 0.322)]. This multicenter randomized clinical trial found no significant beneficial effects of cognitive training using the computer program ACTIVATE on the primary or secondary outcome measures in children with ADHD. Nevertheless, our study was likely underpowered to detect small to moderate changes.Trial registration ClinicalTrials.gov: NCT01752530, date of registration: December 10, 2012.

AB - Multicenter randomized clinical superiority single-blind trial investigated the effect of a computer training program targeting multiple cognitive functions. Seventy children with ADHD, aged 6-13, were randomized to intervention or control group. The intervention group used ACTIVATE™ for 8 weeks and both groups received treatment as usual and were assessed in regard to cognitive functions, symptoms, behavioral and functional outcome measures after 8, 12 and 24 weeks. There was no significant effect on the primary outcome, sustained attention (β = - 0.047; CI - 0.247 to 0.153) or the secondary outcomes [parent-rated ADHD-RS, β = - 0.037; CI (- 0.224 to 0.150); teacher-rated-ADHD-RS, β = 0.093; CI (- 0.107 to 0.294); parent-rated-BRIEF, β = - 0.119; CI (- 0.307 to 0.069); and teacher-rated-BRIEF, β = 0.136; CI (- 0.048 to 0.322)]. This multicenter randomized clinical trial found no significant beneficial effects of cognitive training using the computer program ACTIVATE on the primary or secondary outcome measures in children with ADHD. Nevertheless, our study was likely underpowered to detect small to moderate changes.Trial registration ClinicalTrials.gov: NCT01752530, date of registration: December 10, 2012.

KW - ADHD

KW - Cognitive remediation

KW - Cognitive training

KW - Computer training

KW - Executive function training

KW - Non-pharmacological treatment

KW - Single-Blind Method

KW - Parents/psychology

KW - Humans

KW - Male

KW - Treatment Outcome

KW - Therapy, Computer-Assisted/methods

KW - Video Games

KW - Adolescent

KW - Denmark

KW - Female

KW - Executive Function/physiology

KW - Cognition/physiology

KW - Cognitive Behavioral Therapy/methods

KW - Attention/physiology

KW - Child

KW - Attention Deficit Disorder with Hyperactivity/diagnosis

U2 - 10.1007/s00787-018-1151-y

DO - 10.1007/s00787-018-1151-y

M3 - Journal article

C2 - 29644473

VL - 27

SP - 1563

EP - 1574

JO - European Child & Adolescent Psychiatry

JF - European Child & Adolescent Psychiatry

SN - 1018-8827

IS - 12

ER -