Atrial fibrillation pharmacotherapy after hospital discharge between 1995 and 2004: a shift towards beta-blockers.

Morten Lock Hansen, Niels Gadsbøll, Gunnar H Gislason, Steen Z Abildstrom, Tina K Schramm, Fredrik Folke, Jens Friberg, Rikke Sørensen, Søren Rasmussen, Henrik E Poulsen, Lars Køber, Mette Madsen, Christian Torp-Pedersen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2008-Apr
OriginalsprogEngelsk
TidsskriftEuropace
Vol/bind10
Udgave nummer4
Sider (fra-til)395-402
Antal sider7
ISSN1099-5129
DOI
StatusUdgivet - 1. apr. 2008

Fingeraftryk

Amiodarone
Pharmacies
Pharmaceutical Preparations
Logistic Models
Regression Analysis

Citer dette

Hansen, M. L., Gadsbøll, N., Gislason, G. H., Abildstrom, S. Z., Schramm, T. K., Folke, F., ... Torp-Pedersen, C. (2008). Atrial fibrillation pharmacotherapy after hospital discharge between 1995 and 2004: a shift towards beta-blockers. Europace, 10(4), 395-402. https://doi.org/10.1093/europace/eun011
Hansen, Morten Lock ; Gadsbøll, Niels ; Gislason, Gunnar H ; Abildstrom, Steen Z ; Schramm, Tina K ; Folke, Fredrik ; Friberg, Jens ; Sørensen, Rikke ; Rasmussen, Søren ; Poulsen, Henrik E ; Køber, Lars ; Madsen, Mette ; Torp-Pedersen, Christian. / Atrial fibrillation pharmacotherapy after hospital discharge between 1995 and 2004: a shift towards beta-blockers. I: Europace. 2008 ; Bind 10, Nr. 4. s. 395-402.
@article{10ac8050474c11dd9fbe000ea68e967b,
title = "Atrial fibrillation pharmacotherapy after hospital discharge between 1995 and 2004: a shift towards beta-blockers.",
abstract = "AIMS: To study evolvement in pharmacotherapy of atrial fibrillation from 1995 to 2004. METHODS AND RESULTS: All Danish patients were discharged following first-time atrial fibrillation and their pharmacotherapy was identified by individual-level-linkage of nationwide registers of hospitalization and drug dispensing from pharmacies. A total of 108 791 patients survived 30 days after discharge and were included. In 1995-1996, 7.4{\%} of the patients received beta-blockers, increasing to 44.3{\%} in 2003-2004. The corresponding figures for amiodarone were 2.9 and 5.4{\%}. In contrast, use of nondihydropyridine calcium-channel blockers, digoxin, sotalol, and class 1C antiarrhythmics decreased from 20.6, 63.9, 21.3, and 4.0{\%} in 1995-1996 to 12.6, 43.8, 4.2, and 1.3{\%} in 2003-2004, respectively. Notably, patients receiving anticoagulants increased from 29.8 to 43.5{\%}. Multivariate logistic regression analysis revealed females to be associated with more use of digoxin, but less use of amiodarone and oral anticoagulants than males. Patients above 80 years received less pharmacotherapy, apart from digoxin treatment that was more commonly used in elderly. CONCLUSION: Pharmacotherapy of atrial fibrillation has changed towards increased beta-blocker use with a coincident decrease in the use of other rate-limiting drugs and sotalol. Treatment with amiodarone or class 1C antiarrhythmics remained very low. Oral anticoagulant therapy increased considerably, but women and elderly were apparently undertreated.",
keywords = "Adrenergic beta-Antagonists, Adult, Aged, Aged, 80 and over, Amiodarone, Anti-Arrhythmia Agents, Atrial Fibrillation, Calcium Channel Blockers, Denmark, Digoxin, Drug Therapy, Female, Humans, Logistic Models, Longitudinal Studies, Male, Middle Aged, Patient Discharge, Registries, Retrospective Studies, Sotalol",
author = "Hansen, {Morten Lock} and Niels Gadsb{\o}ll and Gislason, {Gunnar H} and Abildstrom, {Steen Z} and Schramm, {Tina K} and Fredrik Folke and Jens Friberg and Rikke S{\o}rensen and S{\o}ren Rasmussen and Poulsen, {Henrik E} and Lars K{\o}ber and Mette Madsen and Christian Torp-Pedersen",
year = "2008",
month = "4",
day = "1",
doi = "10.1093/europace/eun011",
language = "English",
volume = "10",
pages = "395--402",
journal = "Europace",
issn = "1099-5129",
publisher = "Heinemann",
number = "4",

}

Hansen, ML, Gadsbøll, N, Gislason, GH, Abildstrom, SZ, Schramm, TK, Folke, F, Friberg, J, Sørensen, R, Rasmussen, S, Poulsen, HE, Køber, L, Madsen, M & Torp-Pedersen, C 2008, 'Atrial fibrillation pharmacotherapy after hospital discharge between 1995 and 2004: a shift towards beta-blockers.', Europace, bind 10, nr. 4, s. 395-402. https://doi.org/10.1093/europace/eun011

Atrial fibrillation pharmacotherapy after hospital discharge between 1995 and 2004: a shift towards beta-blockers. / Hansen, Morten Lock; Gadsbøll, Niels; Gislason, Gunnar H; Abildstrom, Steen Z; Schramm, Tina K; Folke, Fredrik; Friberg, Jens; Sørensen, Rikke; Rasmussen, Søren; Poulsen, Henrik E; Køber, Lars; Madsen, Mette; Torp-Pedersen, Christian.

I: Europace, Bind 10, Nr. 4, 01.04.2008, s. 395-402.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Atrial fibrillation pharmacotherapy after hospital discharge between 1995 and 2004: a shift towards beta-blockers.

AU - Hansen, Morten Lock

AU - Gadsbøll, Niels

AU - Gislason, Gunnar H

AU - Abildstrom, Steen Z

AU - Schramm, Tina K

AU - Folke, Fredrik

AU - Friberg, Jens

AU - Sørensen, Rikke

AU - Rasmussen, Søren

AU - Poulsen, Henrik E

AU - Køber, Lars

AU - Madsen, Mette

AU - Torp-Pedersen, Christian

PY - 2008/4/1

Y1 - 2008/4/1

N2 - AIMS: To study evolvement in pharmacotherapy of atrial fibrillation from 1995 to 2004. METHODS AND RESULTS: All Danish patients were discharged following first-time atrial fibrillation and their pharmacotherapy was identified by individual-level-linkage of nationwide registers of hospitalization and drug dispensing from pharmacies. A total of 108 791 patients survived 30 days after discharge and were included. In 1995-1996, 7.4% of the patients received beta-blockers, increasing to 44.3% in 2003-2004. The corresponding figures for amiodarone were 2.9 and 5.4%. In contrast, use of nondihydropyridine calcium-channel blockers, digoxin, sotalol, and class 1C antiarrhythmics decreased from 20.6, 63.9, 21.3, and 4.0% in 1995-1996 to 12.6, 43.8, 4.2, and 1.3% in 2003-2004, respectively. Notably, patients receiving anticoagulants increased from 29.8 to 43.5%. Multivariate logistic regression analysis revealed females to be associated with more use of digoxin, but less use of amiodarone and oral anticoagulants than males. Patients above 80 years received less pharmacotherapy, apart from digoxin treatment that was more commonly used in elderly. CONCLUSION: Pharmacotherapy of atrial fibrillation has changed towards increased beta-blocker use with a coincident decrease in the use of other rate-limiting drugs and sotalol. Treatment with amiodarone or class 1C antiarrhythmics remained very low. Oral anticoagulant therapy increased considerably, but women and elderly were apparently undertreated.

AB - AIMS: To study evolvement in pharmacotherapy of atrial fibrillation from 1995 to 2004. METHODS AND RESULTS: All Danish patients were discharged following first-time atrial fibrillation and their pharmacotherapy was identified by individual-level-linkage of nationwide registers of hospitalization and drug dispensing from pharmacies. A total of 108 791 patients survived 30 days after discharge and were included. In 1995-1996, 7.4% of the patients received beta-blockers, increasing to 44.3% in 2003-2004. The corresponding figures for amiodarone were 2.9 and 5.4%. In contrast, use of nondihydropyridine calcium-channel blockers, digoxin, sotalol, and class 1C antiarrhythmics decreased from 20.6, 63.9, 21.3, and 4.0% in 1995-1996 to 12.6, 43.8, 4.2, and 1.3% in 2003-2004, respectively. Notably, patients receiving anticoagulants increased from 29.8 to 43.5%. Multivariate logistic regression analysis revealed females to be associated with more use of digoxin, but less use of amiodarone and oral anticoagulants than males. Patients above 80 years received less pharmacotherapy, apart from digoxin treatment that was more commonly used in elderly. CONCLUSION: Pharmacotherapy of atrial fibrillation has changed towards increased beta-blocker use with a coincident decrease in the use of other rate-limiting drugs and sotalol. Treatment with amiodarone or class 1C antiarrhythmics remained very low. Oral anticoagulant therapy increased considerably, but women and elderly were apparently undertreated.

KW - Adrenergic beta-Antagonists

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Amiodarone

KW - Anti-Arrhythmia Agents

KW - Atrial Fibrillation

KW - Calcium Channel Blockers

KW - Denmark

KW - Digoxin

KW - Drug Therapy

KW - Female

KW - Humans

KW - Logistic Models

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Patient Discharge

KW - Registries

KW - Retrospective Studies

KW - Sotalol

U2 - 10.1093/europace/eun011

DO - 10.1093/europace/eun011

M3 - Journal article

VL - 10

SP - 395

EP - 402

JO - Europace

JF - Europace

SN - 1099-5129

IS - 4

ER -

Hansen ML, Gadsbøll N, Gislason GH, Abildstrom SZ, Schramm TK, Folke F et al. Atrial fibrillation pharmacotherapy after hospital discharge between 1995 and 2004: a shift towards beta-blockers. Europace. 2008 apr 1;10(4):395-402. https://doi.org/10.1093/europace/eun011