Atopic dermatitis: a total genome-scan for susceptibility genes

Annette Haagerup, Torbjørn Bjerke, Peter Oluf Schiøtz, Ronald Dahl, Helle Glud Binderup, Qihua Tan, Torben Arvid Kruse

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Atopic dermatitis is one of the most common chronic diseases of childhood and closely related to other clinical manifestations of allergy. The incidence is high and still increasing. The genetic contribution to disease development is substantial and complex. Only recently genetic research has begun to focus on this phenotype, and specific susceptibility genes remain to be found. To identify candidate regions holding genes for atopic dermatitis we performed a genome-scan in Danish affected sib-pair families containing sib-pairs matching a phenotype definition of both clinical atopic dermatitis and confirmed specific allergy. The scan was undertaken using 446 microsatellite markers and non-parametric linkage results were obtained from the MAPMAKER/SIBS computer program. We found evidence of linkage to three candidate regions in chromosomes 3p (MLS=2.14), 4p (MLS=2.00) and 18q (MLS=2.25), one of which has not been reported previously. Eight additional regions showed weaker but positive results.

OriginalsprogEngelsk
Tidsskrift Acta Dermato-Venereologica
Vol/bind84
Udgave nummer5
Sider (fra-til)346-352
ISSN0001-5555
DOI
StatusUdgivet - 2004

Fingeraftryk

Atopic Dermatitis
Hypersensitivity
Genetic Research
Incidence

Citer dette

Haagerup, Annette ; Bjerke, Torbjørn ; Schiøtz, Peter Oluf ; Dahl, Ronald ; Binderup, Helle Glud ; Tan, Qihua ; Kruse, Torben Arvid. / Atopic dermatitis : a total genome-scan for susceptibility genes. I: Acta Dermato-Venereologica. 2004 ; Bind 84, Nr. 5. s. 346-352.
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Atopic dermatitis : a total genome-scan for susceptibility genes. / Haagerup, Annette; Bjerke, Torbjørn; Schiøtz, Peter Oluf; Dahl, Ronald; Binderup, Helle Glud; Tan, Qihua; Kruse, Torben Arvid.

I: Acta Dermato-Venereologica, Bind 84, Nr. 5, 2004, s. 346-352.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

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T2 - a total genome-scan for susceptibility genes

AU - Haagerup, Annette

AU - Bjerke, Torbjørn

AU - Schiøtz, Peter Oluf

AU - Dahl, Ronald

AU - Binderup, Helle Glud

AU - Tan, Qihua

AU - Kruse, Torben Arvid

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N2 - Atopic dermatitis is one of the most common chronic diseases of childhood and closely related to other clinical manifestations of allergy. The incidence is high and still increasing. The genetic contribution to disease development is substantial and complex. Only recently genetic research has begun to focus on this phenotype, and specific susceptibility genes remain to be found. To identify candidate regions holding genes for atopic dermatitis we performed a genome-scan in Danish affected sib-pair families containing sib-pairs matching a phenotype definition of both clinical atopic dermatitis and confirmed specific allergy. The scan was undertaken using 446 microsatellite markers and non-parametric linkage results were obtained from the MAPMAKER/SIBS computer program. We found evidence of linkage to three candidate regions in chromosomes 3p (MLS=2.14), 4p (MLS=2.00) and 18q (MLS=2.25), one of which has not been reported previously. Eight additional regions showed weaker but positive results.

AB - Atopic dermatitis is one of the most common chronic diseases of childhood and closely related to other clinical manifestations of allergy. The incidence is high and still increasing. The genetic contribution to disease development is substantial and complex. Only recently genetic research has begun to focus on this phenotype, and specific susceptibility genes remain to be found. To identify candidate regions holding genes for atopic dermatitis we performed a genome-scan in Danish affected sib-pair families containing sib-pairs matching a phenotype definition of both clinical atopic dermatitis and confirmed specific allergy. The scan was undertaken using 446 microsatellite markers and non-parametric linkage results were obtained from the MAPMAKER/SIBS computer program. We found evidence of linkage to three candidate regions in chromosomes 3p (MLS=2.14), 4p (MLS=2.00) and 18q (MLS=2.25), one of which has not been reported previously. Eight additional regions showed weaker but positive results.

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KW - Child

KW - Chromosomes

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KW - Dermatitis, Atopic

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KW - Genetic Linkage

KW - Genetic Predisposition to Disease

KW - Genome

KW - Humans

KW - Male

KW - Microsatellite Repeats

KW - Phenotype

KW - Siblings

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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DO - 10.1080/00015550410034426

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JO - Acta Dermatovenereologica

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