Astrocyte-and Microglia-Specific Mitochondrial DNA Deletions Levels in Sporadic Alzheimer's Disease

Sabrina Strobel, Edna Grünblatt, Helmut Heinsen, Peter Riederer, Thomas Espach, Michael Meder, Camelia-Maria Monoranu

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Oxidative stress is implicated in the pathogenesis of neurodegenerative diseases, including sporadic Alzheimer's disease (AD). Mitochondrial DNA (mtDNA) deletions are markers of oxidative damage with an age-dependent accumulation. In a previous study, we analyzed mtDNA levels in diverse neuronal cell types in order to unravel the impact of oxidative stress in brains of AD patients. The aim of this study was to identify possible correlations between mtDNA deletion levels of selected astrocytes and microglia from three brain regions with different vulnerability to AD pathology and different stages of disease compared to controls. Our results reflect a higher vulnerability of hippocampal astrocytes and microglia to oxidative stress compared to other brain regions, such as cerebellum and brain stem.

OriginalsprogEngelsk
TidsskriftJournal of Alzheimer's disease : JAD
Vol/bind67
Udgave nummer1
Sider (fra-til)149-157
ISSN1387-2877
DOI
StatusUdgivet - jan. 2019

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