Associations of Objectively Measured Physical Activity and Abdominal Fat Distribution

A. Philipsen, A. L. S. Hansen, M. E. Jørgensen, S. Brage, B. Carstensen, A. Sandbaek, T. P. Almdal, J. Gram, E. B. Pedersen, T. Lauritzen, D. R. Witte

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Introduction/Purpose: Visceral adipose tissue (VAT) and physical activity are both independent predictors of Type 2 diabetes. Physical activity and overall obesity are inversely associated with each other. Yet the nature of the association between objectively measured dimensions of physical activity and abdominal fat distribution has not been well characterized. We aimed to do so in a middle-age to elderly population at high risk of diabetes. Methods: A cross-sectional analysis of 1134 participants of the ADDITION-PRO study. VAT and subcutaneous adipose tissue (SAT) were assessed one-dimensionally by ultrasonography and physical activity with combined accelerometry and HR monitoring. Linear regression of physical activity energy expenditure (PAEE) and time spent in different physical activity intensity levels on VAT and SAT was performed. Results: Median body mass index (BMI) was 26.6 kg.m(-2) and PAEE was 28.1 kJ.kg(-1).d(-1), with 18.9 h.d(-1) spent sedentary, 4.5 h.d(-1) in light-intensity physical activity, and 0.4 h.d(-1) in moderate-intensity physical activity. PAEE was significantly negatively associated with VAT, and in women, PAEE was also significantly negatively associated with SAT. The difference in VAT was -1.1 mm (95% confidence interval [CI] = -1.8 to -0.3) per 10-kJ.kg(-1).d(-1) increment, and the corresponding difference in SAT for women was -0.6 mm (95% CI = -1.2 to -0.04) in models adjusted for age, sex, and waist circumference. Exchanging 1 h of light physical activity with moderate physical activity was significantly associated with VAT (-4.5 mm, 95% CI = -7.6 to -1.5). Exchanging one sedentary hour with light physical activity was significantly associated with both VAT (-0.9 mm, 95% CI = -0.1 to -1.8) and SAT (-0.4 mm, 95% CI = -0.0 to -0.7). Conclusions: In this population with low physical activity levels, cross-sectional findings indicate that increasing overall physical activity and decreasing time spent sedentary is important to avoid the accumulation of metabolically deleterious VAT.
OriginalsprogEngelsk
TidsskriftMedicine and Science in Sports and Exercise
Vol/bind47
Udgave nummer5
Sider (fra-til)983-989
ISSN0195-9131
DOI
StatusUdgivet - 2015

Bibliografisk note

European Foundation for the Study of Diabetes/Pfizer for Research into Cardiovascular Disease Risk Reduction in Patients with Diabetes [74550801]; Danish Council for Strategic Research; Steno Diabetes Center A/S 2 25207926

Emneord

  • VISCERAL FAT ACCELEROMETRY TYPE 2 DIABETES ULTRASONOGRAPHY ACTIVITY ENERGY-EXPENDITURE HEART-RATE VISCERAL FAT SEDENTARY BEHAVIOR METABOLIC RISK YOUNG MEN ADIPOSITY ADULTS ULTRASONOGRAPHY REPRODUCIBILITY

Citationsformater

Philipsen, A., Hansen, A. L. S., Jørgensen, M. E., Brage, S., Carstensen, B., Sandbaek, A., Almdal, T. P., Gram, J., Pedersen, E. B., Lauritzen, T., & Witte, D. R. (2015). Associations of Objectively Measured Physical Activity and Abdominal Fat Distribution. Medicine and Science in Sports and Exercise, 47(5), 983-989. https://doi.org/10.1249/MSS.0000000000000504