Resumé
In Odense Child Cohort (OCC), concentrations of the pesticide metabolites 3-phenoxybenzoic acid (3-PBA), 3,5,6-trichloro-2-pyridinol (TCPY), 2,4-Dichlorophenoxyacetic acid (2,4-D) and dialkyl phosphates (DAPs) were measured in urine samples collected in gestational week 28 in up to 858 women. Gestational length, birth weight, head and abdominal circumference were obtained from birth records and anogenital distance (AGD) was measured at age three month. We did not find consistent dose-related associations between pesticide metabolite concentrations and birth outcomes or AGD. However, females tended to have shorter abdominal circumference with higher maternal 3-PBA concentrations (β: -0.3 (95% CI: -0.5, -0.003) cm). Further, a non-significant dose-related elongation of AGD in females was seen for 3-PBA (p-trend: 0.14) and diethyl phosphates (p-trend: 0.08). In males, exposure to 2,4-D in the second compared to the first tertile showed a statistically significant shorter AGD (β: -1.55 (-2.81, -0.28) mm). These findings may suggest a weak disturbance of sex-hormone action.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Reproductive toxicology (Elmsford, N.Y.) |
| Vol/bind | 76 |
| Sider (fra-til) | 53-62 |
| ISSN | 0890-6238 |
| DOI | |
| Status | Udgivet - mar. 2018 |
Fingeraftryk
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Associations of maternal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-D with birth outcomes and anogenital distance at 3 months in the Odense Child Cohort. / Dalsager, Louise; Christensen, Lisa Elmer; Kongsholm, Malene Gjelstrup; Kyhl, Henriette Boye; Nielsen, Flemming; Schoeters, Greet; Jensen, Tina Kold; Andersen, Helle Raun.
I: Reproductive toxicology (Elmsford, N.Y.), Bind 76, 03.2018, s. 53-62.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
TY - JOUR
T1 - Associations of maternal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-D with birth outcomes and anogenital distance at 3 months in the Odense Child Cohort
AU - Dalsager, Louise
AU - Christensen, Lisa Elmer
AU - Kongsholm, Malene Gjelstrup
AU - Kyhl, Henriette Boye
AU - Nielsen, Flemming
AU - Schoeters, Greet
AU - Jensen, Tina Kold
AU - Andersen, Helle Raun
N1 - Copyright © 2018 Elsevier Inc. All rights reserved.
PY - 2018/3
Y1 - 2018/3
N2 - In Odense Child Cohort (OCC), concentrations of the pesticide metabolites 3-phenoxybenzoic acid (3-PBA), 3,5,6-trichloro-2-pyridinol (TCPY), 2,4-Dichlorophenoxyacetic acid (2,4-D) and dialkyl phosphates (DAPs) were measured in urine samples collected in gestational week 28 in up to 858 women. Gestational length, birth weight, head and abdominal circumference were obtained from birth records and anogenital distance (AGD) was measured at age three month. We did not find consistent dose-related associations between pesticide metabolite concentrations and birth outcomes or AGD. However, females tended to have shorter abdominal circumference with higher maternal 3-PBA concentrations (β: -0.3 (95% CI: -0.5, -0.003) cm). Further, a non-significant dose-related elongation of AGD in females was seen for 3-PBA (p-trend: 0.14) and diethyl phosphates (p-trend: 0.08). In males, exposure to 2,4-D in the second compared to the first tertile showed a statistically significant shorter AGD (β: -1.55 (-2.81, -0.28) mm). These findings may suggest a weak disturbance of sex-hormone action.
AB - In Odense Child Cohort (OCC), concentrations of the pesticide metabolites 3-phenoxybenzoic acid (3-PBA), 3,5,6-trichloro-2-pyridinol (TCPY), 2,4-Dichlorophenoxyacetic acid (2,4-D) and dialkyl phosphates (DAPs) were measured in urine samples collected in gestational week 28 in up to 858 women. Gestational length, birth weight, head and abdominal circumference were obtained from birth records and anogenital distance (AGD) was measured at age three month. We did not find consistent dose-related associations between pesticide metabolite concentrations and birth outcomes or AGD. However, females tended to have shorter abdominal circumference with higher maternal 3-PBA concentrations (β: -0.3 (95% CI: -0.5, -0.003) cm). Further, a non-significant dose-related elongation of AGD in females was seen for 3-PBA (p-trend: 0.14) and diethyl phosphates (p-trend: 0.08). In males, exposure to 2,4-D in the second compared to the first tertile showed a statistically significant shorter AGD (β: -1.55 (-2.81, -0.28) mm). These findings may suggest a weak disturbance of sex-hormone action.
KW - 2,4-Dichlorophenoxyacetic Acid/toxicity
KW - Anal Canal/anatomy & histology
KW - Anthropometry
KW - Cohort Studies
KW - Female
KW - Genitalia/anatomy & histology
KW - Humans
KW - Infant
KW - Male
KW - Maternal Exposure/adverse effects
KW - Organophosphates/toxicity
KW - Pregnancy
KW - Pregnancy Outcome
KW - Pyrethrins/toxicity
U2 - 10.1016/j.reprotox.2017.12.008
DO - 10.1016/j.reprotox.2017.12.008
M3 - Journal article
VL - 76
SP - 53
EP - 62
JO - Reproductive Toxicology
JF - Reproductive Toxicology
SN - 0890-6238
ER -