Associations of maternal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-D with birth outcomes and anogenital distance at 3 months in the Odense Child Cohort

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Resumé

In Odense Child Cohort (OCC), concentrations of the pesticide metabolites 3-phenoxybenzoic acid (3-PBA), 3,5,6-trichloro-2-pyridinol (TCPY), 2,4-Dichlorophenoxyacetic acid (2,4-D) and dialkyl phosphates (DAPs) were measured in urine samples collected in gestational week 28 in up to 858 women. Gestational length, birth weight, head and abdominal circumference were obtained from birth records and anogenital distance (AGD) was measured at age three month. We did not find consistent dose-related associations between pesticide metabolite concentrations and birth outcomes or AGD. However, females tended to have shorter abdominal circumference with higher maternal 3-PBA concentrations (β: -0.3 (95% CI: -0.5, -0.003) cm). Further, a non-significant dose-related elongation of AGD in females was seen for 3-PBA (p-trend: 0.14) and diethyl phosphates (p-trend: 0.08). In males, exposure to 2,4-D in the second compared to the first tertile showed a statistically significant shorter AGD (β: -1.55 (-2.81, -0.28) mm). These findings may suggest a weak disturbance of sex-hormone action.

OriginalsprogEngelsk
TidsskriftReproductive toxicology (Elmsford, N.Y.)
Vol/bind76
Sider (fra-til)53-62
ISSN0890-6238
DOI
StatusUdgivet - mar. 2018

Fingeraftryk

Maternal Exposure
Pyrethrins
2,4-Dichlorophenoxyacetic Acid
Organophosphates
Herbicides
Insecticides
Metabolites
Pesticides
Gonadal Steroid Hormones
Elongation
Phosphates
Mothers
Urine
3-phenoxybenzoic acid

Citer dette

@article{11c9fb33640a4047abfba513be386f45,
title = "Associations of maternal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-D with birth outcomes and anogenital distance at 3 months in the Odense Child Cohort",
abstract = "In Odense Child Cohort (OCC), concentrations of the pesticide metabolites 3-phenoxybenzoic acid (3-PBA), 3,5,6-trichloro-2-pyridinol (TCPY), 2,4-Dichlorophenoxyacetic acid (2,4-D) and dialkyl phosphates (DAPs) were measured in urine samples collected in gestational week 28 in up to 858 women. Gestational length, birth weight, head and abdominal circumference were obtained from birth records and anogenital distance (AGD) was measured at age three month. We did not find consistent dose-related associations between pesticide metabolite concentrations and birth outcomes or AGD. However, females tended to have shorter abdominal circumference with higher maternal 3-PBA concentrations (β: -0.3 (95{\%} CI: -0.5, -0.003) cm). Further, a non-significant dose-related elongation of AGD in females was seen for 3-PBA (p-trend: 0.14) and diethyl phosphates (p-trend: 0.08). In males, exposure to 2,4-D in the second compared to the first tertile showed a statistically significant shorter AGD (β: -1.55 (-2.81, -0.28) mm). These findings may suggest a weak disturbance of sex-hormone action.",
keywords = "2,4-Dichlorophenoxyacetic Acid/toxicity, Anal Canal/anatomy & histology, Anthropometry, Cohort Studies, Female, Genitalia/anatomy & histology, Humans, Infant, Male, Maternal Exposure/adverse effects, Organophosphates/toxicity, Pregnancy, Pregnancy Outcome, Pyrethrins/toxicity",
author = "Louise Dalsager and Christensen, {Lisa Elmer} and Kongsholm, {Malene Gjelstrup} and Kyhl, {Henriette Boye} and Flemming Nielsen and Greet Schoeters and Jensen, {Tina Kold} and Andersen, {Helle Raun}",
note = "Copyright {\circledC} 2018 Elsevier Inc. All rights reserved.",
year = "2018",
month = "3",
doi = "10.1016/j.reprotox.2017.12.008",
language = "English",
volume = "76",
pages = "53--62",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier",

}

TY - JOUR

T1 - Associations of maternal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-D with birth outcomes and anogenital distance at 3 months in the Odense Child Cohort

AU - Dalsager, Louise

AU - Christensen, Lisa Elmer

AU - Kongsholm, Malene Gjelstrup

AU - Kyhl, Henriette Boye

AU - Nielsen, Flemming

AU - Schoeters, Greet

AU - Jensen, Tina Kold

AU - Andersen, Helle Raun

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2018/3

Y1 - 2018/3

N2 - In Odense Child Cohort (OCC), concentrations of the pesticide metabolites 3-phenoxybenzoic acid (3-PBA), 3,5,6-trichloro-2-pyridinol (TCPY), 2,4-Dichlorophenoxyacetic acid (2,4-D) and dialkyl phosphates (DAPs) were measured in urine samples collected in gestational week 28 in up to 858 women. Gestational length, birth weight, head and abdominal circumference were obtained from birth records and anogenital distance (AGD) was measured at age three month. We did not find consistent dose-related associations between pesticide metabolite concentrations and birth outcomes or AGD. However, females tended to have shorter abdominal circumference with higher maternal 3-PBA concentrations (β: -0.3 (95% CI: -0.5, -0.003) cm). Further, a non-significant dose-related elongation of AGD in females was seen for 3-PBA (p-trend: 0.14) and diethyl phosphates (p-trend: 0.08). In males, exposure to 2,4-D in the second compared to the first tertile showed a statistically significant shorter AGD (β: -1.55 (-2.81, -0.28) mm). These findings may suggest a weak disturbance of sex-hormone action.

AB - In Odense Child Cohort (OCC), concentrations of the pesticide metabolites 3-phenoxybenzoic acid (3-PBA), 3,5,6-trichloro-2-pyridinol (TCPY), 2,4-Dichlorophenoxyacetic acid (2,4-D) and dialkyl phosphates (DAPs) were measured in urine samples collected in gestational week 28 in up to 858 women. Gestational length, birth weight, head and abdominal circumference were obtained from birth records and anogenital distance (AGD) was measured at age three month. We did not find consistent dose-related associations between pesticide metabolite concentrations and birth outcomes or AGD. However, females tended to have shorter abdominal circumference with higher maternal 3-PBA concentrations (β: -0.3 (95% CI: -0.5, -0.003) cm). Further, a non-significant dose-related elongation of AGD in females was seen for 3-PBA (p-trend: 0.14) and diethyl phosphates (p-trend: 0.08). In males, exposure to 2,4-D in the second compared to the first tertile showed a statistically significant shorter AGD (β: -1.55 (-2.81, -0.28) mm). These findings may suggest a weak disturbance of sex-hormone action.

KW - 2,4-Dichlorophenoxyacetic Acid/toxicity

KW - Anal Canal/anatomy & histology

KW - Anthropometry

KW - Cohort Studies

KW - Female

KW - Genitalia/anatomy & histology

KW - Humans

KW - Infant

KW - Male

KW - Maternal Exposure/adverse effects

KW - Organophosphates/toxicity

KW - Pregnancy

KW - Pregnancy Outcome

KW - Pyrethrins/toxicity

U2 - 10.1016/j.reprotox.2017.12.008

DO - 10.1016/j.reprotox.2017.12.008

M3 - Journal article

VL - 76

SP - 53

EP - 62

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

ER -