Associations of exposure to perfluoroalkyl substances with thyroid hormone concentrations and birth size

Christina Xiao, Philippe Grandjean, Damaskini Valvi, Flemming Nielsen, Tina Kold Jensen, Pal Weihe, Youssef Oulhote

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Adequate thyroid function during pregnancy is essential for optimal fetal growth. Gestational exposure to perfluoroalkyl substances (PFASs) can negatively affect birth size and disrupt maternal and neonatal thyroid function, although the interrelationship is unclear.

OBJECTIVE: We aimed to quantify the associations between maternal serum-PFAS concentrations and birth weight, birth length, and cranial circumference. We also aimed to estimate associations between PFAS and thyroid hormone (TH) concentrations, thereby elucidating whether THs potentially mediate the associations between PFAS concentrations and birth size.

METHODS: We studied a population-based prospective cohort of 172 mother-singleton pairs from the Faroe Islands. Twelve PFAS were measured in maternal serum obtained at 34 weeks of gestation. THs were measured in maternal and cord serum. Associations between PFAS concentrations and birth size and TH concentrations were estimated using multivariable linear regressions. Sex-stratified analyses along with a mediation analysis were performed to estimate potential mediating effects of THs in the association between PFAS and birth outcomes.

RESULTS: Several PFASs were negatively associated with birth weight, length, and head circumference, and a general positive association between maternal serum-PFASs and cord serum-thyroid stimulating hormone was found. For instance, a doubling in perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) was associated with a 53% (95% CI: 18%, 99%) and 40% (95% CI: 8%, 81%) increases in thyroid stimulating hormone concentrations, respectively. There was little evidence of sexually dimorphic associations. Overall, THs were not found to mediate associations between PFASs and birth size.

CONCLUSION: In this study, several PFASs were negatively associated with birth size and increased THs, which however did not explain lower birth weight among children exposed to PFAS.

OriginalsprogEngelsk
TidsskriftThe Journal of clinical endocrinology and metabolism
ISSN0021-972X
DOI
StatusE-pub ahead of print - 29. okt. 2019

Fingeraftryk

perfluorooctanoic acid
Thyrotropin
Thyroid Hormones
Mothers
Linear regression
Serum
Denmark
Linear Models
perfluorooctane sulfonic acid
Population

Citer dette

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title = "Associations of exposure to perfluoroalkyl substances with thyroid hormone concentrations and birth size",
abstract = "BACKGROUND: Adequate thyroid function during pregnancy is essential for optimal fetal growth. Gestational exposure to perfluoroalkyl substances (PFASs) can negatively affect birth size and disrupt maternal and neonatal thyroid function, although the interrelationship is unclear.OBJECTIVE: We aimed to quantify the associations between maternal serum-PFAS concentrations and birth weight, birth length, and cranial circumference. We also aimed to estimate associations between PFAS and thyroid hormone (TH) concentrations, thereby elucidating whether THs potentially mediate the associations between PFAS concentrations and birth size.METHODS: We studied a population-based prospective cohort of 172 mother-singleton pairs from the Faroe Islands. Twelve PFAS were measured in maternal serum obtained at 34 weeks of gestation. THs were measured in maternal and cord serum. Associations between PFAS concentrations and birth size and TH concentrations were estimated using multivariable linear regressions. Sex-stratified analyses along with a mediation analysis were performed to estimate potential mediating effects of THs in the association between PFAS and birth outcomes.RESULTS: Several PFASs were negatively associated with birth weight, length, and head circumference, and a general positive association between maternal serum-PFASs and cord serum-thyroid stimulating hormone was found. For instance, a doubling in perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) was associated with a 53{\%} (95{\%} CI: 18{\%}, 99{\%}) and 40{\%} (95{\%} CI: 8{\%}, 81{\%}) increases in thyroid stimulating hormone concentrations, respectively. There was little evidence of sexually dimorphic associations. Overall, THs were not found to mediate associations between PFASs and birth size.CONCLUSION: In this study, several PFASs were negatively associated with birth size and increased THs, which however did not explain lower birth weight among children exposed to PFAS.",
author = "Christina Xiao and Philippe Grandjean and Damaskini Valvi and Flemming Nielsen and Jensen, {Tina Kold} and Pal Weihe and Youssef Oulhote",
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doi = "10.1210/clinem/dgz147",
language = "English",
journal = "Journal of Clinical Endocrinology and Metabolism",
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Associations of exposure to perfluoroalkyl substances with thyroid hormone concentrations and birth size. / Xiao, Christina; Grandjean, Philippe; Valvi, Damaskini; Nielsen, Flemming; Jensen, Tina Kold; Weihe, Pal; Oulhote, Youssef.

I: The Journal of clinical endocrinology and metabolism, 29.10.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Associations of exposure to perfluoroalkyl substances with thyroid hormone concentrations and birth size

AU - Xiao, Christina

AU - Grandjean, Philippe

AU - Valvi, Damaskini

AU - Nielsen, Flemming

AU - Jensen, Tina Kold

AU - Weihe, Pal

AU - Oulhote, Youssef

PY - 2019/10/29

Y1 - 2019/10/29

N2 - BACKGROUND: Adequate thyroid function during pregnancy is essential for optimal fetal growth. Gestational exposure to perfluoroalkyl substances (PFASs) can negatively affect birth size and disrupt maternal and neonatal thyroid function, although the interrelationship is unclear.OBJECTIVE: We aimed to quantify the associations between maternal serum-PFAS concentrations and birth weight, birth length, and cranial circumference. We also aimed to estimate associations between PFAS and thyroid hormone (TH) concentrations, thereby elucidating whether THs potentially mediate the associations between PFAS concentrations and birth size.METHODS: We studied a population-based prospective cohort of 172 mother-singleton pairs from the Faroe Islands. Twelve PFAS were measured in maternal serum obtained at 34 weeks of gestation. THs were measured in maternal and cord serum. Associations between PFAS concentrations and birth size and TH concentrations were estimated using multivariable linear regressions. Sex-stratified analyses along with a mediation analysis were performed to estimate potential mediating effects of THs in the association between PFAS and birth outcomes.RESULTS: Several PFASs were negatively associated with birth weight, length, and head circumference, and a general positive association between maternal serum-PFASs and cord serum-thyroid stimulating hormone was found. For instance, a doubling in perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) was associated with a 53% (95% CI: 18%, 99%) and 40% (95% CI: 8%, 81%) increases in thyroid stimulating hormone concentrations, respectively. There was little evidence of sexually dimorphic associations. Overall, THs were not found to mediate associations between PFASs and birth size.CONCLUSION: In this study, several PFASs were negatively associated with birth size and increased THs, which however did not explain lower birth weight among children exposed to PFAS.

AB - BACKGROUND: Adequate thyroid function during pregnancy is essential for optimal fetal growth. Gestational exposure to perfluoroalkyl substances (PFASs) can negatively affect birth size and disrupt maternal and neonatal thyroid function, although the interrelationship is unclear.OBJECTIVE: We aimed to quantify the associations between maternal serum-PFAS concentrations and birth weight, birth length, and cranial circumference. We also aimed to estimate associations between PFAS and thyroid hormone (TH) concentrations, thereby elucidating whether THs potentially mediate the associations between PFAS concentrations and birth size.METHODS: We studied a population-based prospective cohort of 172 mother-singleton pairs from the Faroe Islands. Twelve PFAS were measured in maternal serum obtained at 34 weeks of gestation. THs were measured in maternal and cord serum. Associations between PFAS concentrations and birth size and TH concentrations were estimated using multivariable linear regressions. Sex-stratified analyses along with a mediation analysis were performed to estimate potential mediating effects of THs in the association between PFAS and birth outcomes.RESULTS: Several PFASs were negatively associated with birth weight, length, and head circumference, and a general positive association between maternal serum-PFASs and cord serum-thyroid stimulating hormone was found. For instance, a doubling in perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) was associated with a 53% (95% CI: 18%, 99%) and 40% (95% CI: 8%, 81%) increases in thyroid stimulating hormone concentrations, respectively. There was little evidence of sexually dimorphic associations. Overall, THs were not found to mediate associations between PFASs and birth size.CONCLUSION: In this study, several PFASs were negatively associated with birth size and increased THs, which however did not explain lower birth weight among children exposed to PFAS.

U2 - 10.1210/clinem/dgz147

DO - 10.1210/clinem/dgz147

M3 - Journal article

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

ER -