Associations of birth size, infancy, and childhood growth with intelligence quotient at 5 years of age: a Danish cohort study

Helene Kirkegaard*, Sören Möller, Chunsen Wu, Jonas Häggström, Sjurdur Frodi Olsen, Jørn Olsen, Ellen Aagaard Nohr

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

BACKGROUND: The correlates of prenatal and postnatal growth on Intelligence Quotient (IQ) in childhood in term-born children living in high-income countries are not well known.

OBJECTIVES: We examined how birth size and growth in infancy and childhood were associated with IQ at age 5 y in term-born children using path analysis.

METHODS: The study sample comprised 1719 children from the Danish National Birth Cohort who participated in a substudy in which psychologists assessed IQ using the Wechsler Primary and Preschool Scales of Intelligence-Revised. Measured weight, length/height, and head circumference at birth, 5 mo, 12 mo, and 5 y were included in a path model to estimate their total, indirect, and direct effects on IQ. All growth measures were included in the model as sex- and age-standardized z-scores.

RESULTS: After adjusting for potential confounders, a positive association between birth weight and IQ was observed, and 88% of the association was direct. Weight gain in infancy was associated with IQ [per z-score increase from 5 to 12 mo, IQ increased by 1.53 (95% CI: 0.14; 2.92) points] whereas weight gain from 12 mo to 5 y was not associated with IQ. Height and head circumference growth in childhood was associated with IQ [per z-score increase from 12 mo to 5 y, IQ increased by 0.98 (95% CI: 0.17; 1.79) and 2.09 (95% CI: 0.78; 3.41) points, respectively].

CONCLUSIONS: In children born at term in an affluent country with free access to health care, higher IQ was seen with greater size at birth and greater weight gain in infancy. Also, greater growth in height and head circumference throughout the first 5 y of life was associated with higher childhood IQ whereas greater weight gain after the first year of life was not.

OriginalsprogEngelsk
TidsskriftThe American Journal of Clinical Nutrition
Vol/bind112
Udgave nummer1
Sider (fra-til)96-105
ISSN0002-9165
DOI
StatusUdgivet - 1. jul. 2020

Bibliografisk note

Copyright © The Author(s) 2020.

Fingeraftryk Dyk ned i forskningsemnerne om 'Associations of birth size, infancy, and childhood growth with intelligence quotient at 5 years of age: a Danish cohort study'. Sammen danner de et unikt fingeraftryk.

  • Citationsformater