Associations between selected allergens, phthalates, nicotine, polycyclic aromatic hydrocarbons, and bedroom ventilation and clinically confirmed asthma, rhinoconjunctivitis, and atopic dermatitis in preschool children

M. Callesen, G. Beko, C. J. Weschler, T. Sigsgaard, Tina Kold Jensen, G. Clausen, J. Toftum, L. A. Norberg, A. Host

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


Previous studies, often using data from questionnaires, have reported associations between various characteristics of indoor environments and allergic disease. The aim of this study has been to investigate possible associations between objectively assessed indoor environmental factors and clinically confirmed asthma, rhinoconjunctivitis, and atopic dermatitis. The study is a cross-sectional case-control study of 500 children aged 3-5years from Odense, Denmark. The 200 cases had at least two parentally reported allergic diseases, while the 300 controls were randomly selected from 2835 participating families. A single physician conducted clinical examinations of all 500 children. Children from the initially random control group with clinically confirmed allergic disease were subsequently excluded from the control group and admitted in the case group, leaving 242 in the healthy control group. For most children, specific IgE's against various allergens were determined. In parallel, dust samples were collected and air change rates were measured in the children's bedrooms. The dust samples were analyzed for phthalate esters, polycyclic aromatic hydrocarbons (PAH), nicotine, and various allergens. Among children diagnosed with asthma, concentrations of nicotine were higher (P
TidsskriftIndoor Air
Udgave nummer2
Sider (fra-til)136-147
StatusUdgivet - 2014

Bibliografisk note

ISI Document Delivery No.: AC8HC Times Cited: 4 Cited Reference Count: 59 Callesen, M. Beko, G. Weschler, C. J. Sigsgaard, T. Jensen, T. K. Clausen, G. Toftum, J. Norberg, L. A. Host, A. Beko, Gabriel/C-8684-2009; Weschler, Charles/A-9788-2009 Weschler, Charles/0000-0002-9097-5850 Villum Foundation; TRYG Fund; Danish Research Council [95-103-21990]; Kirsten and Freddy Johansens Fund [95-103-72087] The study was supported by the Villum Foundation, TRYG Fund, the Danish Research Council (grant 95-103-21990), and the Kirsten and Freddy Johansens Fund (grant 95-103-72087). We thank Carl-Gustaf Bornehag and Jan Sundell for advice and support throughout the study. The authors have no conflict of interests. 4 WILEY-BLACKWELL HOBOKEN INDOOR AIR