Associations between airway hyperresponsiveness, obesity, and lipoproteins in a longitudinal cohort

Finn Rasmussen, Robert Hancox, Parameswaran Nair, Henrik Steen Hansen, Hans Christian Siersted, Mads Nybo

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Abstrakt

Background Epidemiological data have linked obesity with an increased risk of asthma, but the mechanisms responsible for this relationship remain unknown. One possible mechanism, which has received little attention, could be the effect of cholesterol metabolism on airway smooth muscle function. The present study investigated the association between airway hyperresponsiveness (AHR) to methacholine and body mass index (BMI) and plasma lipoproteins [low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total cholesterol]. Methods Associations between AHR, BMI and plasma lipoproteins were assessed in a population-based cohort at ages 14 and 20 years. Results In unadjusted analyses, higher LDL cholesterol levels at age 14 were associated with AHR at age 20 in both sexes (P
OriginalsprogEngelsk
TidsskriftClinical Respiratory Journal
Vol/bind7
Udgave nummer3
Sider (fra-til)268-275
ISSN1752-6981
DOI
StatusUdgivet - 2013

Bibliografisk note

E-pub 12 Oct 2012

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