Association of X chromosome-linked DNA-methylation with mortality in the elderly.

Jesper Lund, Jan Baumbach, Qihua Tan

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

Abstrakt

DNA-methylation (DNAm) can be widely linked to aging using age-associated CpG sites (CpGs). Moreover, studies have shown that DNAm profiles can serve as preditors of all-cause mortality. Epigenome-wide association studies (EWAS) have been frequently performed to look for epigenetic markers of aging and mortality. Earlier it has not been possible to analyze the X-chromosome because of limited sample size because of the fact that females (two) and males (one) have distinct patterns of methylation on the X-chromosome which prevents joint analysis on the two sexes. Now, using the Lothian Birth Cohort datasets (1921, 1936) combined, we here propose an exploratory study for sex-specific X-linked DNAm analysis using the Cox proportional hazard model with time-dependent covariates, with and without L1/L2 penalization, for males (N=668) and females (N=757) separately. Our results show two significant CpGs highly associated with mortality for males with FDR<0.05 (cg02698668, coef -0.74; cg14894216, coef -0.84 and candidate sites for further investigation for the females. Marker cg14894216 is located in the promotor region of CATSPER1, a gene that plays a primary role in the regulation of sperm motility, with the latter having been confirmed to affect male mortality by epidemiological studies. We conclude that X-chromosome could play an important role in the sex-specific epigenetic regulation of all-cause mortality in the elderly population.
OriginalsprogEngelsk
Publikationsdatojun. 2017
StatusUdgivet - jun. 2017
Begivenhed13th Annual Meeting of the International Symposium on Integrative Bioinformatics - University of Southern Denmark, Campusvej 55 5230 Odense, Odense, Danmark
Varighed: 22. jun. 201724. jun. 2017
Konferencens nummer: 13
http://www.imbio.de/ib2017/program.php

Konference

Konference13th Annual Meeting of the International Symposium on Integrative Bioinformatics
Nummer13
LokationUniversity of Southern Denmark, Campusvej 55 5230 Odense
Land/OmrådeDanmark
ByOdense
Periode22/06/201724/06/2017
Internetadresse

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