Association of the blood eosinophil count with hematological malignancies and mortality

Christen L Andersen, Volkert D Siersma, Hans C Hasselbalch, Hanne Vestergaard, Ruben Mesa, Peter Felding, Niels dF Olivarius, Ole W Bjerrum

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Abstrakt

Blood eosinophilia (≥0.5x10(9) /l) may be an early sign of hematological malignancy. We investigated associations between levels of blood eosinophils and risks of hematological malignancies and mortality in order to provide clinically derived cut-offs for referral to specialist hematology care. From the Copenhagen Primary Care Differential Count (CopDiff) Database, we identified 356,196 individuals with at least one differential cell count encompassing the eosinophil count during 2000-2007 and matched these laboratory data with Danish nationwide health registers. We used multivariable logistic regression to calculate odds ratios (ORs) for the 4-year incidences of hematological malignancies and mortality between the eosinophil counts and a reference count of 0.16x10(9) /l which was the median eosinophil count in our data. Risks of hematological malignancies and mortality increased above the median eosinophil count. At the 99th percentile, corresponding to an eosinophil count of 0.75x10(9) /l, risks of hematological malignancies were increased more than two-fold with OR (95% C.I.) of 2.39 (1.91-2.99). Interestingly, risks reached a plateau around an eosinophil count of 1.0x10(9) /l. Risks also increased when the eosinophil count approached zero. Here, counts associated relatively more with acute myeloid leukemia and myelodysplastic syndromes whereas counts above 0.16x10(9) /l associated more with myeloproliferative neoplasms. Eosinophil counts associate with hematological malignancies and mortality even below the definition of eosinophilia. The observed plateau of risks around 1.0x10(9) /l is important for physicians encountering patients with eosinophilia since even mild-to-moderate eosinophilia according to traditional definitions confers maximally increased risks of subsequent/subclinical hematological malignancy. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Hematology
Vol/bind90
Udgave nummer3
Sider (fra-til)225-229
ISSN0361-8609
DOI
StatusUdgivet - 2015

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Citationsformater

Andersen, C. L., Siersma, V. D., Hasselbalch, H. C., Vestergaard, H., Mesa, R., Felding, P., Olivarius, N. DF., & Bjerrum, O. W. (2015). Association of the blood eosinophil count with hematological malignancies and mortality. American Journal of Hematology, 90(3), 225-229. https://doi.org/10.1002/ajh.23916