Association of testicular non-Hodgkin's lymphomas with elevated serum levels of human chorionic gonadotropin-like material

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: null-null
OriginalsprogEngelsk
TidsskriftOncology
Vol/bind53
Udgave nummer2
Sider (fra-til)94-8
Antal sider4
ISSN0030-2414
StatusUdgivet - 1996

Fingeraftryk

Chorionic Gonadotropin
Non-Hodgkin's Lymphoma
Serum
Registries
Germ Cell and Embryonal Neoplasms
Physiologic Monitoring
B-Cell Lymphoma
Lymphoma
Neoplasms
Population

Citer dette

@article{56f3ccd0de6e11dd9909000ea68e967b,
title = "Association of testicular non-Hodgkin's lymphomas with elevated serum levels of human chorionic gonadotropin-like material",
abstract = "Serum beta-human chorionic gonadotropin (s-beta-hCG) is a widely used tumor marker in patients with testicular neoplasia. When elevated in patients with an enlarged testis it is considered as a strong indication of a germ cell tumor. Elevation of S-hCG-like material (S-hCG-1) has been reported in nontesticular non-germ cell tumors including non-Hodgkin's lymphomas (NHL) as well. It has never been investigated whether testicular NHL is also associated with elevated S-hCG-1. In the present study the relationship of testicular NHL with increased S-hCG-1 was investigated. In the Danish population-based NHL registry, LYFO registry, 12 cases with testicular involvement of the lymphoma at the time of diagnosis and that had S-hCG-1 measured prior to treatment were identified, and cases with elevated S-hCG-1 were analyzed clinicopathologically. Of these, 2 patients had elevated levels. Both cases were high-grade, diffuse B-cell NHL in elderly patients. The patients were hemiorchiectomized and after surgery levels of S-hCG-1 declined to normal. The study indicates that S-hCG-1 elevation is quite frequently associated with testicular NHL. The prognostic significance of this elevation remains to be investigated, as does the usefulness of S-hCG-1 as tumor marker for early detection of recurrences and for monitoring the therapy of patients with S-hCG-1 positive NHL.",
keywords = "Aged, Aged, 80 and over, Chorionic Gonadotropin, Humans, Lymphoma, Non-Hodgkin, Male, Testicular Neoplasms, Tumor Markers, Biological",
author = "M{\o}ller, {Michael Boe}",
year = "1996",
language = "English",
volume = "53",
pages = "94--8",
journal = "Oncology",
issn = "0030-2414",
publisher = "S. Karger AG",
number = "2",

}

Association of testicular non-Hodgkin's lymphomas with elevated serum levels of human chorionic gonadotropin-like material. / Møller, Michael Boe.

I: Oncology, Bind 53, Nr. 2, 1996, s. 94-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Association of testicular non-Hodgkin's lymphomas with elevated serum levels of human chorionic gonadotropin-like material

AU - Møller, Michael Boe

PY - 1996

Y1 - 1996

N2 - Serum beta-human chorionic gonadotropin (s-beta-hCG) is a widely used tumor marker in patients with testicular neoplasia. When elevated in patients with an enlarged testis it is considered as a strong indication of a germ cell tumor. Elevation of S-hCG-like material (S-hCG-1) has been reported in nontesticular non-germ cell tumors including non-Hodgkin's lymphomas (NHL) as well. It has never been investigated whether testicular NHL is also associated with elevated S-hCG-1. In the present study the relationship of testicular NHL with increased S-hCG-1 was investigated. In the Danish population-based NHL registry, LYFO registry, 12 cases with testicular involvement of the lymphoma at the time of diagnosis and that had S-hCG-1 measured prior to treatment were identified, and cases with elevated S-hCG-1 were analyzed clinicopathologically. Of these, 2 patients had elevated levels. Both cases were high-grade, diffuse B-cell NHL in elderly patients. The patients were hemiorchiectomized and after surgery levels of S-hCG-1 declined to normal. The study indicates that S-hCG-1 elevation is quite frequently associated with testicular NHL. The prognostic significance of this elevation remains to be investigated, as does the usefulness of S-hCG-1 as tumor marker for early detection of recurrences and for monitoring the therapy of patients with S-hCG-1 positive NHL.

AB - Serum beta-human chorionic gonadotropin (s-beta-hCG) is a widely used tumor marker in patients with testicular neoplasia. When elevated in patients with an enlarged testis it is considered as a strong indication of a germ cell tumor. Elevation of S-hCG-like material (S-hCG-1) has been reported in nontesticular non-germ cell tumors including non-Hodgkin's lymphomas (NHL) as well. It has never been investigated whether testicular NHL is also associated with elevated S-hCG-1. In the present study the relationship of testicular NHL with increased S-hCG-1 was investigated. In the Danish population-based NHL registry, LYFO registry, 12 cases with testicular involvement of the lymphoma at the time of diagnosis and that had S-hCG-1 measured prior to treatment were identified, and cases with elevated S-hCG-1 were analyzed clinicopathologically. Of these, 2 patients had elevated levels. Both cases were high-grade, diffuse B-cell NHL in elderly patients. The patients were hemiorchiectomized and after surgery levels of S-hCG-1 declined to normal. The study indicates that S-hCG-1 elevation is quite frequently associated with testicular NHL. The prognostic significance of this elevation remains to be investigated, as does the usefulness of S-hCG-1 as tumor marker for early detection of recurrences and for monitoring the therapy of patients with S-hCG-1 positive NHL.

KW - Aged

KW - Aged, 80 and over

KW - Chorionic Gonadotropin

KW - Humans

KW - Lymphoma, Non-Hodgkin

KW - Male

KW - Testicular Neoplasms

KW - Tumor Markers, Biological

M3 - Journal article

VL - 53

SP - 94

EP - 98

JO - Oncology

JF - Oncology

SN - 0030-2414

IS - 2

ER -