Association of PTGDR gene polymorphisms with asthma in two Caucasian populations

G. Zhu, J. Vestbo, W. Lenney, M. Silverman, M. Whyte, P. Helms, W. H. Anderson, S. G. Pillai

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The prostanoid DP receptor (PTGDR) is shown to be involved in the asthma patho-physiology and the results from the published genetic association studies are inconsistent. Four single nucleotide polymorphisms (SNPs) in PTGDR were genotyped in 342 and 294 families from UK and Denmark respectively. Asthma and asthma-related phenotypes were analyzed using family-based association analyses. In the UK families, a promoter polymorphism (−731A/G) showed significant associations with asthma (P=0.0022), atopic asthma (P=0.0044), bronchial hyperreactivity or BHR (P=0.00120) and strict asthma (P=0.0008). The P-values for asthma, BHR and strict asthma were significant even after the most stringent correction for the number of markers and the number of phenotypes analyzed (<0.0031). An intronic polymorphism (+6651C/T) also showed significant associations with asthma (P=0.0302), atopic asthma (P=0.0131), BHR (P=0.0249) and strict asthma (P=0.0261). In the Danish families, an intronic polymorphism (+6541C/T) showed significant associations with asthma (P=0.0071), atopic asthma (P=0.0348), BHR (P=0.0033) and strict asthma (P=0.0381). The results of haplotype analyses supported the ones of the single SNP analyses. Thus, we demonstrated significant evidence of association between polymorphisms in PTGDR with asthma phenotypes in the two Caucasian populations.
OriginalsprogEngelsk
TidsskriftGenes and Immunity
Vol/bind8
Sider (fra-til)398-403
Antal sider6
ISSN1466-4879
DOI
StatusUdgivet - jul. 2007
Udgivet eksterntJa

Fingeraftryk

Population
Single Nucleotide Polymorphism
Bronchial Hyperreactivity
Genetic Association Studies
Denmark
Haplotypes

Emneord

  • Adolescent
  • Adult
  • genetics: Asthma
  • Denmark
  • genetics: European Continental Ancestry Group
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Great Britain
  • Haplotypes
  • Humans
  • Male
  • Middle Aged
  • Phenotype
  • Polymorphism, Single Nucleotide
  • genetics: Receptors, Immunologic
  • genetics: Receptors, Prostaglandin

Citer dette

Zhu, G., Vestbo, J., Lenney, W., Silverman, M., Whyte, M., Helms, P., ... Pillai, S. G. (2007). Association of PTGDR gene polymorphisms with asthma in two Caucasian populations. Genes and Immunity, 8, 398-403. https://doi.org/10.1038/sj.gene.6364399
Zhu, G. ; Vestbo, J. ; Lenney, W. ; Silverman, M. ; Whyte, M. ; Helms, P. ; Anderson, W. H. ; Pillai, S. G. / Association of PTGDR gene polymorphisms with asthma in two Caucasian populations. I: Genes and Immunity. 2007 ; Bind 8. s. 398-403.
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abstract = "The prostanoid DP receptor (PTGDR) is shown to be involved in the asthma patho-physiology and the results from the published genetic association studies are inconsistent. Four single nucleotide polymorphisms (SNPs) in PTGDR were genotyped in 342 and 294 families from UK and Denmark respectively. Asthma and asthma-related phenotypes were analyzed using family-based association analyses. In the UK families, a promoter polymorphism (−731A/G) showed significant associations with asthma (P=0.0022), atopic asthma (P=0.0044), bronchial hyperreactivity or BHR (P=0.00120) and strict asthma (P=0.0008). The P-values for asthma, BHR and strict asthma were significant even after the most stringent correction for the number of markers and the number of phenotypes analyzed (<0.0031). An intronic polymorphism (+6651C/T) also showed significant associations with asthma (P=0.0302), atopic asthma (P=0.0131), BHR (P=0.0249) and strict asthma (P=0.0261). In the Danish families, an intronic polymorphism (+6541C/T) showed significant associations with asthma (P=0.0071), atopic asthma (P=0.0348), BHR (P=0.0033) and strict asthma (P=0.0381). The results of haplotype analyses supported the ones of the single SNP analyses. Thus, we demonstrated significant evidence of association between polymorphisms in PTGDR with asthma phenotypes in the two Caucasian populations.",
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Zhu, G, Vestbo, J, Lenney, W, Silverman, M, Whyte, M, Helms, P, Anderson, WH & Pillai, SG 2007, 'Association of PTGDR gene polymorphisms with asthma in two Caucasian populations', Genes and Immunity, bind 8, s. 398-403. https://doi.org/10.1038/sj.gene.6364399

Association of PTGDR gene polymorphisms with asthma in two Caucasian populations. / Zhu, G.; Vestbo, J.; Lenney, W.; Silverman, M.; Whyte, M.; Helms, P.; Anderson, W. H.; Pillai, S. G.

I: Genes and Immunity, Bind 8, 07.2007, s. 398-403.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Association of PTGDR gene polymorphisms with asthma in two Caucasian populations

AU - Zhu, G.

AU - Vestbo, J.

AU - Lenney, W.

AU - Silverman, M.

AU - Whyte, M.

AU - Helms, P.

AU - Anderson, W. H.

AU - Pillai, S. G.

PY - 2007/7

Y1 - 2007/7

N2 - The prostanoid DP receptor (PTGDR) is shown to be involved in the asthma patho-physiology and the results from the published genetic association studies are inconsistent. Four single nucleotide polymorphisms (SNPs) in PTGDR were genotyped in 342 and 294 families from UK and Denmark respectively. Asthma and asthma-related phenotypes were analyzed using family-based association analyses. In the UK families, a promoter polymorphism (−731A/G) showed significant associations with asthma (P=0.0022), atopic asthma (P=0.0044), bronchial hyperreactivity or BHR (P=0.00120) and strict asthma (P=0.0008). The P-values for asthma, BHR and strict asthma were significant even after the most stringent correction for the number of markers and the number of phenotypes analyzed (<0.0031). An intronic polymorphism (+6651C/T) also showed significant associations with asthma (P=0.0302), atopic asthma (P=0.0131), BHR (P=0.0249) and strict asthma (P=0.0261). In the Danish families, an intronic polymorphism (+6541C/T) showed significant associations with asthma (P=0.0071), atopic asthma (P=0.0348), BHR (P=0.0033) and strict asthma (P=0.0381). The results of haplotype analyses supported the ones of the single SNP analyses. Thus, we demonstrated significant evidence of association between polymorphisms in PTGDR with asthma phenotypes in the two Caucasian populations.

AB - The prostanoid DP receptor (PTGDR) is shown to be involved in the asthma patho-physiology and the results from the published genetic association studies are inconsistent. Four single nucleotide polymorphisms (SNPs) in PTGDR were genotyped in 342 and 294 families from UK and Denmark respectively. Asthma and asthma-related phenotypes were analyzed using family-based association analyses. In the UK families, a promoter polymorphism (−731A/G) showed significant associations with asthma (P=0.0022), atopic asthma (P=0.0044), bronchial hyperreactivity or BHR (P=0.00120) and strict asthma (P=0.0008). The P-values for asthma, BHR and strict asthma were significant even after the most stringent correction for the number of markers and the number of phenotypes analyzed (<0.0031). An intronic polymorphism (+6651C/T) also showed significant associations with asthma (P=0.0302), atopic asthma (P=0.0131), BHR (P=0.0249) and strict asthma (P=0.0261). In the Danish families, an intronic polymorphism (+6541C/T) showed significant associations with asthma (P=0.0071), atopic asthma (P=0.0348), BHR (P=0.0033) and strict asthma (P=0.0381). The results of haplotype analyses supported the ones of the single SNP analyses. Thus, we demonstrated significant evidence of association between polymorphisms in PTGDR with asthma phenotypes in the two Caucasian populations.

KW - Adolescent

KW - Adult

KW - genetics: Asthma

KW - Denmark

KW - genetics: European Continental Ancestry Group

KW - Female

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Great Britain

KW - Haplotypes

KW - Humans

KW - Male

KW - Middle Aged

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - genetics: Receptors, Immunologic

KW - genetics: Receptors, Prostaglandin

U2 - 10.1038/sj.gene.6364399

DO - 10.1038/sj.gene.6364399

M3 - Journal article

VL - 8

SP - 398

EP - 403

JO - Genes and Immunity

JF - Genes and Immunity

SN - 1466-4879

ER -