Association of PHB 1630 C&gt;T and MTHFR 677 C&gt;T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study

A Jakubowska; D Rozkrut; A Antoniou; U Hamann; R J Scott; L McGuffog; S Healy; O M Sinilnikova; G Rennert; F Lejbkowicz; A Flugelman; I L Andrulis; G Glendon; H Ozcelik; M Thomassen; M Paligo; P Aretini; J Kantala; B Aroer; A von Wachenfeldt; A Liljegren; N Loman; K Herbst; U Kristoffersson; R Rosenquist; P Karlsson; M Stenmark-Askmalm; B Melin; K L Nathanson; S M Domchek; T Byrski; T Huzarski; J Gronwald; J Menkiszak; C Cybulski; P Serrano; A Osorio; T R Cajal; M Tsitlaidou; J Benítez; M Gilbert; M Rookus; C M Aalfs; I Kluijt; J L Boessenkool-Pape; H E J Meijers-Heijboer; J C Oosterwijk; C J van Asperen; M J Blok; M R Nelen; OCGN

doi:10.1038/bjc.2012.160

Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study

A Jakubowska
, D Rozkrut
, A Antoniou
, U Hamann
, R J Scott
, L McGuffog
, S Healy
, O M Sinilnikova
, G Rennert
, F Lejbkowicz
, A Flugelman
, I L Andrulis
, G Glendon
, H Ozcelik
, M Thomassen
, M Paligo
, P Aretini
, J Kantala
, B Aroer
, A von Wachenfeldt

A Liljegren, N Loman, K Herbst, U Kristoffersson, R Rosenquist, P Karlsson, M Stenmark-Askmalm, B Melin, K L Nathanson, S M Domchek, T Byrski, T Huzarski, J Gronwald, J Menkiszak, C Cybulski, P Serrano, A Osorio, T R Cajal, M Tsitlaidou, J Benítez, M Gilbert, M Rookus, C M Aalfs, I Kluijt, J L Boessenkool-Pape, H E J Meijers-Heijboer, J C Oosterwijk, C J van Asperen, M J Blok, M R Nelen, OCGN

KI, OUH, Forskningsenhed for Klinisk Genetik (Odense)

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methylene-tetrahydrofolate reductase (MTHFR), both of which are important either directly or indirectly in maintaining genomic integrity.

Originalsprog	Engelsk
Tidsskrift	British Journal of Cancer
Vol/bind	106
Udgave nummer	12
Sider (fra-til)	2016-24
Antal sider	9
ISSN	0007-0920
DOI	https://doi.org/10.1038/bjc.2012.160
Status	Udgivet - 2012

Dokumenter og links

10.1038/bjc.2012.160

SDU link

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Citationsformater

Jakubowska, A., Rozkrut, D., Antoniou, A., Hamann, U., Scott, R. J., McGuffog, L., Healy, S., Sinilnikova, O. M., Rennert, G., Lejbkowicz, F., Flugelman, A., Andrulis, I. L., Glendon, G., Ozcelik, H., Thomassen, M., Paligo, M., Aretini, P., Kantala, J., Aroer, B., ... OCGN (2012). Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study. British Journal of Cancer, 106(12), 2016-24. https://doi.org/10.1038/bjc.2012.160

@article{63d1594b86c149fe8268035277376243,

title = "Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study",

abstract = "The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methylene-tetrahydrofolate reductase (MTHFR), both of which are important either directly or indirectly in maintaining genomic integrity.",

keywords = "Breast Neoplasms, Female, Genes, BRCA1, Genes, BRCA2, Genetic Predisposition to Disease, Heterozygote, Humans, Methylenetetrahydrofolate Reductase (NADPH2), Mutation, Ovarian Neoplasms, Polymorphism, Genetic, Repressor Proteins, Risk",

author = "A Jakubowska and D Rozkrut and A Antoniou and U Hamann and Scott, \{R J\} and L McGuffog and S Healy and Sinilnikova, \{O M\} and G Rennert and F Lejbkowicz and A Flugelman and Andrulis, \{I L\} and G Glendon and H Ozcelik and M Thomassen and M Paligo and P Aretini and J Kantala and B Aroer and \{von Wachenfeldt\}, A and A Liljegren and N Loman and K Herbst and U Kristoffersson and R Rosenquist and P Karlsson and M Stenmark-Askmalm and B Melin and Nathanson, \{K L\} and Domchek, \{S M\} and T Byrski and T Huzarski and J Gronwald and J Menkiszak and C Cybulski and P Serrano and A Osorio and Cajal, \{T R\} and M Tsitlaidou and J Ben{\'i}tez and M Gilbert and M Rookus and Aalfs, \{C M\} and I Kluijt and Boessenkool-Pape, \{J L\} and Meijers-Heijboer, \{H E J\} and Oosterwijk, \{J C\} and \{van Asperen\}, \{C J\} and Blok, \{M J\} and Nelen, \{M R\} and OCGN",

year = "2012",

doi = "10.1038/bjc.2012.160",

language = "English",

volume = "106",

pages = "2016--24",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Springer",

number = "12",

}

Jakubowska, A, Rozkrut, D, Antoniou, A, Hamann, U, Scott, RJ, McGuffog, L, Healy, S, Sinilnikova, OM, Rennert, G, Lejbkowicz, F, Flugelman, A, Andrulis, IL, Glendon, G, Ozcelik, H, Thomassen, M, Paligo, M, Aretini, P, Kantala, J, Aroer, B, von Wachenfeldt, A, Liljegren, A, Loman, N, Herbst, K, Kristoffersson, U, Rosenquist, R, Karlsson, P, Stenmark-Askmalm, M, Melin, B, Nathanson, KL, Domchek, SM, Byrski, T, Huzarski, T, Gronwald, J, Menkiszak, J, Cybulski, C, Serrano, P, Osorio, A, Cajal, TR, Tsitlaidou, M, Benítez, J, Gilbert, M, Rookus, M, Aalfs, CM, Kluijt, I, Boessenkool-Pape, JL, Meijers-Heijboer, HEJ, Oosterwijk, JC, van Asperen, CJ, Blok, MJ, Nelen, MR & OCGN 2012, 'Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study', British Journal of Cancer, bind 106, nr. 12, s. 2016-24. https://doi.org/10.1038/bjc.2012.160

TY - JOUR

T1 - Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers

T2 - results from a multicenter study

AU - Jakubowska, A

AU - Rozkrut, D

AU - Antoniou, A

AU - Hamann, U

AU - Scott, R J

AU - McGuffog, L

AU - Healy, S

AU - Sinilnikova, O M

AU - Rennert, G

AU - Lejbkowicz, F

AU - Flugelman, A

AU - Andrulis, I L

AU - Glendon, G

AU - Ozcelik, H

AU - Thomassen, M

AU - Paligo, M

AU - Aretini, P

AU - Kantala, J

AU - Aroer, B

AU - von Wachenfeldt, A

AU - Liljegren, A

AU - Loman, N

AU - Herbst, K

AU - Kristoffersson, U

AU - Rosenquist, R

AU - Karlsson, P

AU - Stenmark-Askmalm, M

AU - Melin, B

AU - Nathanson, K L

AU - Domchek, S M

AU - Byrski, T

AU - Huzarski, T

AU - Gronwald, J

AU - Menkiszak, J

AU - Cybulski, C

AU - Serrano, P

AU - Osorio, A

AU - Cajal, T R

AU - Tsitlaidou, M

AU - Benítez, J

AU - Gilbert, M

AU - Rookus, M

AU - Aalfs, C M

AU - Kluijt, I

AU - Boessenkool-Pape, J L

AU - Meijers-Heijboer, H E J

AU - Oosterwijk, J C

AU - van Asperen, C J

AU - Blok, M J

AU - Nelen, M R

AU - OCGN

PY - 2012

Y1 - 2012

N2 - The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methylene-tetrahydrofolate reductase (MTHFR), both of which are important either directly or indirectly in maintaining genomic integrity.

AB - The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methylene-tetrahydrofolate reductase (MTHFR), both of which are important either directly or indirectly in maintaining genomic integrity.

KW - Breast Neoplasms

KW - Female

KW - Genes, BRCA1

KW - Genes, BRCA2

KW - Genetic Predisposition to Disease

KW - Heterozygote

KW - Humans

KW - Methylenetetrahydrofolate Reductase (NADPH2)

KW - Mutation

KW - Ovarian Neoplasms

KW - Polymorphism, Genetic

KW - Repressor Proteins

KW - Risk

U2 - 10.1038/bjc.2012.160

DO - 10.1038/bjc.2012.160

M3 - Journal article

C2 - 22669161

SN - 0007-0920

VL - 106

SP - 2016

EP - 2024

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 12