Association of periconceptional multivitamin use with reduced risk of preeclampsia among normal-weight women in the Danish National Birth Cohort

Janet M Catov, Ellen Aagaard Nøhr, Lisa M Bodnar, Vibeke K Knudson, Sjurdur F. Olsen, Jørn Olsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2009-Jun-1
OriginalsprogEngelsk
TidsskriftAmerican Journal of Epidemiology
Vol/bind169
Udgave nummer11
Sider (fra-til)1304-11
Antal sider7
ISSN0002-9262
DOI
StatusUdgivet - 2009
Udgivet eksterntJa

Fingeraftryk

Pre-Eclampsia
Weights and Measures
Body Mass Index
Confidence Intervals
International Classification of Diseases

Citer dette

Catov, Janet M ; Nøhr, Ellen Aagaard ; Bodnar, Lisa M ; Knudson, Vibeke K ; Olsen, Sjurdur F. ; Olsen, Jørn. / Association of periconceptional multivitamin use with reduced risk of preeclampsia among normal-weight women in the Danish National Birth Cohort. I: American Journal of Epidemiology. 2009 ; Bind 169, Nr. 11. s. 1304-11.
@article{efad2329da494e2291947855bddc86e4,
title = "Association of periconceptional multivitamin use with reduced risk of preeclampsia among normal-weight women in the Danish National Birth Cohort",
abstract = "The timing and frequency of periconceptional multivitamin use may be related to the risk of preeclampsia. Women in the Danish National Birth Cohort (1997-2003) reported multivitamin or folate-only supplement use during a 12-week periconceptional period (from 4 weeks prior to 8 weeks after the last menstrual period). Preeclampsia cases were identified by using International Classification of Diseases, Tenth Revision, codes. Cox regression was used to estimate the association of frequency (weeks of use) and timing (preconception and postconception) of use with preeclampsia risk. Overall, there were 668 cases of preeclampsia (2.3{\%}), and 18,551 women (65{\%}) reported periconceptional multivitamin use. After adjustment, regular use (12 of 12 weeks) was related to a reduced risk of preeclampsia among normal-weight women. Compared with nonusers with a body mass index of 22 kg/m(2), regular multivitamin users with the same body mass index had a 20{\%} reduced risk of preeclampisa (hazard ratio = 0.78, 95{\%} confidence interval: 0.60, 0.99). In addition, regular use in the postconception period only was associated with reduced risk, a relation that also appeared to be limited to women with a body mass index of <25 kg/m(2) (hazard ratio = 0.63, 95{\%} confidence interval: 0.42, 0.93). Folate-only supplement use was unrelated to preeclampsia risk. Regular periconceptional multivitamin use was associated with a reduced risk of preeclampsia among normal-weight women, and the immediate postconception period appeared to be the relevant exposure window.",
author = "Catov, {Janet M} and N{\o}hr, {Ellen Aagaard} and Bodnar, {Lisa M} and Knudson, {Vibeke K} and Olsen, {Sjurdur F.} and J{\o}rn Olsen",
year = "2009",
doi = "10.1093/aje/kwp052",
language = "English",
volume = "169",
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journal = "American Journal of Epidemiology",
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Association of periconceptional multivitamin use with reduced risk of preeclampsia among normal-weight women in the Danish National Birth Cohort. / Catov, Janet M; Nøhr, Ellen Aagaard; Bodnar, Lisa M; Knudson, Vibeke K; Olsen, Sjurdur F.; Olsen, Jørn.

I: American Journal of Epidemiology, Bind 169, Nr. 11, 2009, s. 1304-11.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Association of periconceptional multivitamin use with reduced risk of preeclampsia among normal-weight women in the Danish National Birth Cohort

AU - Catov, Janet M

AU - Nøhr, Ellen Aagaard

AU - Bodnar, Lisa M

AU - Knudson, Vibeke K

AU - Olsen, Sjurdur F.

AU - Olsen, Jørn

PY - 2009

Y1 - 2009

N2 - The timing and frequency of periconceptional multivitamin use may be related to the risk of preeclampsia. Women in the Danish National Birth Cohort (1997-2003) reported multivitamin or folate-only supplement use during a 12-week periconceptional period (from 4 weeks prior to 8 weeks after the last menstrual period). Preeclampsia cases were identified by using International Classification of Diseases, Tenth Revision, codes. Cox regression was used to estimate the association of frequency (weeks of use) and timing (preconception and postconception) of use with preeclampsia risk. Overall, there were 668 cases of preeclampsia (2.3%), and 18,551 women (65%) reported periconceptional multivitamin use. After adjustment, regular use (12 of 12 weeks) was related to a reduced risk of preeclampsia among normal-weight women. Compared with nonusers with a body mass index of 22 kg/m(2), regular multivitamin users with the same body mass index had a 20% reduced risk of preeclampisa (hazard ratio = 0.78, 95% confidence interval: 0.60, 0.99). In addition, regular use in the postconception period only was associated with reduced risk, a relation that also appeared to be limited to women with a body mass index of <25 kg/m(2) (hazard ratio = 0.63, 95% confidence interval: 0.42, 0.93). Folate-only supplement use was unrelated to preeclampsia risk. Regular periconceptional multivitamin use was associated with a reduced risk of preeclampsia among normal-weight women, and the immediate postconception period appeared to be the relevant exposure window.

AB - The timing and frequency of periconceptional multivitamin use may be related to the risk of preeclampsia. Women in the Danish National Birth Cohort (1997-2003) reported multivitamin or folate-only supplement use during a 12-week periconceptional period (from 4 weeks prior to 8 weeks after the last menstrual period). Preeclampsia cases were identified by using International Classification of Diseases, Tenth Revision, codes. Cox regression was used to estimate the association of frequency (weeks of use) and timing (preconception and postconception) of use with preeclampsia risk. Overall, there were 668 cases of preeclampsia (2.3%), and 18,551 women (65%) reported periconceptional multivitamin use. After adjustment, regular use (12 of 12 weeks) was related to a reduced risk of preeclampsia among normal-weight women. Compared with nonusers with a body mass index of 22 kg/m(2), regular multivitamin users with the same body mass index had a 20% reduced risk of preeclampisa (hazard ratio = 0.78, 95% confidence interval: 0.60, 0.99). In addition, regular use in the postconception period only was associated with reduced risk, a relation that also appeared to be limited to women with a body mass index of <25 kg/m(2) (hazard ratio = 0.63, 95% confidence interval: 0.42, 0.93). Folate-only supplement use was unrelated to preeclampsia risk. Regular periconceptional multivitamin use was associated with a reduced risk of preeclampsia among normal-weight women, and the immediate postconception period appeared to be the relevant exposure window.

U2 - 10.1093/aje/kwp052

DO - 10.1093/aje/kwp052

M3 - Journal article

C2 - 19372217

VL - 169

SP - 1304

EP - 1311

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 11

ER -